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Biomedical subjects

A Rauff

Publications and source records attributed to A Rauff.

At least 19 recordsLinked to original sources
PubMed2005

Parathyroid carcinoma: a case series.

INTRODUCTION: We present 3 patients with parathyroid carcinoma and describe their presentations, clinical profiles, and management. MATERIALS AND METHODS: A case series review of medical records. RESULTS: Two women and 1 man (age range, 32 to 57 years) had parathyroid cancer and primary hyperparathyroidism (PHPT). One patient presented with osteitis fibrosa, 1 with renal stone and a neck mass, and 1 with recurrence of PHPT after excision of supposedly benign parathyroid adenoma 4 years ago. All had severe hypercalcaemia and elevated parathyroid hormone levels that ranged from 4 to 43 times above the normal range. Exploration of the neck clearly identified 1 parathyroid tumour with local invasion; 2 other specimens showed capsular and vascular invasion on frozen section and final histology. All 3 patients underwent parathyroidectomy and ipsilateral hemithyroidectomy. Parathyroid size ranged from 1.3 to 4 cm and no lymph node metastasis was identified. No patient had tumour recurrence after a follow-up period of 1 year. CONCLUSION: Parathyroid carcinoma is a rare endocrine malignancy. Suspicious features include marked hypercalcaemia, neck mass, and local recurrence. Parathyroidectomy with ipsilateral hemithyroidectomy and nodal clearance gives the best chance of reducing local tumour recurrence.

Adult↗
PubMed1996

Nitric oxide synthase activity and expression in human colorectal cancer.

The present study investigated the activity and cellular localization of individual isoenzymes of nitric oxide synthase (NOS) using immunohistochemistry and the [3H]citrulline assay in normal colorectal epithelia and neoplastic tissue. Intracellular localization of isoenzymes of NOS was detectable by immunohistochemistry in normal epithelial cells. Colorectal adenocarcinomas had a marked reduction of both Inducible NOS (iNOS) and constitutive NOS (cNOS) expression. Expression of iNOS was completely absent in tumour cells (P < 0.0001), while cNOS was reduced in 66% and absent in 34% of tumours studied when compared with controls (P < 0.0001). NOS activity using the [3H]citrulline assay was detectable in normal epithelium and was found to be reduced in tumours (P < 0.001). In addition, colonic adenomas had reduced INOS but not cNOS expression when compared with controls (P < 0.003 and P = 0.39 respectively). We conclude that NOS is present and active within the epithelium of the normal colon, with localization of the individual isoenzymes. Furthermore, there was loss of activity and expression of individual isoenzymes in colonic neoplasms.

Adult↗
PubMed1993

Diagnostic laparoscopy: reducing the number of normal appendectomies.

A prospective, controlled study was conducted to determine whether a selective policy of diagnostic laparoscopy could reduce the number of unnecessary normal appendectomies in patients with acute right iliac fossa pain. The cohort consisted of patients admitted with acute right iliac fossa pain by the emergency department. Of 102 patients in the study group, 28 subsequently required a diagnostic laparoscopy when a definite diagnosis could not be reached after 8 to 12 hours of observation. Of these, only 18 had inflamed appendices, which were removed. In the rest of the patients (10), the appendices were normal and unnecessary laparotomies were avoided. In the control group, wherein equivocal cases were laparotomized after a similar period of observation, there was a normal appendectomy rate of 15.7 percent (P < 0.05). There was no significant difference in the incidence of perforation between the control and study groups. Diagnostic laparoscopy in equivocal cases could thus significantly reduce the number of unnecessary appendectomies without compromising on the rate of perforation.

Adolescent↗
PubMed1993

Elderly patients with perforated peptic ulcers: factors affecting morbidity and mortality.

