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Biomedical subjects

A Radu

Publications and source records attributed to A Radu.

At least 55 records · Page 3Linked to original sources
PubMed1977

Myotubular (centronuclear) (neuro-)myopathy. I. Clinical, genetical and morphological studies.

Five new cases of myotubular (centronuclear) (neuro-)myopathy are presented. Myometric studies revealed type I fibre atrophy and mispositioned nuclei, at various stages between the myotubular structure and the normal subsarcolemmic position. Certain morphological changes, for instance target structures, suggest denervation involving the fibres in an early stage of myogenesis; differentiation seems to be more affected than growth. The genetic defect has an autosomal recessive mode of inheritance with penetrance and degree of expressivity varying from one case to another in the three families.

Adult↗
PubMed1975

Duchenne muscular dystrophy and poliomyelitis. A study of dystrophic-denervated muscle.

A systematic study of dystrophy-denervation in human muscle showed minimal morphometabolic differences between dystrophic and dystrophic-denervated muscle. The only certain conclusion is that denervation influences the rhythm of evolution of the dystrophy without impressing any of the few characteristics considered at present as peculiar to denervation.

Child↗
PubMed1970

Calcium uptake and bioelectrical activity of denervated and myotonic muscle.

Calcium uptake on muscle microsomal fraction has been investigated in connection with bioelectrical activity in some muscle diseases. The findings showed a significant increase of calcium uptake in denervated muscle, which exhibited spontaneous bioelectrical activity (fibrillations). In myotonias, a low calcium uptake was peculiar to Steinert's disease but not to myotonia congenita. In other muscle diseases, such as progressive muscular dystrophy (Duchenne's type) or Charcot-Marie-Tooth's disease, the ability of muscle microsomal fraction to bind calcium was not changed. Starting with the key role of calcium in excitation-contraction coupling, the implications of calcium uptake disturbances in muscle electrogenesis are discussed.

Biopsy↗
PubMedDate not supplied

Adenoviral-mediated gene transfer in wound healing: acute inflammatory response in human skin in the SCID mouse model.

The use of an adenoviral vector as a means of therapeutic protein delivery for the treatment of impaired wound healing is a potentially effective application of current gene transfer techniques. This study was designed to investigate the ability of adenovirus to mediate gene transfer in healing wounds in human skin in vivo. The human skin/severe combined immunodeficient mouse chimera model was used to study both the response of human tissue to adenoviral infection and the nature of the acute inflammatory response. The effects of adenoviral infection and transgene expression on the rate and quality of human wound healing were then investigated. Cell- and species-specific monoclonal antibodies were used to characterize the resident skin cell types participating in wound repair, the inflammatory response, and the proliferative potential of adenovirus-treated compared to control skin. Our studies show that, following wounding, normal skin architecture is restored in the presence of adenoviral infection equivalent to noninfected controls. Despite an increased acute inflammatory response after adenovirus injection, no difference in the healing capabilities of wounded skin was observed, suggesting that adenovirus-mediated gene transfer for growth factor-mediated acceleration of wound healing may be feasible.

Adenoviridae Infections↗