Search PubMed⌕ Search

Biomedical subjects

A Rashid

Publications and source records attributed to A Rashid.

184 records · Page 11Linked to original sources
PubMedDate not supplied

Papillary muscle rupture following nonpenetrating chest trauma: report of a case with hemodynamic and serial echocardiographic findings and successful surgical treatment.

The pre- and postoperative echocardiographic features of a patient with severe mitral incompetence due to rupture of a papillary muscle following nonpenetrating chest trauma are presented. The mitral valve echocardiogram showed chaotic diastolic flutter suggestive of a ruptured papillary muscle or ruptured chordae tendineae. The preoperative ultrasound recording of the left ventricle revealed left ventricular enlargement and excessive motion of the interventricular septum. The echocardiogram taken 7 weeks after mitral valve replacement showed considerable regression of the left ventricular enlargement.

Adult↗
PubMedDate not supplied

Activity of terbinafine on Trichophyton mentagrophytes in a human living skin equivalent model.

Germination of arthroconidia of Trichophyton mentagrophytes in the presence of the allylamine antifungal terbinafine was assessed utilizing a human living skin equivalent model. Arthroconidia were inoculated onto the skin-equivalent previously exposed to low concentrations of terbinafine (0.01-1.0 mg l-1) and then incubated at 28 degrees C for 7 days. An assessment of fungal growth inhibition was made by light and scanning electron microscopy. In the absence of terbinafine, adherence, germination and hyphal extension were observed. Penetration of the model was seen, with hyphae present in the dermal component. In the presence of terbinafine, inhibition of fungal growth was apparent and the drug was seen to act as a barrier against fungal invasion of the dermis. The data indicate that the living skin equivalent model is a promising in vitro system for evaluating new antifungal agents.

Antifungal Agents↗
PubMedDate not supplied

An in vitro model of dermatophyte invasion of the human hair follicle.

A novel in vitro model for the study of hair invasion by Trichophyton mentagrophytes was developed. Hair was obtained by microdissection and plucking. Following inoculation of the hair follicle with arthroconidia growth of the fungus was seen on the hair and within the follicle. Growth was observed to begin at the shaft end and to extend along the hair shaft towards the bulb area. In follicles maintained in organ culture the inner root sheath in particular was invaded by T. mentagrophytes and provided a good substrate for fungal growth. Initially, the cuticle formed a barrier to fungal penetration of the hair. After incubation for 4 days, germlings of T. mentagrophytes were seen to penetrate under the cuticle and in between the layers of cuticular cells to invade the cortex. There was no evidence of intracellular growth; fungal elements were seen intercellularly. There were similarities between the findings in this study of the process of hair invasion by dermatophyte fungi and that in the natural disease.

Adult↗