Morbidity and mortality of perforated peptic ulcers (PPUs) have been higher when they occur in elderly patients. Seventy-three PPUs were reviewed to determine the factors accounting for the poor outcome in patients at or above 65 years old (elderly PPU). The presentation of 44 young PPUs was compared to 29 elderly PPUs. Delay in diagnosis, associated comorbid factors and shock on admission were found to be the primary factors. There was a significant difference between the two groups in terms of duration of pain before the diagnosis was made (8.2 h vs 16.4 h) (P < 0.05). The delay in diagnosis was partly due to the vague presentation, as 41.4% (11 patients) of the elderly presented with abdominal pain not localized in the epigastrium. In addition, 55.2% (16) of elderly patients did not have a history of prior ulcer disease and one-third (nine) did not have air under the diaphragm on chest X-ray. Significant comorbid factors were present in 65.5% compared to 15.9% in the younger group (P < 0.001). Shock on admission was present in six (20.7%) elderly patients, but only in one (2.3%) young patient (P < 0.05). As a result, morbidity was 89.6% in the elderly group compared to 27.2% in the younger patients (P < 0.001). Wound complications accounted for a significant proportion of the morbidity. Mortality was 17.2% and 2.3% respectively (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1993

Carcinoma of the pancreas--bypass versus resection?

The surgical treatment of carcinoma of the pancreas remains controversial. Over a 5-year period, 38 patients with histologically proven carcinoma of the pancreas who were operated on were studied to assess the length of survival. Seven were subjected to a 'curative' resection, 27 subjected to a palliative bypass procedure and four had a laparotomy and biopsy only. The mean survival was 8.7 months for the first group, 8.1 for the second and only 1.6 for those subjected to a laparotomy and biopsy only.

Adenocarcinoma↗
PubMed1993

Gall bladder empyema--another good reason for early cholecystectomy.

Over an 18-month period, 31 cholecystectomies were performed for empyema of the gall bladder. Analysis of these 31 cases showed that clinical features referable to the diagnosis and seriousness of this condition were few. The presence of a gall bladder mass was detected in only 35% of patients. In adopting a policy of early cholecystectomy for patients admitted for acute gall bladder disease, a low mortality rate of 3.2% was achieved for this group of patients with empyema of the gall bladder. Based on these results, we found that empyema of the gall bladder is another good reason to support early cholecystectomy.

Adult↗
PubMed1993

Primary gastric lymphoma.

Primary gastric lymphoma is a rare gastrointestinal lymphoma. The treatment of this condition remains controversial, especially the extent of surgical resection. Ten cases were operated on over a five-year period at our institution and the outcome was reviewed. Early results suggest no difference in survival whether the margin of resection was clear or not so long as postoperative chemotherapy was given. The outcome appear to depend more on the extent of the disease at the time of surgery. Full thickness involvement of the stomach wall with lymph node involvement were bad prognostic indicators.

Adult↗
PubMed1993

The solitary thyroid nodule revisited.

A series of 195 clinically solitary thyroid nodules is presented and compared with a matching series reported a decade ago. Changes in the pattern of presentation, preoperative diagnosis and options of operative management are highlighted. Although the pattern of presentation has not changed significantly over the last decade, there was a shift noted towards reliance on fine needle aspiration for preoperative diagnosis. The false negative rate was two percent in this series and there were no false positives. There was also a shift towards more conservative surgery in the form of "nodulectomies" in the present series compared to the previous one. The incidence of malignancy in this series was 10.2 percent.

Adolescent↗
PubMed1993

Changing patterns in the treatment of early breast cancer: a historical perspective and a review of changing local trends.

Over the past 50 years, a variety of surgical procedures have been advocated for the treatment of operable breast cancer, ranging from local excision to supraradical mastectomy. Today, the surgical treatment of breast cancer remains highly contentious. We review the historical development of breast cancer surgery and analyse the available evidence supporting conservative procedures. We also express our opinions on the treatment of early breast cancer and illustrate the changing patterns of surgery with our experience at National University Hospital.

Breast Neoplasms↗
PubMed1993

Primary repair of iatrogenic colonic perforations in unprepared colon--a report of five cases.

Primary repair of iatrogenic colonic perforations sustained during pelvic surgery was successfully undertaken in five consecutive cases who did not receive pre-operative bowel preparation. A proximal diverting colostomy was not performed following the repair. There were no instances of intra-abdominal abscess or colonic fistulation. One case developed wound infection. Post-operative recovery in all cases were mostly uneventful with a mean post-operative ileus of four days and a stay of ten days. Primary repair of iatrogenic colonic perforations in unprepared colon can be safely undertaken without a proximal diverting colostomy with acceptable morbidity.

