Cardiovascular system and kidney as specific targets of chronic exposure to vanadate in the rat: functional and morphological findings.
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Animals↗
Biomedical subjects
A R Volpe
Publications and source records attributed to A R Volpe.
The effect of an anticalculus dentifrice on supragingival calculus formation and gingival recession in Thai adults: a one-year study.
A one-year, double-blind clinical study was conducted on a population of male and female adults to determine the effect of the twice daily use of an anticalculus dentifrice on supragingival calculus formation and gingival recession, as compared to the use of a placebo dentifrice. The subjects were initially evaluated for calculus using the Volpe-Manhold scoring procedure and for gingival recession using the Gingival Recession Total (GRT) scoring procedure of Volpe, Triratana and Rustogi. All subjects received an oral prophylaxis and were assigned to the use of either a placebo dentifrice containing 0.243% sodium fluoride in a silica base or an anticalculus dentifrice containing 1.3% soluble pyrophosphate and 1.5% Gantrez copolymer in a 0.243% sodium fluoride/silica base. After six months, the subjects using the anticalculus dentifrice had 24.14% significantly less supragingival calculus than the placebo dentifrice subjects. After one year, the subjects using the anticalculus dentifrice had 40.76% significantly less supragingival calculus than the placebo dentifrice subjects. Also, after one year, the subjects using the anticalculus dentifrice had 27.75% significantly less gingival recession than the placebo dentifrice subjects.
Adult↗
New perspectives regarding calculus and gingival recession.
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Dental Calculus↗
The effect of an anticalculus dentifrice on calculus formation and gingival recession in Thai children and teenagers: one-year study. Study #1. An anticalculus dentifrice containing 3.3% soluble pyrophosphate and 1.0% of a copolymer.
A one-year, double-blind clinical study was conducted on a population of Thai children and teenagers to determine the effect of the twice daily use of an anticalculus dentifrice on supragingival calculus formation and gingival recession, as compared to the use of a placebo dentifrice and the continuation of customary oral hygiene procedures. The subjects were initially evaluated for calculus using the Volpe-Manhold procedure and for gingival recession using the GRT procedure of Volpe, Triratana, and Rustogi. All subjects received an oral prophylaxis and were assigned to the use of 1) a placebo dentifrice containing 0.243% sodium fluoride in a silica base, 2) an anticalculus dentifrice containing 3.3% soluble pyrophosphate and 1.0% Gantrez copolymer--in a 0.243% sodium fluoride/silica base, or 3) continuation of customary oral hygiene procedures. After one year, the subjects using the anticalculus dentifrice had 37.01% less supragingival calculus and 25.09% less gingival recession than the subjects using the placebo dentifrice. Additionally, after one year, the subjects using the anticalculus dentifrice had 34.86% less supragingival calculus and 29.95% less gingival recession than the subjects who continued their customary oral hygiene procedures. All reductions were statistically significant at the 95% or greater level of confidence.
Adolescent↗
The effect of an anticalculus dentifrice on calculus formation and gingival recession in Thai children and teenagers: one-year study. Study #2. An anticalculus dentifrice containing 1.3% soluble pyrophosphate and 1.5% of a copolymer.
A one-year, double-blind clinical study was conducted on a population of Thai children and teenagers to determine the effect of the twice daily use of an anticalculus dentifrice on supragingival calculus formation and gingival recession, as compared to the use of a placebo dentifrice and the continuation of customary oral hygiene procedures. The subjects were initially evaluated for calculus using the Volpe-Manhold procedure and for gingival recession using the GRT procedure of Volpe, Triratana, and Rustogi. All subjects received an oral prophylaxis and were assigned to the use of the following: (1) a placebo dentifrice containing 0.243% sodium fluoride in a silica base, (2) an anticalculus dentifrice containing 1.3% soluble pyrophosphate and 1.5% Gantrez copolymer in a 0.243% sodium fluoride/silica base, or (3) continuation of customary oral hygiene procedures. After six months, the subjects using the anticalculus dentifrice had 35.93% less supragingival calculus than the placebo dentifrice subjects, and 52.74% less supragingival calculus than the subjects who continued their regular/customary oral hygiene procedures. After one year, the subjects using the anticalculus dentifrice had 39.76% less supragingival calculus and 18.33% less gingival recession than the subjects using the placebo dentifrice. Also, after one year, the subjects using the anticalculus dentifrice had 57.86% less supragingival calculus and 16.55% less gingival recession than the subjects who continued their customary oral hygiene procedures. All reductions were statistically significant at the 99% level of confidence.
