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Biomedical subjects

A R Mohammad

Publications and source records attributed to A R Mohammad.

35 records · Page 2Linked to original sources
PubMed1978

Cytotoxicity evaluation of root canal sealers by the tissue culture--agar overlay technique.

Ten commercially available root canal sealers were tested for cytotoxicity by the tissue culture--agar overlay method for periods of 0, 24, 48, 72, and 96 hours. All sealers manifested evidence of toxicity at every stage of testing. Some sealers which were markedly toxic at 0 hour showed reducing levels of toxicity out to 96 hours. Others remained highly toxic throughout the entirety of the experimental period.

Agar↗
PubMed1976

Changes in granular endoplasmic reticulum induced in cultured human monocytes by colony stimulating factor.

The supernatant portion of cultured human monocytes produces a biological factor known as colony stimulating factor. The addition of culture fluid containing colony stimulating factor to cultured human monocytes produced morphologic changes in the granular endoplasmic reticulum. Granular endoplasmic reticulum changed its appearance from long slender cisternae to a concentric pattern (whorls) averaging seven rows per structure 120 min following the addition of culture fluids containing colony stimulating factor.

Cells, Cultured↗
PubMed1976

Dinitrochlorobenzene contact hypersensitivity in the hamster cheek pouch.

Stimulation of cell mediated immunity has been reported to be effective in bringing about clinical regression of carcinomas. The purpose of this pilot study was to investigate the possibility of introducing cell mediated immunity into an experimental animal-chemical carcinogenesis system (dimethylbenzanthracene-hamster cheek pouch) to serve as a model for the study of immunotherapy of oral cancer in humans. Contact hypersensitivity to dinitrochlorobenzene (DNCB) was induced in 17 Syrian hamsters via the abdominal skin. After secondary application of the allergen to the cheek pouch, local gross and histologic characteristics indicative of delayed hypersensitivity were observed. Control animals that had received only a primary or a secondary challenge with DNCB essentially showed no change. This study demonstrates that the buccal pouch of the Syrian hamster is capable of manifesting contact hypersensitivity to DNCB.

Animals↗
PubMedDate not supplied

A pilot study of panoramic film density at selected sites in the mandible to predict osteoporosis.

Osteoporosis is the most common metabolic disease and presents a major public health problem among the elderly. This retrospective pilot study was designed to determine the strength of association of spinal bone density and the density of selected mandibular sites as determined from panoramic radiographs. Panoramic films of known low bone density and high bone density women between the ages of 50 and 75 were evaluated. These films were randomized and then converted to digital images for density analysis. Significant differences were noted between the groups at the 95th percentile. Further study is needed to ascertain the value of panoramic radiology as an adjunct diagnostic tool in the screening of patients thought to be at high risk of developing osteoporosis.

Aged↗
PubMedDate not supplied

The strength of association between systemic postmenopausal osteoporosis and periodontal disease.

This cross-sectional study examined the strength of association between systemic osteoporosis and periodontal status in postmenopausal non-Hispanic white women. Twenty subjects with low bone density and a spine bone density of 0.753 +/- 0.039 dual-energy x-ray absorptiometry units (g/cm2) and 22 subjects with high bone density and a spine bone density of 1.032 +/- 0.028 dual-energy x-ray absorptiometry units (g/cm2) were randomly selected from a cohort of 565 women. Periodontal assessment included Plaque Index, Gingival Index, pocket depth, gingival recession, and periodontal attachment level. There were no significant differences in Plaque Index, Gingival Index, and probing depth in both groups; however, there were significant differences in gingival recession components of periodontal attachment level in both groups. This study suggests that systemic osteoporosis may contribute to periodontal attachment loss in the form of gingival recession.

Aged↗
PubMedDate not supplied

Spinal bone density and tooth loss in a cohort of postmenopausal women.

Osteoporosis has been suggested to contribute to the edentulous condition. However, studies specifically designed to examine the relationship between tooth loss and osteoporosis are scarce, and reported results have been mixed. This study investigated the correlation between tooth loss and spinal bone density in a nonHispanic white female population. Forty-four subjects were recruited and divided into high and low spinal bone density groups based on whether the bone density was higher or lower than the age-adjusted population mean bone density. Missing teeth and periodontal status in these groups were assessed and analyzed. Tooth loss was not significantly different between subjects with low spinal bone density (4.90 +/- 0.89 teeth) and high spinal bone density (3.81 +/- 0.90 teeth). Tooth loss did not differ after age and periodontal adjustment. However, the loss of attachment levels (relative to the cementoenamel junction) was greater in the low spinal bone density subjects (3.42 +/- 0.30 mm) than in the high spinal bone density subjects (2.37 +/- 0.26 mm) (P < .05). The difference may have resulted from gingival recession (P < .05), because the gingival pocket depths were not significantly different between the two groups. In this study, total tooth loss was not directly associated with systemic bone density. However, periodontal disease was negatively associated with spinal bone density. Whether periodontal disease will ultimately lead to greater tooth loss in low spinal bone density group merits further investigation.

Aged↗