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Biomedical subjects

A Raspiller

Publications and source records attributed to A Raspiller.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Acute choriocapillaris occlusion in pregnancy and puerperium. Toxemias, thrombotic microangiopathies].

Six cases of gravidic toxemia (4) and thrombotic thrombocytopenic purpura (Moschowitz's disease) in puerperium with choriocapillaris occlusion, were examined. At the acute stage, the vision is improved, ophthalmoscopy of the fundus revealed cystlike bullous exudative subretinal with retinal detachment, yellowish spots (of retinal pigment epithelium) and often minimal localized arteriolar narrowing. The evolution included retina application pigmentary disturbances and Elschnig's spots. Fluorescein angiography showed delayed filling of the capillaris and dye leakage in the subretinal space (first hypofluorescence and late hyperfluorescence). There are various stages of ischaemic involvement but in all cases visual symptoms may be due to central obstructive choroidopathy with delayed filling and occlusion. The retinal detachment in toxemia or Moschowitz disease in pregnancy in secondary to microcirculatory choroidal damage (short ciliary vessels essentially) with rupture of blood retinal barrier. Other constatations are made in disseminated intravascular coagulation, periarteritis nodosa, accelerated nephrosclerosis, hemolytic uremic syndrome in puerperium, and these suggested possible relationship between the various conditions.

Choroid↗
PubMed1983

[A new etiology of episcleritis: nephropathies with IgA and/or isolated C3 deposits].

Scleritis is a condition of the eye often associated with systemic diseases, allergy and infections. Nomoto et al. have reported the frequency of episcleritis in patients with IgA nephropathy (Berger's disease), a primary glomerulonephritis initially described by Berger in 1968. It is characterized by mesangial deposits of IgA, and is considered one of the most frequent nephritides in France. We report our study of the association of scleritis with glomerulonephritis (GN). Fifty-three GN patients were examined for the presence of scleritis. The exact type of nephropathy in each patient was determined by a renal biopsy and immunofluorescence studies. Episcleritis was found in 10 GN patients: in 5 out of 27 Berger's disease, 3 out of 4 patients with isolated mesangial C3 deposits, 1 out of 2 patients with membraneous GN, and 1 out of 5 patients with membranoproliferative GN. The finding of episcleritis in 18% of patients with IgA nephropathy is very similar to the results reported by Nomoto et al. (15%). As no other cause of episcleritis was found in these positive patients, the ocular lesion may be considered to be related to their GN. Episcleritis patient had no abnormal levels of serum IgA, but circulating immune complexes activating the alternate pathway of the complement system were present in most of them. In one female patient with Berger's disease and frequent episodes of episcleritis, an episcleral biopsy was obtained for immunohistological studies. Large numbers of dimeric IgA secreting plasma cells were observed in this tissue. These results suggest the involvement of ocular surface immunity in some cases of IgA nephropathy. It might therefore be useful to investigate the renal function of patients presenting recurrent episodes of episcleritis.

Complement C3↗
PubMed1983

[Serous macular detachment of the neuro-epithelium and flumequine].

Flumequine (1 200 mg/day) was prescribed as treatment for infection of the urinary tract to three patients with chronic renal failure, who reported positive scotoma three days later. Ophthalmologic examination evinced bilateral symmetrical macular bullae. A characteristic yellow papule was present at foveal level. In all three cases, visual acuity was impaired (down to 4/10), without any angiographic alteration. Foveolas showed a moderate persistent hyperfluorescence. All patients recovered a normal visual acuity, within two days after treatment cessation, and bullae disappeared without sequelae within 5 days. The chronology and kinetics of clinical manifestations were clearly and reproducibly correlated with flumequine therapy in all patients, and suggest that this drug may be considered responsible for the ocular symptom reported. Chronic renal failure (creatinine clearance lower than 25 ml/mn) most certainly favoured the appearance of visual troubles, but other factors may possibly play a similar role: hepatic failure, individual hypersensitivity... Quinolones used as urinary antiseptics (nalidixic acid, oxolinic acid, pipemidic acid...), and other flumequine analogues may possibly be involved in such side-effects. This was reported by Bouissou et al. in an experimental model with nalidixic acid, where transient bullae appeared on young animals' articular cartilage. Such lesions are related to focal alterations of the C2 intermediary layer of cartilage, with marked edema of the interstitial material. The volume of synovial fluid increases concomitantly. These alterations suggest a direct cytotoxic effect at the intercellular level of target organs, a mechanism possibly also occurring in the retina.

Adult↗
PubMed1982

Association of del(11)(p15.1p12), aniridia, catalase deficiency, and cardiomyopathy.

We report another patient with del(11p) and aniridia, catalase deficiency, and cardiomyopathy. This association is confirmed from a review of previously reported cases. Since other dysplasias are known in this syndrome, the hypertrophic cardiomyopathy in del(11p) children may also represent an abnormality of tissue development.

Abnormalities, Multiple↗
PubMed1982

[The vascularization of the anterior portion of the medial rectus muscle after a Cupper's thread operation].

Development of vascularization of the anterior part of the medial rectus muscle after Cüppers' thread operation was studied by injected barium sulphate into the ophthalmic artery of 8 corpses. Properly distributed and normally tightened myoscleral sutures, as with surgical operations for strabismus, do not hinder circulation of the contrast medium, whereas markedly tightened sutures interrupt its circulation. These experimental results as well as clinical and pathological findings following 18 repeat surgical operations, clearly show that Cüppers' thread operation is not hazardous when a very strict operative technique is respected.

Cadaver↗
PubMed1981

[Arterial vascularization of the musculi rectus verticalis and obliquus oculi (author's transl)].

In a recent article, we described arterial vascularization of the musculi rectus medialis and lateralis, using a radiological technique. We have now studied, in the cadaver, arterial vascularization of the musculi obliquus and rectus verticalis, from 30 new orbital contents. The posterior two thirds of the ocular face of each muscle and its edges are particularly rich in vascular inlets. The musculus rectus superior often has one pedicle only, in the shape of a tuning fork, stretched over nearly the whole length of the muscle. The musculus rectus inferior often has only a single central pedicle clearly visible in the anterior third of the muscle only. The musculus obliquus superior has two vascular sources which form one or two central axes. The arrangement of the arterioles in the musculus obliquus inferior is always the same, the main point of entry being located in the middle of the posterior face of the muscle. The anterior eiliary arteries in arising the two musculi rectus verticalis, are particularly large.

Adult↗