Adolescent↗
Development of a system to assess visible and hidden gingival recession.
The accurate assessment of gingival recession is important because of soft tissue deterioration and/or the state of soft tissue health. While recession of the gingival margin is a common and important symptom of periodontal disease, it also refers to the location of the gingiva and not to its condition. Recession can occur at all tooth surfaces. This paper describes a new system designed to measure two parameters of gingival recession. One parameter of recession is visible above the gumline to an observer, while another parameter is hidden by the gingiva itself. Visible recession is the shift of the marginal gingiva to a position apical to the cemento-enamel junction. Hidden recession is obscured by gingiva and can be assessed by measuring from the free gingival margin to the level of epithelial attachment. The system developed here differs from the current indices commonly used for gingival recession, since it combines both the visual portion with the hidden portion of recession for a total score. The assessment method is similar to the calculus scoring procedure of Volpe and Manhold and is called the Gingival Recession Total (GRT) scoring system.
Gingival Recession↗
The association between supragingival [correction of subgingival] calculus deposits and the extent of gingival recession in a sample of Thai children and teenagers.
A survey was performed on a sample of children and teenagers in Thailand. The sample consisted of 260 subjects ages 10-17 years. Assessments of the prevalence and amount of supragingival calculus (Volpe-Manhold) on the facial and lingual surfaces of the six mandibular anterior teeth were recorded. All subjects then received a thorough whole mouth prophylaxis. Two weeks later they were reexamined for gingival recession using the Gingival Recession Total (GRT) scoring system on the same six mandibular anterior teeth. For the analysis, the calculus scores were used to categorize the subjects as having slight, medium, or heavy calculus. Using the GRT scores, the same subjects were then categorized as having mild, moderate or extensive gingival recession. The categories of both calculus level and gingival recession level were statistically assessed using the Chi-square distribution and a significant difference was found indicating that the amount of calculus was related to total gingival recession. Subjects with slight calculus had more mild recession whereas medium or heavy calculus formers had more moderate or extensive total gingival recession scores.
Adolescent↗
Clinical efficacy of an anticalculus fluoride dentifrice containing triclosan and a copolymer: a 6-month study.
A 6-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base, as compared to a placebo dentifrice containing 0.243% sodium fluoride in a silica base. Subjects were initially stratified into two balanced groups based on their Volpe-Manhold calculus index scores that were obtained from a 3-month pre-test period using a placebo dentifrice. All subjects received an oral prophylaxis and were assigned to the use of either the fluoride/triclosan/copolymer dentifrice or the placebo dentifrice. Seventy adult male and female subjects completed the entire 6-month study. The results after 3-months' use of their respective dentifrices indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 26.34% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction in supragingival calculus was significant at the 99% level of confidence. The results after 6 months indicated that the subjects using the fluoride/triclosan/copolymer dentifrice had 36.27% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction was significant at the 99% level of confidence.
Adult↗
The effect of A Triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a six-month clinical study.
A total of 108 adult male and female subjects completed a six-month, double-blind clinical study designed to compare the effect of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer of methoxyethylene and maleic acid (Gantrez copolymer) in a 0.243% sodium fluoride/silica base to a 0.243% sodium fluoride/silica placebo dentifrice on supragingival plaque formation and gingivitis. Subjects were stratified into two balanced groups by their baseline plaque and gingivitis scores. They received an oral prophylaxis and were assigned to use either the triclosan/copolymer dentifrice or the placebo dentifrice for the next six months. After six months, the dentifrice containing triclosan/copolymer provided a 24.93% statistically significant (99% level of confidence) reduction in supragingival plaque, and a 19.72% statistically significant (99% level of confidence) reduction in gingivitis compared to the placebo dentifrice. Twice daily use of a dentifrice containing 0.3% triclosan, 2.0% of a copolymer, and 0.243% sodium fluoride in a silica base, over a six-month period, reduces supragingival plaque formation and gingivitis to a significant degree compared to a sodium fluoride/silica base placebo dentifrice.
