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Biomedical subjects

A R Sheth

Publications and source records attributed to A R Sheth.

At least 253 records · Page 14Linked to original sources
PubMed1975

Changes in the ratio between serum and "specific" levels of human chorionic gonadotropin in different trimesters of pregnancy.

Sixty-one sera from different trimesters of pregnancy were analyzed by two 125-I-NIH-HCG assay systems, employing anti-intact HCG serum and anti theta-HCG serum, respectively. The ratios of the levels measured in the two assay systems changed with the duration of pregnancy. The ratios during trimesters 1,2, and 3 were 2.94, 1.99, and 2.37, respectively. The cross-reactivity of proteohormones other than HCG was tested in both the assay systems. The two assay systems could be comparable in their high degree of specificity. However, the relative affinities of intact HCG and theta-HCG in the two assay systems were observed to be different. It was suggested that the significant differences in the ratios of the levels measured by the tow assay systems might have been infulenced by the occurrence of theta-HCG in serum and that the levels of the subunit must have changed at different stages of pregnancy.

Animals↗
PubMed1975

Circulating levels of prolactin in human breast cancer.

Serum prolactin concentrations were measured by radioimmunoassays in 98 patients with established carcinoma of breast, 12 patients with cystic mastitis and 10 patients with gynaecomastia and compared with that of age matched normal control women. The serum prolactin levels in the patients with breast cancer, gynaecomastia or cystic mastitis were observed to be similar to that in normal women. It was interesting to note that the levels of prolactin in the luteal phase of the cycle were higher than that in the early follicular phase in normal women.

Adult↗
PubMed1975

Antisera to gonadotrophins and placental function in mice. I. Effect on polyamine content.

The effect of antisera to ovine LH and ovine prolactin was studied on polyamine levels in the mouse placenta. The antisera were administered on Day 11, 12 or 13 of pregnancy and the mice were killed 24 hr later. The polyamines (spermine, spermidine and putrescine) in the placentae were estimated. Polyamine levels were reduced after treatment with anti-LH on any of the 3 days and after treatment with anti-prolactin serum on Days 11 or 12. Only the spermidine content was reduced when anti-prolactin serum was injected on Day 13 of pregnancy. Placental DNA and RNA levels paralleled those observed for polyamine content. The changes in polyamine content and nucleic acid levels indicate that these antisera to LH and prolactin interfere with placental function.

Animals↗