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Biomedical subjects

A Raine

Publications and source records attributed to A Raine.

At least 19 recordsLinked to original sources
PubMed1997

Neuropsychological and psychophysiological correlates of psychosocial functioning in schizophrenia.

This study tested hypothesized relationships between neuropsychological and psychophysiological variables and concurrent levels of clinical and psychosocial functioning in schizophrenia. The sample consisted of 40 subjects diagnosed with a chronic schizophrenia spectrum disorder and living in community-based settings. The psychophysiological variables were tonic skin conductance (SC) level, SC reactivity to stressors, and SC response to orienting stimuli. The neuropsychological measures were the Stroop, the Controlled Word Association Test, and four subtests of the Wechsler Adult Intelligence Scale-Revised (block design, digit symbol, digit span, and arithmetic). The psychosocial variables were measures of symptomatology, independent living, work, and social functioning. The results suggested that higher symptoms were associated with higher resting arousal, lower stress reactivity, status as an electrodermal responder, and deficits in verbal fluency and visuo-motor functioning. The pattern for better social functioning was higher resting arousal, lower stress reactivity, and more responses to orienting stimuli. Higher levels of independent living were associated with better visuo-motor and verbal processing. Increased work functioning was associated with better complex visuo-spatial processing. These findings are discussed in terms of (1) the specificity of associations between psychosocial, psychophysiological, and neuropsychological variables and (2) a holistic perspective toward understanding these relationships and their relevance to rehabilitation in schizophrenia.

Activities of Daily Living↗
PubMed1997

Abnormal orienting in schizotypal personality disorder.

Previous studies have found evidence for skin conductance (SC) orienting abnormalities in psychosis-prone subjects, but there have been no previous studies on subjects with a diagnosis of schizotypal personality disorder. This study assesses whether clinical schizotypal subjects show abnormal habituation to orienting stimuli. Thirteen subjects with both high scores on the Schizotypal Personality Questionnaire (SPQ) and a DSM-III-R clinical diagnosis of schizotypal personality disorder were compared to 30 controls with no such diagnosis and with low scores on the SPQ. While normals showed the expected habituation in SC orienting across trials, schizotypal subjects failed to show a decrement in responding across the first three trials. In a second study on 30 new subjects, individual differences in schizotypy correlated significantly (p = 0.47) and in the predicted direction with a dimensional measure of the orienting deficit. It is hypothesized that this retarded habituation in schizotypals reflects a deficit in preattentive template matching, which may in turn partly relate to the working memory and prefrontal deficits observed in schizotypal and schizophrenia patients.

Adolescent↗
PubMed1997

Childhood behavior precursors of schizotypal personality disorder.

No study has yet reported specifically on the early behavior of individuals later diagnosed with schizotypal personality disorder (SPD). This study examines prospectively collected teacher reports on school behavior as a means of assessing childhood precursors of SPD. Thirty-six DSM-III-R diagnosed schizotypal subjects were compared with four other groups: 31 schizophrenia patients, 37 diagnosed as nonpsychotic mentally ill, 68 who were not mentally ill but had mothers with schizophrenia, and 60 who were not mentally ill and had normal parents. These individuals were compared on a teachers' school report questionnaire obtained when the subjects averaged 15.1 years old. Those who later developed SPD were found to be more passive and unengaged and more hypersensitive to criticisms compared with the nonschizophrenia groups. Similar results were found when males and females were examined separately, except that males who developed SPD were found to be less disruptive and hyperexcitable compared with males with schizophrenia; females with SPD did not differ from females with schizophrenia. A receiver operating characteristic analysis found these factors to predict 73.5 percent of future SPDs; the ability of these factors to predict future SPDs is comparable for males and females. These findings suggest that preschizotypal traits may be identified in late childhood or adolescence.

Adolescent↗
PubMed1996

Autonomic nervous system factors underlying disinhibited, antisocial, and violent behavior. Biosocial perspectives and treatment implications.

This paper reviews the autonomic psychophysiological correlates of antisocial and aggressive behavior in children and adolescents, outlines a biosocial perspective, and draws implications for treatment and prevention. Findings of studies on resting skin conductance and heart rate indicate that antisocial individuals are characterized by underarousal; these findings suggest that aggressive children may be stimulation seekers who are relatively fearless. Autonomic underarousal also typifies infants and young children with a disinhibited temperament that is thought to be a predisposition to juvenile delinquency and adult aggressive behavior. Deficits in the orienting response, a measure of attention allocation, also predisposes to later antisocial and criminal behavior. Initial studies have shown that particularly high levels of orienting, arousal, and conditionability may protect against crime development in those predisposed to such an outcome. From a biosocial standpoint, it is hypothesized that the psychophysiological correlates of antisocial and violent behavior may be greatest in those from more benign home backgrounds where the psychosocial push forward is relatively weaker. Alternatively, early environmental stress may underlie autonomic underarousal and hyporeactivity in antisocial individuals. Finally, it is possible that biofeedback, in combination with a multimodal treatment program, may be one benign intervention technique that may increase arousal and reduce aggression in underaroused antisocial children.