Adult↗
PubMed1992

Surgical management of right colon diverticulitis.

The infrequent occurrence of right colon diverticulitis in the developed West has led to a controversy in the management of this disease. In Singapore, we continued to avoid colectomy whenever possible because this disease is usually nonprogressive. We reviewed 68 patients treated by conservative surgery to evaluate the effectiveness of this treatment policy. Almost 70 percent of our patients were below 40 years of age, and the clinical presentation was indistinguishable from acute appendicitis. Diverticulectomy was done only for inflamed and perforated diverticula (25 cases), while the nonperforated diverticulum was left alone (40 cases). The inflammation invariably responded to antibiotic therapy. Only three patients had colonic resection since a malignant neoplasm could not be excluded. There were no adverse sequelae over a mean follow-up period of three and one-half years, except for one patient who had recurrent attacks of right colon diverticulitis necessitating colectomy. With this policy of management we encountered no mortality, and morbidity was acceptable.

Adult↗
PubMed1992

A study of 245 infected surgical wounds in Singapore.

The aims of the study were to correlate the laboratory detection rate of wound infections with the actual wound infection rate, and to analyse the bacteriology of these wounds to provide a rationale for antibiotic usage in prophylaxis and treatment of surgical wound infections. The wound infection rate in a general surgical unit was determined using the most comprehensive surveillance available to us and was correlated with the laboratory detection rate. A correlation coefficient of 0.8 was obtained, allowing a reasonable estimation of the actual wound infection rate from laboratory data. Review of the bacteriology of consecutive infected surgical wounds over a 4 year period in a university hospital, revealed that the commonest organisms cultured were Staphylococcus aureus, Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, enterococci and beta-haemolytic streptococci. Methicillin-resistant S. aureus (MRSA) caused 50% of all staphylococcal wound infections. All MRSA isolates were sensitive to fusidic acid and vancomycin. All the non-MRSA isolates of S. aureus were sensitive to cephalexin. Some 89% of E. coli were sensitive to gentamicin, with 93% and 100% sensitive to cefuroxime and ceftriaxone respectively. Klebsiella isolates have shown an increased resistance to aminoglycosides, with a new strain from one patient, isolated in 1990, resistant to penicillins, aminoglycosides and third generation cephalosporins. Pseudomonas spp., enterococci and beta-haemolytic streptococci did not show a change in resistance patterns over the same time period.

Anti-Bacterial Agents↗
PubMed1992

Splenic abscess.

Isolated splenic abscess is an uncommon condition. Seven cases seen between 1980 and 1990 are reviewed. The clinical presentation is non-specific and diagnosis is usually delayed. Computerized tomography allowed for accurate diagnosis in all cases. Pseudomonas species as a causative organism is reported to be rare, but were present in three of the present cases. Antibiotic therapy alone is insufficient and splenectomy remains the treatment of choice.

Abscess↗
PubMed1992

A descriptive study of emergencies admitted to a surgical department.

A study was undertaken to evaluate the pattern of emergency admissions and their management by the surgical firm in a medium size (700 beds) general hospital. Over a three month period, 258 patients were admitted to one surgical team that was on take every third day. All patients were entered into a protocol that was updated daily by a registrar. In four (13.3%) of the 30 days on take, patients had to be referred to a nearby hospital due to shortage of emergency beds. The accuracy of diagnosis by the Accident and Emergency (A&E) resident, surgical resident and surgical team were 75.7, 77.2 and 88.4% respectively. The mean delay before attendance by an intern after admission was 47 (SD +/- 29) mins. Forty-four (17%) of these admissions were probably unnecessary. A further 22 (8.5%) patients had to be referred to other disciplines, indicating an initial wrong diagnosis. A substantial number of investigations were unnecessarily done on an emergency basis. Ninety-three (36.0%) patients required surgery. The median duration of hospital stay was three days. The overall morbidity was 4.2% and mortality 1.2%. The study was valuable in revealing the deficiencies in the existing emergency service; leading to new proposals to achieve our ultimate aim of providing high quality patient care.

Adult↗