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Biomedical subjects

A Ríos

Publications and source records attributed to A Ríos.

At least 127 records · Page 7Linked to original sources
PubMed1984

Bone marrow histologic pattern--the best single prognostic parameter in chronic lymphocytic leukemia: a multivariate survival analysis of 329 cases.

In previous studies, the prognostic value of bone marrow (BM) histologic patterns in chronic lymphocytic leukemia (CLL) has been demonstrated. In order to investigate whether such a value is independent of other prognostic parameters, a multivariate survival analysis (Cox's regression model) was undertaken in a series of 329 CLL patients in whom a BM had been performed. The following binary variables were included in the analysis: age (more than 60 years), lymphadenopathy (more than two areas involved), splenomegaly, hepatomegaly, absolute lymphocyte count (more than 30,000 microL), anemia (hemoglobin less than 10 g/dL), thrombocytopenia (less than 100,000 microL), and BM pattern (diffuse v nondiffuse). Three variables entered the regression at significant level: BM pattern (P less than .001), anemia (P less than .001), and hepatomegaly (P = .03). The model was also tested by expressing the variables in a continuous way when possible. Again, BM pattern entered first in the regression (P less than .001), followed by the hepatomegaly (P = .002), hemoglobin level (P = .02), and lymphadenopathy (P = .04). When both the binary and the continuous models were tested separately in 227 patients with BM as initial staging procedure and in 102 patients in whom this was performed later during the course of the disease, in all instances, BM pattern entered first in the regression at a highly significant level. BM histologic pattern appears to be a better single prognostic parameter than any one of the variables employed in current clinical staging systems. A combined clinicopathologic system incorporating the BM pattern, together with the usual clinical variables, is presented.

Actuarial Analysis↗
PubMed1982

An electron microscopic study on the muscle cells and nerve fibres in the digestive gland of the snail Cryptomphallus aspersa.

This work is an electron microscopic study of the muscle cells and the nerve fibres which can be found between the connective tissue of the digestive gland of the gastropod mollusc Cryptomphallus aspersa. The muscle cells are smooth and are located immediately below the basal lamina of the secretory epithelium or in more central zones of the connective tissue of the gland. Two types of myofilaments can be found in the sarcoplasm: thin and thick. The thin ones have an approximate diameter of 5 nm, whereas the thick ones vary in diameter between 15 and 65 nm. The possibility exists that the myofilaments of 15 nm might belong to a third type. Nerve fibres can be found in central zones of the connective tissue of the digestive gland, at the base of the glandular tubules and within the secretory epithelium. In these fibres it is characteristic to find a large number of granules, of a diameter between 80 and 250 nm, surrounded by a membrane, the content of which varies in density. Small clear vesicles of 40 . . . 70 nm in diameter can also be observed. Occasionally granules, which fuse their membranes thus mixing their content, can be detected.

Animals↗