Adult↗
PubMed1996

High rates of violence, crime, academic problems, and behavioral problems in males with both early neuromotor deficits and unstable family environments.

BACKGROUND: It is commonly assumed that individuals with both biological and psychosocial deficits are more likely to become criminal, but there is surprisingly little empirical support for this assumption. We test the hypothesis that a group with biosocial risk factors are more likely to develop behavioral and academic problems in adolescence and violent criminal offending in adult-hood compared with groups with only biological or only social risk factors. METHODS: Hypotheses were tested on a sample of 397 male subjects, using obstetric and early neuromotor measures collected in the first year of life; family, social, demographic, and behavioral measures at age 17 to 19 years; and criminal data at 20 to 22 years of age. RESULTS: Cluster analysis of the risk factors indicated a group with obstetric risk factors only, a group with poverty risk factors only, and a biosocial group with both early neuromotor deficits and unstable family environments. The biosocial group had more than double the adult violence, theft, and total crime rates of the other 2 groups and had significantly more behavioral and academic problems in adolescence. CONCLUSIONS: When early neuromotor deficits and negative family factors cluster together, individuals are particularly likely to become criminal and violent compared with those with only poverty or only obstetric risk factors. Because this biosocial group accounted for 70.2% of all crimes committed in the entire sample, early interventions that tackle these deficits might significantly reduce violence.

Achievement↗
PubMed1995

Cognitive and psychophysiological correlates of positive, negative, and disorganized symptoms in the schizophrenia spectrum.

This study examined the cross-sectional and prospective relationships between cognitive and psychophysiological variables and positive, negative, and disorganized symptoms in 40 outpatients with diagnoses of schizophrenia or schizoaffective disorder. The results indicated that disorganized symptoms were related to deficits in auditory and visuomotor attentional processing, increased skin conductance orienting response, and lower stress reactivity. Negative symptoms were related to reduced resting heart rate, increased stress reactivity, and deficits in visuomotor processing. Prospective findings indicated that both the cognitive and heart-rate variables might be trait-related aspects of the negative symptoms, while the skin conductance, but not the cognitive, variables might be trait-related aspects of the disorganized symptoms. Positive symptoms were not related to any of the cognitive or psychophysiological variables.

Adult↗
PubMed1995

Patterns of cognitive asymmetry and syndromes of schizotypal personality.

The Schizotypal Personality Questionnaire, modeled on the nine components of DSM-III-R schizotypy, was administered to 122 medical students along with the Thayer Activation-Deactivation Adjective Checklist and the Warrington Recognition Memory Test for words and faces. Close affinities were found between a three-factor schizotypal personality structure and a three-syndrome model of schizophrenia. Different patterns of cognitive asymmetry (word-face discrepancy scores) were related to Active and Withdrawn syndromes as in schizophrenia, and were related to high activation and general deactivation differences as predicted. A prospective single case study showed that a face-word discrepancy before a first episode of schizophrenia accurately predicted a Withdrawn presenting syndrome. The consistency between syndromes of schizophrenia and schizotypal personality in a normal population suggests possible etiological links between the two, and it supports a dimensional view of psychosis and subclinical predispositions.

Adult↗
PubMed1995

The stability of inhibited/uninhibited temperament from ages 3 to 11 years in Mauritian children.

Stability of inhibited/uninhibited temperament was assessed using 1,795 Mauritian children tested at ages 3, 8, and 11 years. Children were divided into uninhibited, middle, and inhibited groups at each age based on social behavior. Results indicated that, relative to uninhibited children (1) those inhibited at age 3 obtained larger inhibition scores at age 8 (p < .0001), (2) those inhibited at age 8 obtained larger inhibition scores at age 11 (p < .002), and (3) those remaining inhibited from ages 3 to 8 obtained larger inhibition scores at age 11 (p < .002). Relative to children who changed classification from ages 3 to 8, those remaining inhibited obtained larger inhibition scores (p < .05) and those remaining uninhibited obtained smaller inhibition scores (p < .015) at age 11. Inhibition scores tended to be higher in females by age 11. Results remained regardless of ethnicity. The results provide some support that inhibited/uninhibited temperament remains stable from ages 3 to 8 and may continue to age 11. The results suggest cross-cultural generalizability of these findings with implications regarding the development of anxiety disorders in the Mauritian population.

