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Biomedical subjects

A Rausing

Publications and source records attributed to A Rausing.

At least 19 recordsLinked to original sources
PubMed1992

Basal cell carcinoma. An epidemiologic study in a defined population.

BACKGROUND: The incidence of basal cell carcinoma (BCC) in a defined population is unknown. METHODS: The incidence of histologically diagnosed cases of BCC in a defined population of a city in southern Sweden was studied. Four 2-year periods were examined from 1970 to 1986. Cases from 1970 and 1980 were reexamined microscopically. RESULTS: From 1970 to 1986, the age-standardized incidence of BCC was doubled. BCC was equally common in male and female patients. It was possible to trace another BCC in the medical history of 41% of the patients. The risk of development of BCC increased rapidly with age greater than 55 years. Approximately two-thirds of the tumors were found in the head and neck region. There was a possible increase in superficial multicentric tumors on the trunk but otherwise an essentially unchanged pattern in type and distribution. CONCLUSIONS: The age-standardized incidence of histologically diagnosed BCC was doubled from 1970 to 1986. The rapid increase should be taken into consideration when planning allocation of medical resources.

Adult↗
PubMed1989

Staphylococcal wound infection in the pig: Part I. Course.

Full-thickness excision wounds infected with Staphylococcus hyicus, a pig pathogen, or Staphylococcus aureus, a human pathogen, were produced in pigs. The inoculated wounds were kept occluded for 2 days and then exposed and biopsied at intervals for 9 to 12 days. The exposed lesions were edematous and exudative. The S. aureus model was experimentally advantageous because the infection remained localized to the wound without systemic infection or signs of discomfort. The S. hyicus infection caused a rash with skin blisters; thus, its use is discouraged. The concentration of S. hyicus in the wound on day 2 was log 8.6 +/- 0.4 CFU/g (mean +/- standard deviation). On day 4 the mean was log 9.2. For S. aureus the values were log 8.0 +/- 0.9 on day 2 and 6.9 on day 4 (p less than 0.05). Of the 50 individual values in the S. aureus series, 45 were above log 5. The inflammatory reaction was more pronounced after the infection with S. hyicus, whereas with S. aureus the fibroblast response came earlier and was more pronounced. The model parallels typical clinical courses of staphylococcal infection.

Animals↗
PubMed1988

Non-traumatic brain abscess. Epidemiology, clinical symptoms and therapeutic results.

Two groups of patients with non-traumatic focal intracranial suppurative diseases were studied retrospectively to illustrate epidemiology, clinical symptoms and therapeutic results. The first group consists of 87 patients treated for brain abscess in the Department of Neurosurgery in Lund. During the 36-year period investigated (1947-1982) marked epidemiological changes occurred. Thus otogenic abscesses, constituting 33% of the cases below the age of 30 during the first 12 years of the study, virtually disappeared. During the third 12-year period of this study a marked increase in the number of abscesses was noted. The increase was caused particularly by the number of cryptogenic abscesses amounting to 51% of the material during 1971-1982. The second group of patients consists of all patients with pre- or post-mortem diagnosed brain abscess in the city of Malmö during 1960-1981. Since during this period 85% of all persons who died in this city were subjected to post-mortem examination this material offers a unique possibility of epidemiological studies. The combined study of these two groups of patients lends no support to the view that a real increase in the number of brain abscesses has occurred. We conclude that in patients with cryptogenic brain abscess the clinical symptoms do not usually indicate the presence of an infectious disease. In the majority of these patients a correct diagnosis has presumably not been obtained until the last decade. Furthermore, the investigation confirms the view that a mortality below 10% is nowadays feasible in unselected cases of brain abscess.

Brain Abscess↗
PubMed1984

A histologic comparison of experimental microarterial end-in-end (sleeve) and end-to-end anastomoses.

Twenty-five microvascular end-in-end and 21 end-to-end anastomoses were performed on the central arteries (diameters 0.8 to 1.2 mm) of rabbit ears. The appearance of longitudinal specimens taken after intervals of 1 to 2 hours and 1, 3, 7, 14, 30, and 90 days was studied microscopically. Between 1 to 2 hours and 14 days, all end-in-end anastamoses showed considerable narrowing of the telescoped segment, and platelets had accumulated at the sleeved vessel end. The vascular walls of the telescoped segment were thickened distally, and the internal elastic laminas were folded in the lingitudinal direction due to contraction. Extensive loss of endothelium was observed both around sutures and distally in the telescoped segments. The stenosis initially noted in telescoped vessels gradually decreased due to atrophy of the medial layers in the double vascular walls. Following the organization of the platelet aggregates, subsequent endothelialization was completed between 7 and 14 days. After 2 weeks, neointimal hyperplasia was frequently found at the sleeved vessel end. In the early postoperative period, platelets covered exposed subendothelial structures and sealed defects in the vessel walls of all end-to-end anastomoses. During the first few postoperative weeks, the medial layers disintegrated and were replaced by increasing fibrosis. Reendothelialization was completed between 7 and 14 days, whereafter gradual intimal hyperplasia became significant.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

Growth and function of human placenta and amnion grafted to nude mice. A preliminary communication.

