[Small cell tumors in children: contribution to the solution of the problem of differential diagnosis with immunohistochemistry and electron microscopy].
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Biomedical subjects
Publications and source records attributed to A Reale.
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Whereas the numbers of nerve cells in several areas of the cerebral cortex are reported to decrease with aging, the fate of the neurons of the subcortical nuclei is controversial. This work is concerned with a morphometric study of the nerve cell population of the putamen through cell counting in 24 subjects aged 62 to 90 years. Our data suggest that there is no significant decline in the small-cell density with aging, nor any differences according to sex. No conclusions on the functions of the aging brain should be inferred from cell counting alone, since other signs of functional damage, such as impairment of the synapses or decrease in their number probably precede cell loss.
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A significant (p less than 0.01) difference in the mitotic index between 31 benign and 4 malignant schwannomas is reported. An increased mitotic activity has been related to malignancy in previous works, although no statistical studies have been carried out on its diagnostic value. Our results suggest that the mitotic index should be considered an effective, convenient feature of distinction in doubtful instances, especially as no other trait of malignancy can be similarly measured.
Our experience, as well as the latest literature in the field, stresses the importance of the clinical and neurological examinations in cases of minor head injury. This could avoid the performance of unnecessary imaging and EEG studies and the admittance of children who only need pharmacological therapy in order to relieve the neurotoxic effects of trauma at the axonal and cellular levels.