Anxiety Disorders↗
PubMed1995

P300 topography in Alzheimer's disease.

This study assessed whether P300 scalp topography distinguished subjects with Alzheimer's disease (AD) from controls. Specifically, it was predicted that the AD group would show maximum P300 amplitude over frontal areas and the largest P300 reduction over parietal and left hemisphere areas. These hypotheses were tested using a standard auditory oddball paradigm to compare 26 AD subjects and 26 controls matched on age, sex, handedness, and education. P300 was measured at frontal, central, parietal, and occipital sites over left and right hemispheres and along the midline. Results revealed that the distribution of P300 was different for the two groups such that the controls manifested a maximum over parietal areas, whereas the AD subjects showed a maximum at frontal sites with the largest reductions in P300 over parietal areas. No hemispheric differences in P300 were found. These results are consistent with the hypothesis that P300 represents the activity of multiple neural generators that are differentially disrupted by the disease process.

Adult↗
PubMed1995

High autonomic arousal and electrodermal orienting at age 15 years as protective factors against criminal behavior at age 29 years.

OBJECTIVE: Nothing is known about biological factors that protect a predisposed individual from becoming criminal. This 14-year prospective study tested the hypothesis that antisocial adolescents who desist from crime by age 29 have greater physiological arousal and orienting than antisocial adolescents who become adult criminals. METHOD: Physiological arousal and orienting were measured in 101 unselected 15-year-old male schoolchildren. Of these, 17 antisocial adolescents who desisted from adult crime (desistors) were matched on adolescent antisocial behavior and demographic variables with 17 antisocial adolescents who became criminal by age 29 (criminals), and 17 nonantisocial, noncriminal normal subjects. RESULTS: Desistors had significantly higher electrodermal and cardiovascular arousal and higher electrodermal orienting than the criminal group. CONCLUSIONS: This is the first study to report biological factors that protect against the development of criminal behavior. The findings suggest that individuals predisposed to adult crime by virtue of showing antisocial behavior in adolescence may be protected from committing crime by high levels of autonomic arousal and orienting.

Adolescent↗
PubMed1994

Selective reductions in prefrontal glucose metabolism in murderers.

This study tests the hypothesis that seriously violent offenders pleading not guilty by reason of insanity or incompetent to stand trial are characterized by prefrontal dysfunction. This hypothesis was tested in a group of 22 subjects accused of murder and 22 age-matched and gender-matched controls by measuring local cerebral uptake of glucose using positron emission tomography during the continuous performance task. Murderers had significantly lower glucose metabolism in both lateral and medial prefrontal cortex relative to controls. No group differences were observed for posterior frontal, temporal, and parietal glucose metabolism, indicating regional specificity for the prefrontal deficit. Group differences were not found to be a function of raised levels of left-handedness, schizophrenia, ethnic minority status, head injury, or motivation deficits in the murder group. These preliminary results suggest that deficits localized to the prefrontal cortex may be related to violence in a selected group of offenders, although further studies are needed to establish the generalizability of these findings to violent offenders in the community.

Adult↗
PubMed1994

Birth complications combined with early maternal rejection at age 1 year predispose to violent crime at age 18 years.

BACKGROUND: This study tests the bisocial interaction hypothesis that birth complications when combined with early maternal rejection of the infant predispose to adult violent crime. METHODS: This hypothesis was tested using a cohort of 4269 consecutive live male births on whom measures of birth complications (age 0), early maternal rejection (age 1 year), and violent crime (age 18 years) were collected. RESULTS: A significant interaction (P < .0001) between birth complications and early maternal rejection indicated that those who suffered both birth complications and early child rejection were most likely to become violent offenders in adulthood. While only 4.5% of the subjects had both risk factors, this small group accounted for 18% of all violent crimes. The effect was specific to violence and was not observed for nonviolent criminal offending. CONCLUSIONS: To our knowledge, this is the first study to show that birth complications in combination with early child rejection predispose to violent crime. The findings illustrate the critical importance of integrating biological with social measures to fully understand how violence develops and also suggest that prenatal, perinatal, and early postnatal health care interventions could significantly reduce violence.

Adult↗
PubMed1994

Bilateral electrodermal activity and cerebral mechanisms in syndromes of schizophrenia and the schizotypal personality.