Adolescent↗
Hydroxyurea: relationship between toxicity and centrally-induced adrenal activation.
The anticancer drug hydroxyurea (HU) at doses of 300-800 mg/kg/day causes a dramatic lethality (up to 100% after a 5-day treatment) in hypophysectomized as well as in adrenalectomized rats drinking physiological saline + 5% glucose. Mortality in controls was less than 10% over a 5-day period. Adrenal stimulatory or replacement therapies protect pituitary- or adrenal-ablated rats against HU toxicity. They also counteract white blood cell changes induced by the drug. HU (30-800 mg/kg) induces a dose-dependent increase of plasma corticosterone in normal rats after single or repeated treatments that is not observed in hypophysectomized animals. HU also increases plasma levels of epinephrine, although this finding cannot account for the rise in plasma corticosterone; indeed, it is secondary to a strong rise in plasma corticosterone. The stimulation of the hypothalamic-hypophyseal-adrenal axis induced by HU is responsible for the drug-induced adrenocortical activation. This activation appears to be a valuable defence mechanism protecting intact rats against HU lethality, and its failure causes the dramatic HU lethality in pituitary- or adrenal-ablated animals.
Adrenal Glands↗
Clinical study of the anticaries efficacy of three fluoride dentifrices containing anticalculus ingredients: three-year (final) results.
A 3-year double blind clinical trial was conducted to compare the caries inhibition of an A.D.A.-accepted fluoride dentifrice to the caries inhibitions provided by three fluoride dentifrices containing anticalculus agents. All dentifrices used a compatible silicon dioxide abrasive system. The initial mean age of the subjects was 9.9 yrs and they resided in F-deficient (F less than 0.3 ppm) communities on Long Island, NY. Caries activity in all groups was low with the average annual increment being less than one surface. There were no statistically significant differences in any of the dental parameters tested, DMFS, DMFT, and buccolingual, mesiodistal and occlusal surface increments. It was concluded that the presence of anticalculus agents, specifically soluble pyrophosphates, zinc chloride and zinc oxide, do not interfere with the caries inhibition benefits of fluoride in a compatible dentifrice formulation.
Acidulated Phosphate Fluoride↗
Comparative anticalculus effect of dentifrices containing 1.30% soluble pyrophosphate with and without a copolymer.
A six-month, double blind, clinical study was conducted to determine the effect on supragingival calculus formation of a dentifrice containing 1.30% soluble pyrophosphate (from 2.0% tetrasodium pyrophosphate) and 1.50% of a copolymer of methoxyethylene and maleic acid, as compared to a dentifrice containing the same amount of soluble pyrophosphate but without the copolymer. This pyrophosphate/copolymer dentifrice contained the optimal ratio of pyrophosphate anion to copolymer required for obtaining a comparable anticalculus effect to a clinically proven anticalculus dentifrice containing 3.3% soluble pyrophosphate and 1.0% of a copolymer. The optimal pyrophosphate/copolymer ratio was determined by a series of in vitro laboratory and in vivo animal studies. Male and female adult subjects were stratified into three balanced groups according to baseline calculus scores. They received an oral prophylaxis and were assigned to the use of either the dentifrice containing soluble pyrophosphate and the copolymer, or to the dentifrice containing soluble pyrophosphate but without the copolymer, or to a placebo dentifrice that did not contain an anticalculus ingredient. The results of the three-month calculus examination indicated that the dentifrice containing soluble pyrophosphate and the copolymer provided a 33.66% reduction in supragingival calculus formation after an oral prophylaxis as compared to the placebo dentifrice. This reduction was statistically significant at the 99 percent level of confidence. The results of the six-month calculus examination indicated that the dentifrice containing the soluble pyrophosphate and the copolymer provided a 36.10% reduction in supragingival calculus formation after an oral prophylaxis, as compared to the placebo dentifrice. This reduction was also statistically significant at the 99% level of confidence.(ABSTRACT TRUNCATED AT 250 WORDS)
Adult↗
Comparison of the anticalculus effect of two soluble pyrophosphate dentifrices with and without a copolymer.
