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Biomedical subjects

A Raspiller

Publications and source records attributed to A Raspiller.

At least 19 recordsLinked to original sources
PubMed1998

[Small retinal, cochlear, and cerebral infarctions in the young patient, "SICRET" syndrome of Susac syndrome].

A 22-year-old-lady presented with multiple occlusions of the branches of the central retinal artery, accompanied by neuro-encephalic disorders and deafness. This triad is known as SICRET Syndrome (Small Infarction of Cochlear, Retinal and Encephalic Tissue). This rare syndrome, as well referred to as Susac syndrome, affects only the women and the three tissues mentioned above: eye, ear, brain. The course was characterised by a series of partially regressive evolutive steps. A remission had been obtained since two years with immuno-supressor and anti-coagulant therapy. The neuro-encephalic and cochlear disorder regressed in contrast to the severe sequel on the right eye.

Adult↗
PubMed1998

Coincident resection-recession (tenectomy-recession) of the medial rectus muscle, bilaterally, for the treatment of esotropia: results in 18 cases.

PURPOSE: To study the effect of preceding tenectomy of the medial rectus tendon on the results of medial rectus muscle recession. SUBJECTS AND METHODS: Eighteen consecutive cases of incomitant esotropia were retrospectively reviewed. The average preoperative esotropia was 35 PD with an incomitant deviation between 10 PD and 30 PD. All patients underwent 7 mm bilateral medial rectus muscle recession after 4 mm tenectomy of the anterior medial rectus muscle. RESULTS: Fourteen patients (78%) had "satisfactory" results (within 10 PD static esodeviation and 12 PD dynamic deviation [incomitance]). Four (22%) were undercorrected. One showed a postoperative consecutive exotropia of 4 PD at distance only. CONCLUSIONS: Tenectomy of the anterior muscle tendon preceding large recessions of the medial rectus was effective in reducing the frequency of overcorrection (consecutive exotropia). Undercorrection did not appear to be more common.

Child↗
PubMed1996

[Treatment of vitreoretinal proliferation in rhegmatogenous detachment and silicone oil tamponade].

PURPOSE: To describe our technique of vitrectomy and silicone oil tamponade for managing retinal detachment and to report the last results according to the posterior and anterior proliferative vitreoretinopathy. METHODS: A retrospective study was conducted in 108 patients who underwent vitreoretinal surgery and silicone oil tamponade for proliferative vitreo-retinopathy, 64% patients had already been operated without success and 42% underwent vitrectomy with SF6 or C3F8. Diffuse posterior proliferative vitreo-retinopathy (grade C3-D) was present in 64% patients and anterior proliferative vitreoretinopathy was present in 43.5%. Silicone oil was removed in 79% patients after a mean duration of 6.3 months. It was replaced by 16% C3F8. All patients were followed for a minimum of 6 months. RESULTS: Before silicone oil removal, 55% of the retinas were reattached posterior to the scleral buckle with one operation, 78% after 2 operations and 88% after 3 or 4 operations. An average of 2.1 vitrectomy surgeries were performed. Reproliferation was correlated with the anterior proliferative vitreo-retinopathy (p < 0.001), posterior proliferative vitreo-retinopathy (p < 0.01) or previous vitrectomy (p < 0.05). The final visual acuity was 1/20 or better in 61% of the eyes and 2/10 or better in 30.5%. After silicone oil removal, 8% retinas redetached, 21% of the eyes had hypertony, 7.5% had hypotony and 7% of the corneas had dystrophy. CONCLUSION: Silicone oil tamponade was effective for the treatment of retinal detachments with proliferative vitreo-retinopathy. Since the main complications were hypertony and corneal dystrophy, silicone oil should be reserved for severe proliferative vitreo-retinopathy cases.

Adult↗
PubMed1995

[Ocular vasospasm in cold provocation test and primary vascular acrosyndrome].

An ocular vasospasm induced by cold has been searched among 8 patients carrying primary vasospastic disease without any ocular pathology. Ocular vasospasm which is characterized by visual field defect was searched with Statpac 24-2 test using HUMPHREY autoperimeter. A baseline visual field was performed first, then a second after provocation by dipping the hand in cold water (13 degrees) and a third after oral administration of 10 mg of Nifedipine. Two patients had ocular vasospasm that regressed after Nifedipine administration. These two patients might have a higher risk to develop normal tension glaucoma.

Adult↗
PubMed1992

[Efficacy and tolerability of apraclonidine (ALO 2145, 1%) in the prevention of early ocular hypertonia, after trabeculoretraction using argon laser and posterior capsulotomy using Nd:YAG laser].

ALO 2145 (Apraclonidine Chlorhydrate)*, is a new hypotensive agent; it acts as a selective alpha-2-adrenergic agonist to produce a marked reduction in intraocular pressure with minimal effect on the cardiovascular system. 38 patients undergoing ocular laser surgery were allocated to treatment with either ALO 2145 1% (n = 20), or to placebo (n = 18), in a double-masked fashion. One drop of study medication was instilled into the operative eye one hour before laser surgery, and one drop immediately after the laser surgery. ALO 2145 treated eyes exhibited a significantly lower mean intraocular pressure increase in the immediate postoperative phase, compared with placebo treated eyes. ALO 2145 also significantly reduced the postoperative incidence of intraocular pressure spikes, defined as intraocular pressure increases of more than 10 mmHg over baseline (17% of cases for active treatment vs 60% of cases for placebo). ALO 2145 1% was shown to be effective and well tolerated in the dosage regimen employed in this study.