Bilateral electrodermal measurement was among the first to investigate abnormalities of lateralization in schizophrenia, and recent classification of non-institutionalized patients by lateral asymmetry has delineated positive and negative syndromes associated with opposite states of hemispheric balance. The neuropsychology of the symptoms is consistent with higher left- than right-hemispheric activity in the positive syndrome, and higher right- than left-hemispheric activity in the negative syndrome, evidence which in turn is consistent with current theory about hemispheric influences on electrodermal responses. As all patients had Schneiderian symptoms in common this provided a three-syndrome model, a model having affinities with contemporary reports of three-factor solutions in factor analyses of clinical ratings. All approaches describe two positive syndromes and one negative syndrome. The same model applied to the schizotypal personality has produced a three-factor solution having a strong bearing on the three schizophrenia syndromes, together with evidence of imbalances in functional lateralization that are consistent with the schizophrenia model. It is proposed that the controversy surrounding the orienting and habituation anomalies in schizotypal personality, which include reduced activity, augmented activity, and irregular habituation, may be elucidated by examining relationships with the three-syndrome model and through bilateral measurement. However, provision must be made for distinctions between processes of fixed structure and dynamic function, a critical requirement in view of the relations between electrodermal reactivity and orienting to the dynamic processes of arousal, attention and anxiety. The central nervous system underpinnings of electrodermal responsiveness in schizophrenia, notably the responder-non-responder distinction, is beginning to be elucidated through neuropsychological testing and brain imaging techniques. Research is warranted to explore an integration between the syndromes which evolved from bilateral measurement, and the responder-non-responder classification which arose from considerations of limbic dysfunction.

Brain↗
PubMed1994

Cognitive-perceptual, interpersonal, and disorganized features of schizotypal personality.

While two factors are currently thought to underlie individual differences in schizotypal personality, three factors may best explain schizotypal traits. This study used confirmatory factor analysis to assess five competing models of schizotypal personality in the general population: null model, one-factor model, simple two-factor model, Kendler two-factor model, and three-factor model. The computer program LISREL was used to analyze Schizotypal Personality Questionnaire subscale scores that reflect the nine traits of schizotypal personality. The scores were obtained from (1) a sample of 822 undergraduates and (2) a replication sample of 102 subjects drawn from the community. Results indicate replicable support for a three-factor model reflecting cognitive-perceptual, interpersonal, and disorganized latent factors. Low intercorrelations between the first two factors and the lack of fit by a one-factor model are partially inconsistent with recent notions that a single vulnerability dimension underlies schizotypal personality. It is argued that future investigations should assess the correlates of all three schizotypal factors in clinical and nonclinical samples in addition to the two more traditional factors. It is hypothesized that three factors of schizophrenic symptomatology observed in recent studies may reflect an exaggeration of three analogous factors found in the general population.

Adolescent↗
PubMed1994

The relationship of sweat gland count to electrodermal activity.

This study assessed whether greater skin conductance activity at the distal versus medial site (Scerbo, Freedman, Raine, Dawson, & Venables, 1992) is attributable to a greater number of active (open) sweat glands at the distal site. The number of sweat glands was measured using the Palmar Sweat Index (PSI). Twenty-four subjects were exposed to 10 auditory stimuli. Electrodes were placed on the fore and middle fingers of each hand, using distal sites on one hand and medial sites on the other. The PSI was measured at the medial and distal phalanges adjacent to the electrode placement sites. The distal site contained more open and total sweat glands. Open gland count had the strongest correlations with skin conductance. Multivariate analyses of covariance revealed that site effects for nonspecific and orienting response frequency and trials to habituation were associated with site differences in open glands. Skin conductance measures and the PSI reveal greater electrodermal activity at the distal site. In addition, the number of open glands may be a useful measure related to electrodermal response frequency when polygraph measurement is unavailable.

Acoustic Stimulation↗
PubMed1993

Features of borderline personality and violence.

This study tested the hypothesis that borderline personality characterizes extreme violence by assessing features of borderline and schizotypal personality in three groups: Murderers, Violent, and Nonviolent adult offenders. Murderers had higher borderline personality scores than nonviolent offenders (p < .04). A test for linear trend indicated a linear increase in borderline scores with increasing degree of violence across the three groups (p < .02). No group differences were observed for schizotypal personality. Borderline traits associated with extreme violence consisted of unstable, intense relationships and affective instability. Group differences were not an artifact of group differences in age, social class, IQ, or number of previous custodies. It is concluded that borderline personality may predispose toward extreme forms of violence.

Adult↗
PubMed1993

Impaired eye tracking in undergraduates with schizotypal personality disorder.

Qualitative ratings of smooth pursuit eye movements were significantly worse for 14 undergraduates with DSM-III-R schizotypal personality disorder than for 18 comparison subjects. The groups did not differ on IQ, indicating that deficits in smooth pursuit eye movements in schizotypal personality disorder are not a function of cognitive deficits.

Female↗