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Biomedical subjects

A Racadot

Publications and source records attributed to A Racadot.

At least 73 records · Page 4Linked to original sources
PubMed1983

[Profile of gonadal hormones in 8 cases of male anorexia nervosa studied before and during weight gain].

Hormonal investigations were performed in 8 cases of male anorexia nervosa at the time of their maximum emaciation. In 6 cases, these investigations were repeated during weight gain. At the time of the maximum emaciation, serum testosterone (T) was decreased in every case. Mean values of serum T, estradiol (E2), LH and FSH were significantly lower than those of controls with a comparable age and a normal weight. Four times out of five serum gonadotropins did not increase after LHRH injection. During weight gain, values of T, E2, LH, FSH and the gonadotropins' response to LHRH increased. T values and the corpulence index were significantly correlated (p less than 0,001), though these 2 parameters did not constantly change in a parallel way. Thus, male anorexia nervosa is associated with a severe hypogonadotropic hypogonadism. This hypogonadism results from weight loss, but also from other factors, especially psychosomatic ones.

Adolescent↗
PubMed1982

[Blood prolactin in 845 cases of clinically idiopathic sexual dysfunction].

Serum prolactin levels were measured in 845 subjects presenting with clinically idiopathic sexual dysfunction, including impotence, premature or defective ejaculation and frigidity in women. Stimulation tests using thyrotrophin-releasing hormone (TRH) and sulpiride were performed in 80 men. One p. cent of impotent subjects had high serum prolactin levels associated with pituitary adenoma in 4/5 cases; 2.2% of impotent men, 10% of men with premature ejaculation and 5.6% of frigid women had moderate hyperprolactinaemia (50 ng/ml), probably not responsible for the sexual disorder. Mean serum prolactin levels were slightly below normal values (p less than 0.05) in impotent subjects. The results of stimulation tests were normal in all but one case. The mean area under the TRH response curve was moderately reduced in subject with impotence or defective ejaculation (p less than 0,05). The present study suggests that serum prolactin levels should be systematically measured in subjects with sexual impotence.

Female↗
PubMed1982

[Dopamine-secreting phaeochromocytoma. A little known clinical and biochemical entity (author's transl)].

The authors have observed a case of phaeochromocytoma revealed by fever and poor general condition without hypertension. Urinary catecholamine assays showed predominant dopamine secretion. Only 13 cases of dopamine-secreting phaeochromocytoma have been published so far, including 4 with clinical symptoms resembling those of this patient. The metabolic and hormonal effects of high plasma dopamine levels were studied, and responses similar to those observed with TRH stimulation by dopamine infusions were obtained: TSH and prolactin responses were inhibited, and GH was increased. This case underlines the need for catecholamine assays, including dopamine, in patients with unexplained fever and apparently non-secretory adrenal tumour.

Adrenal Gland Neoplasms↗
PubMed1982

Modification of human transcortin by tetranitromethane. Evidence for the implication of a tyrosine residue in cortisol binding.

The effect of tetranitromethane on the cortisol binding activity of human transcortin has been investigated. This reagent induced a decrease of activity concomitant with nitration of tyrosine residues. An oxidation of sulphydryl groups was also observed but had no implication on cortisol binding. The nitration was specifically oriented in the site at pH6 and with low concentrations of reagent; under these conditions, a single essential tyrosine per molecule of transcortin seems implicated in cortisol binding. The absence of denaturation in modified transcortin was checked by circular dichroism spectra and polyacrylamide gel electrophoresis. Site specificity was demonstrated by full protection with cortisol against inactivation.

Binding Sites↗
PubMed1979

[Application of adsorption chromatography to the colorimetric determination of urinary estrogens in late pregnancy (author's transl)].

A new extraction procedure of urinary estrogens, based upon adsorption chromatography on Amberlite XAD-2, was deviced for a selective and complete extraction of these components. Estrogens were then quantified, without preliminar hydrolysis, by the colorimetric Kober reaction, modified by Ittrich. The reliability of this method has been established by comparison with four other methods.

Adsorption↗
PubMed1978

Changes in pituitary gonadotropins during the amenorrhoea-galactorrhoea syndrome due to sulpiride.

Sulpiride, a dopamine receptor blocker which raises prolactin, was given to six women with idiopathic amenorrhoea for 10 days and to eleven women with regular cycles for 3 to 6 months. The latter group developed galactorrhoea and amenorrhoea during treatment. Basal LH AND FSH concentrations showed no significant changes. At 3 months but not at 10 days (amenorrhoea group) or 6 months (regular menses group) the area-under-the-curve of LH response to LHRH was increased. FSH responses to LHRH was not altered. The significance of these results to the hyperprolactinaemia-amenorrhoea syndromes are discussed.

Amenorrhea↗
PubMed1978

[Serum thyroid hormones in hyperthyroid patients treated with carbimazole (author's transl)].

Serum thyroxine (T4), triiodothyronine (T3) and thyrotropin (T.S.H.) were measured in 32 hyperthyroid patients treated with carbimazole. A discrepancy between serum T4 AND T3 was present in 73 of 131 measurements: --normal T3 with increased T4 in 6 measurements; --increased T3 with normal T4 in 16 measurements: five times only there was a clinical hyperthyroidism; --normal T3 with decreased T4 in 49 measurements: three times only there was a clinical hypothyroidism. Serum T.S.H. level was increased in 13 of 19 measurements made in this group, state named "compensated hypothyroidism" according to Patel and Burger.

Carbimazole↗
PubMed1978

[Phaeochromocytoma with hypokalaemia (two cases) (author's transl)].

Two cases of phaeochromocytoma with hypokalaemia are reported. In the first, a carcinoma, hypokalaemia was potentially secondary to hyperreninaemia and hyperaldosteronism in association with probably paraneoplastic hypercorticism. The other was benign and the origin of isotopically demonstrated potassium deficiency was less clear, because hyperreninaemia, hyperaldosteronism and hypercortisolism were moderate.

Adrenal Gland Neoplasms↗
PubMed1977

[Exchangeable electrolytes, glycoregulation and growth hormone in one case of Bartter's syndrome (author's transl)].

Total body water (T.B.W), extra-cellular fluid volume (E.C.F.), exchangeable sodium (NaE) and potassium (KE) were measured in one typical case of Bartter's syndrome with growth retardation. Intracellular potassium depletion was associated with a slight impaired carbohydrate tolerance and with decreased growth hormone response to arginine infusion and insulin-induced hypoglycemia. These observations demonstrate that impairement of growth hormone responses to stimulation occur in Bartter's syndrome with potassium depletion.

Adult↗
PubMed1976

[Determination of serum transcortin levels by electroimmunodiffusion (author's transl)].

The isolation of transcortin in a pure form made possible the preparation of a monospecific anti-human transcortin rabbit serum. Serum transcortin levels were measured by electroimmunodiffusion. Experimental results expressed as errors by the calculating of interserial reproducibility were 4.74 per 100. The mean value was significantly different for men (36 subjects: 39.7 +/- 3.6 mg/l) from women (36 subjects: 42.1 +/- 3.9 mg/l). The transcortin determination was performed in pregnancy serum and in serum of women during oestroprogestative treatment. Some studies were performed in pathological cases (hyper- and hyperthyroidism, hyper- and hypocorticism, Kahler disease, ascitic cirrhosis).

Adrenal Insufficiency↗