Adrenergic alpha-Agonists↗
PubMed1990

[Chorioretinitis in congenital toxoplasmosis].

The goal of this study was to establish the incidence of chorioretinitis in 100 infants whose mothers presented a seroconversion during the pregnancy. It is a retrospective study over 6.5 years. There were 17 cases of latent congenital toxoplasmosis (56.7%) and 13 cases of clinical congenital toxoplasmosis (43.3%). Three infants presented with chorioretinitis: one at birth in a context of general stroke, the two others at 2 and 17 months after birth, despite treatment. The risk of retinochorioditis was the same in the case of latent or clinical congenital toxoplasmosis. The fall in the antibody titre was not a good criterion of cure; the percentage of lymphocytes in the cerebrospinal fluid could constitute a better criterion. This study confirmed the efficacy of systemic treatment of congenital toxoplasmosis.

Antibodies, Protozoan↗
PubMed1990

[Pneumatic retinopexy using SF6 or C3F8. Results and complications apropos of 56 patients].

56 patients with primary retinal detachment were treated by pneumatic retinopexy. The overall success rate for reattachment with one operation was 66%. Postoperative complications included development of new tears (18%) and P.V.R. (16%). Pneumatic retinopexy is a valuable new technique, however careful patient selection and postoperative management is required.

Adult↗
PubMed1989

Visual evoked potentials in diabetic patients.

Visual evoked potentials (VEPs) were assessed in 50 adult type I (insulin-dependent) and 19 type II (noninsulin-dependent) diabetes mellitus patients and in 54 controls. P100 wave latency was significantly longer in diabetic patients (P less than .001). Twenty-eight percent of diabetic patients had P100 wave latencies above the normal range. There was no correlation between P100 latency and type or duration of diabetes mellitus, quality of metabolic control, or presence of degenerative complications. The significance of VEP abnormalities in diabetes mellitus remains speculative.

Adult↗
PubMed1989

[Evaluation of the histopathologic effects following subconjunctival injection of corticoids in immediate- and retard-action forms].

We comparatively studied histopathologic impairments following subconjonctival injections of long and short acting corticosteroids and saline. 44 conjunctival biopsies were performed in the site of injection. The tissues were evaluated by light and electron microscopy. The histopathologic findings, following saline subconjonctival injection were very slight. On the other hand, histopathologic findings following corticoids injection, and particularly long action products, were remarkable. We noted crystalline deposits inclusions of drug particles in fibroblast and macrophages, loss of collagen definition and degenerative changes of these phagocytosing cells, with release of their cytoplasmic contents. Our findings are according with previous studies about long acting corticosteroids, supporting their relative histologic toxicity, by local way of administration.

Betamethasone↗
PubMed1989

[Early endothelial complications after treatment using a neodymium-Yag laser].

The authors analysed the corneal endothelium after Neodymium-Yag laser treatment. The Visulas-Yag laser was used. The endothelial study was performed by the specular microscopy (Pocklington). The study included 46 patients divided into 2 groups: in the first group, 33 eyes had a capsulotomy (17 aphakic and 16 pseudophakic): in the second group, 13 eyes had an iridotomy (3 pseudophakic and 10 phakic). In the group of capsulotomies, the energy used for the impact was 2.6 +/- 0.7 mJ and the total energy was 110 +/- 80 mJ. The cellular loss was 7.4% on the third day and 6.5% by the third month. In this series the cellular loss of aphakic patients was 8.1% on the third day and 5.9% by the third month. In the pseudophakic patients, the loss was 6.5% on the third day and 7.3% by the third month. There was a significant correlation between the endothelial cell loss and the total energy delivered (r: 0.42: p less than 0.02). In the group of iridotomies, the energy for each impact was 3 +/- 1.3 mJ and the total energy was 118.7 +/- 92 mJ. The cellular endothelial density decreases to 7.4% the third day and to 3.8% by the third month. There was no significant correlation between the endothelial cell loss and the total energy delivered. Immediately after the treatment by Neodymium-Yag laser, there were round dark endothelium wounds near the treated zone. They may put into question the functional prognosis by the treated eye.

Cell Count↗
PubMed1989

[Uveal effusion syndrome. Apropos of a case].

Uveal effusion syndrome is a rare entity. It associates a nonrhegmatogenous retinal detachment, an annular cilio-choroïdal detachment and peripheral vascular anomalies. It is important to differentiate it from the another retinal detachments and the malignant melanoma.

Exudates and Transudates↗
PubMed1988

[Endothelial morphometry and perforating keratoplasties].

50 corneal grafts were studied by specular microscopy. The endothelial cell morphology of the grafts was analysed by using a computerised image analysis system. The endothelial cell density decreased rapidly during the first three post-operative months (17%). It continued to decrease for the first year (52%, after which cell loss occurred at a slower rate (3% of the sample cell count per year). The coefficient of variation in cell area remained constant (27%). The percentage of endothelial cell loss might be closely associated with the reestablishment of the hexagonal cellular pattern. These results suggest that the endothelium of the graft is in a state of transition during the first year after surgery.

Adult↗