A two phase, six month, double blind clinical study was conducted to compare the effect on supragingival calculus deposits of a dentifrice containing 1.30% soluble pyrophosphate (from 2.0% tetrasodium pyrophosphate) with and without the presence of 1.50% of a copolymer of methoxyethylene and maleic acid. In Phase I of the study, male and female adult subjects were stratified into two balanced groups according to baseline calculus scores. They received an oral prophylaxis and were assigned to the use of either a dentifrice containing 1.30% soluble pyrophosphate and 1.50% copolymer or to a placebo dentifrice that did not contain the anticalculus ingredients. After three months use of the products, the subjects received a calculus examination. The subjects were then entered into Phase II of the study where they were restratified into two balanced groups. They again received an oral prophylaxis and were assigned to the use of either a dentifrice containing 1.30% soluble pyrophosphate with no copolymer or to a placebo dentifrice. The results from the three month calculus examination indicated that the dentifrice containing soluble pyrophosphate and a copolymer reduced supragingival calculus deposits by 29.54%, as compared to the placebo dentifrice (less than 99% level of confidence). The results from the six month calculus examinations indicated that the dentifrice containing soluble pyrophosphate without the copolymer did not provide a statistically significant reduction in supragingival calculus after an oral prophylaxis. Thus, it is concluded that the presence of the copolymer in the soluble pyrophosphate dentifrice was essential for obtaining a statistically significant anticalculus effect.
Adult↗
Effect of a triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a 7-month clinical study.
A total of 108 adult male and female subjects completed a 7-month, double-blind clinical study designed to compare the effect of a dentifrice containing 0.3% triclosan and 2% of a copolymer of methoxyethylene and maleic acid on plaque formation and gingivitis, as compared to a placebo dentifrice. The subjects were stratified into two balanced groups according to baseline plaque and baseline gingivitis scores. They then received an oral prophylaxis and were assigned to the use of either a placebo dentifrice or the triclosan/copolymer dentifrice for the next 7 months. After this time, the dentifrice containing triclosan/copolymer provided a 58.96% statistically significant (99% level of confidence) reduction in plaque [corrected], as compared to the placebo dentifrice. Further, after 7-months' use, the dentifrice containing triclosan/copolymer also provided a 30.17% statistically significant (99% level of confidence) reduction in gingivitis as compared to the placebo dentifrice. The results after 7 months also indicated that the dentifrice containing triclosan/copolymer provided a 97.74% statistically significant (99% level of confidence) reduction in the supragingival plaque deposits on those tooth surfaces with the greatest amount of plaque formation, when compared to the placebo dentifrice. The dentifrice containing triclosan/copolymer also provided 87.56% less sites with the most severe amount of gingival disease, as compared to the placebo dentifrice. This decrease in diseased gingival sites was statistically significant at the 99% level of confidence. It was concluded that the twice daily use of a dentifrice containing 0.3% triclosan and 2% of a copolymer reduces supragingival plaque deposit formation and gingivitis to a highly significant degree, without any extrinsic stains observed.
Adult↗
Effects of two fluoride dentifrices containing triclosan and a copolymer on calculus formation.
A 12-week, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of two dentifrices containing triclosan (Irgacare MP) and a copolymer of methoxyethylene and maleic acid (Gantrez) as compared to a placebo dentifrice. All 147 adult male and female subjects completed the study. Subjects were stratified into three balanced groups on the basis of their Volpe-Manhold index calculus scores as obtained from a 3-month pre-test period using a placebo dentifrice. After a complete oral prophylaxis, subjects were assigned to the use of either the placebo dentifrice, a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride silica base, or a dentifrice containing 0.3% triclosan and 2.0% of a coplymer in a 0.76% sodium monofluorophosphate alumina base. Subjects, after brushing with their assigned dentifrice and soft-bristled toothbrush for 12 weeks, were evaluated by the examining dentist for supragingival calculus formation using the Volpe-Manhold assessment method. These examinations showed that the dentifrice containing 0.3% triclosan/2.0% copolymer in a 0.243% sodium fluoride silica base reduced supragingival calculus deposits by 23.12% and the dentifrice containing 0.3% triclosan/2.0% copolymer in a 0.76% sodium monofluorophosphate alumina base reduced supragingival calculus deposits by 26.15%. Both of these reductions in supragingival calculus were compared to the placebo dentifrice and were statistically significant at the 99% level of confidence.