Normal human placenta and amnion from the 20th week of pregnancy were transplanted into nude mice. The transplants retained the histological and immunohistochemical picture of the original tissue and maintained synthesis of human chorionic gonadotropin (hCG), pregnancy-specific beta 1-glycoprotein (SP1), GnRH and placental proteins PP5, PP11 and PP12 for 5 weeks. This experimental model has a wide potential application for studies on placental protein synthesis and the hormonal influence of human placenta on other simultaneously transplanted human tissues.

Amnion↗
PubMed1983

Occult bleeding from giant small-bowel diverticula.

Two cases of occult intestinal blood loss due to giant ileal diverticula are described. In one of them, ectopic gastric mucosa was found at microscopic dissection. In the other that was probably originating from a blind loop formation at a previous operation, multiple mucosal erosions, probably due to retained bowel contents, were considered responsible for the blood loss. Though giant diverticula are rare throughout the gastrointestinal tract, and usually cause symptoms other than bleeding, the importance of a careful search for this malformation in children with occult faecal blood loss is stressed.

Adolescent↗
PubMed1980

Methacycline hyperpigmentation: a five-year follow-up.

A five-year follow-up is presented of a unique material of patients who acquired a greyish black hyperpigmentation during long-term methacycline therapy for chronic bronchitis. The melanosis disappeared in cases in which tetracycline therapy was discontinued during the observation period but not in those in which doxycycline had been substituted. In two autopsy cases pigment deposits were also found in cartilage and atherosclerotic lesions. Overall clinical and microscopic findings suggest a similarity to the pigmentation occurring in iatrogenic ochronosis.

Bronchitis↗
PubMed1978

Type I congenital dyserythropoietic anaemia with myelopoietic abnormalities and hand malformations.

Type I dyserythropoietic anaemia was diagnosed in an infant, who presented with respiratory distress and hepatosplenomegaly soon after birth. Anaemia became manifest during the neonatal period. The case clearly proves the congenital nature of the disease. Abnormalities of the myelopoietic series indicate that it might be a stem cell disease and the presence of skeletal anomalies of the hands suggests a genetic relationship to some cases of Fanconi and Diamond anaemia. No serum lipid or vitamin E deficiency was present as in type II congenital dyserythropoietic anaemia. Serial serum ferritin determinations indicated that iron stores are increased early in type I congenital dyserythropoietic anaemia despite no transfusion load.

Anemia↗
PubMed1978

Human ovarian tumours heterotransplanted to "nude" mice.

22 different human ovarian tumours were heterotransplanted subcutaneously to female "nude" mice. When small tissue pieces were used 10 out of 16 tumours grew. Subcutaneous injections of suspended tumour cells were made to 11 mice: all failed. Metastatic or infiltrative growth was never seen in the mice observed for up to 25-40 days. Material from each tumour was transplanted to four separate sites in two mice. The successful grafts largely retained the original morphological features. As measured with H3-thymidine incorporation, DNA-synthesis was also similar in the original tumours and the growing grafts. This animal in vivo model might be highly informative for the study of inter alia fundamental biology, chemotherapy, and irradiation of ovarian tumours.

Animals↗
PubMed1977

The angiographic appearance of thymic tumors.

Angiography of the internal mammary artery was performed in 30 patients with suspected tumors in the anterior mediastinum. In 3 patients, thymic venography was also performed. In 13 lymphoepithelial thymomas, a smooth outline with the arteries penetrating the periphery of the tumor was demonstrated. Frequently, neovascularity but never encasement of large arteries or arteriovenous (AV) shunting was exhibited. In the lymphoepithelial thymomas of the cell-rich type, the accumulation of contrast medium and neovascularity were pronounced. This type of thymoma may possibly be locally more invasive than others. In carcinomas, the arteries penetrated the tumor and AV shunting was common. Arteriography was superior to venography in the few patients in whom both examinations were performed. Angiographically, it should be possible to differentiate thymomas from carcinomas.

Adult↗