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Biomedical subjects

A Rebel

Publications and source records attributed to A Rebel.

At least 73 records · Page 4Linked to original sources
PubMed1975

[Osteoclastic inclusions in Paget's disease of bone].

An electron microscope study of 35 bone biopsies from patients with Paget's disease confirmed the constnat presence of intra-nuclear and intracytoplasmic inclusions, which seemed to be the most specific anomalies of the osteoclasts. The presence of these inclusions leads to their comparison with other inclusions described in certain affections for which the viral etiology is at present under discussion.

Biopsy↗
PubMed1975

[Test for hypocalcemia due to calcitonin in the normal subject and in patients with osteoporosis or Paget's disease. Preliminary results].

The authors report the variations in calcaemia and in circulating immunoreactive PTH produced by the intramuscular injection of 5 units of porcine calcitonin in normal subjects and in patients suffering from osteoporosis or Paget's disease. After having determined the levels of 25-hydroxy-vitamin D circulating in the different groups, the authors note that comparison of these variations makes it possible to regroup the different types of reaction following the injection of the hypocalcaemic hormone. In patients suffering from pure osteoporosis, hypocalcaemia was slow to appear, was of moderate intensity, but was prolonged. The osteoporo-malacia patients did not produce a specific reaction and certain of them appeared "insensitive" to calcitonin. Results obtained in patients with Paget's disease confirm the hypocalaemic action of calcitonin even at a low dosage. With this test, the authors hope to contribute to studies of demineralizing affections and to overcoming them.

Adult↗
PubMedDate not supplied

[Current aspects of Paget's bone disease].

The clinical and laboratory signs, as well as the imaging and course of Paget's disease of bone, are now well known. This chronic and usually benign disease is characterized by excessive remodelling of bone tissue, associated with an increase, sometimes considerable, of osteoclast resorption and osteoblast formation activities. Studies conducted during the last two decades were aimed at determining more precisely some aspects of the disease, notably: its epidemiological aspect and in particular its geographical distribution; its aetiological aspect using data obtained from electron microscopy, immunocytology and hydridization in situ, which has led to the hypothesis of a viral origin, and finally its therapeutic aspect with the recent introduction of truly effective treatments such as calcitonin and biphosphonates.

Bone and Bones↗
PubMedDate not supplied

Transposed ciliary microtubules in Kartagener's syndrome. A case report with electron microscopy of bronchial and nasal brushings.

Report is made of the case of a 44-year-old white woman with Kartagener's syndrome marked by respiratory disorders and repeated serous otitis since infancy. The technique of cell sampling through bronchial and nasal brushings facilitated observation of ciliary structures in electron microscopy. The results revealed a specific anomaly in the organization of the ciliary microtubules. The doublet transposition observed may be associated with ciliary dyskinesia.

Adult↗