Adult↗
Anticalculus effect of a fluoride dentifrice containing triclosan and a copolymer.
A 3-month, double-blind, parallel and unsupervised clinical study was conducted to compare the effects on supragingival calculus formation of a dentifrice containing 0.3% triclosan and 2.0% of a copolymer, as compared to a placebo dentifrice. Subjects were initially stratified into two balanced groups based on their Volpe-Manhold Index calculus scores obtained from a 3-month pre-test period using a placebo dentifrice. All subjects received an oral prophylaxis and were assigned to the use of either a dentifrice containing 0.3% triclosan and 2.0% of a copolymer in a 0.243% sodium fluoride/silica base or a placebo dentifrice containing 0.243% sodium fluoride in a silica base. A total of 79 adult male and female subjects completed the study. The results after 3-months' use of their respective dentifrices indicated that the subjects using the triclosan/copolymer dentifrice had 26.34% less supragingival calculus formation than the subjects using the placebo dentifrice. This reduction in supragingival calculus was significant at greater than 97% level of confidence.
Adult↗
Effect of a mouthrinse containing triclosan and a copolymer on plaque formation in a normal oral hygiene regimen.
A 6-day, double-blind parallel clinical study was conducted to determine the effect on plaque formation of a mouthrinse containing 0.03% [corrected] triclosan (Irgacare MP) and 0.25% of a copolymer of methoxyethylene and maleic acid (Gantrez), as compared to a flavored/colored water placebo mouthrinse. A total of 47 subjects were stratified into two balanced groups using their pre-prophylaxis plaque score. All subjects received a thorough oral prophylaxis at the start of the study. Each group was randomly assigned to the use of either the water placebo mouthrinse or the mouthrinse containing triclosan/copolymer. Subjects rinsed their mouths twice daily (mornings and evenings) for 1 minute with 15 cc of their assigned mouthrinse. Immediately after rinsing, the subjects brushed their teeth for 30 seconds with a commercially available dentifrice containing 0.76% sodium monofluorophosphate in a silica base and a soft-bristled toothbrush. The morning rinsing/brushing procedure was conducted under supervision at the clinical facility. The evening rinsing/brushing procedure was performed at home. After 5 days' use of their assigned mouthrinse, subjects were evaluated by the dental examiner for plaque formation using the modified Quigley-Hein scoring procedure. The results indicated that the triclosan/copolymer mouthrinse provided a 31.03% reduction in plaque formation as compared to the water placebo mouthrinse. This reduction was statistically significant at the 99% level of confidence.
Adult↗
Clinical study of a pre-brush rinse and a triclosan/copolymer mouthrinse: effect on plaque formation.
A 6-day, double-blind parallel clinical study was conducted to determine the effect on plaque formation of a mouthrinse containing 0.03% triclosan (Irgacare MP) and 0.25% of a copolymer of methoxyethylene and maleic acid (Gantrez), as compared to a flavored/colored water placebo mouthrinse and Plax antiplaque pre-brushing dental rinse. A total of 60 subjects were stratified into three balanced groups using their pre-prophylaxis Plaque Index score. All subjects received a thorough oral prophylaxis at the start of the study. Each group was randomly assigned to the use of either the water placebo mouthrinse, the Plax mouthrinse or the mouthrinse containing triclosan/copolymer. Subjects rinsed twice daily (mornings and evenings) for 1 minute with 15 cc of their assigned mouthrinse. Immediately after rinsing, subjects brushed their teeth for 30 seconds with a commercially available dentifrice containing 0.76% sodium monofluorophosphate in a silica base and a soft-bristled toothbrush. The morning rinsing/brushing procedure was performed under the supervision at the clinical facility. The evening rinsing/brushing procedure was conducted at home. After 5 days' use of their assigned mouthrinse, subjects were evaluated by the dental examiner for plaque formation. The results indicated that the triclosan/copolymer mouthrinse, when used as a pre-brush rinse prior to regular toothbrushing, provided statistically significant reductions in supragingival plaque formation, when compared to both a pre-brush water placebo mouthrinse (-39.83%) or Plax antiplaque prebrushing dental rinse (-37.30%).
Adult↗