URINARY EXCRETION OF 5-HYDROXYINDOLEACETIC ACID (5-HIAA) IN OVULATORY AND ANOVULATORY CYCLES.
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Female↗
Biomedical subjects
A R Fuchs
Publications and source records attributed to A R Fuchs.
Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy.
The purpose of this study was to determine the specificity and concentration of oxytocin (OT) and arginine vasopressin (AVP) binding sites in non-pregnant (NP) human and rhesus monkey endometrium, myometrium and fibromyomas, and to determine the cellular localization of OT receptor (OTR). Besides [3H]AVP, [125I]LVA, a specific VP1 receptor subtype antagonist, was used to determine vasopressin receptor (VPR) concentrations. Samples were obtained from 42 pre-menopausal and three pregnant women (5, 13 and 35 weeks gestation), and several NP and pregnant monkeys. Specificity of binding was assessed in competition experiments with unlabelled agonists and antagonists of known pharmacological potency. Cellular localization of OTR was determined by immunohistochemistry. In NP human uterine tissues, [3H]AVP was bound with higher affinity and greater binding capacity than [3H]OT, whereas in pregnant women and in NP and pregnant rhesus monkeys, uterine OT binding capacity was greater. OT and AVP binding sites discriminated very poorly between OT and AVP; [125I]LVA binding sites were more selective than [3H]AVP. Their ligand specificity and binding kinetics indicated the presence of two distinct populations of binding sites for OT and AVP in primate uterus. Endometrium of NP women and monkeys had low OTR and VPR concentrations. Myometrial and endometrial OTR and VPR were down-regulated in midcycle and in early human pregnancy, they were up-regulated in the secretory phase and second half of pregnancy. Immunoreactive OTR in NP uterus was localized in patches of myometrial muscle cells and small numbers of endometrial epithelial cells.
Adult↗
[The influence of oxytocin on the production of prostaglandins in vitro and in vivo].
In order to test the hypothesis that oxytocin not only leads to myometrial contractions but also to an increase of prostaglandin synthesis in decidua, human decidua, myometrium and amnion were incubated with and without oxytocin in a modified Krebs-bicarbonate-solution. The addition of oxytocin led to a significant increase of PG E- and PG F-synthesis in decidua and to a significant increase in PG-synthesis in amnion. In 15 women in whom labor was induced by intravenous infusion of oxytocin PGFM concentrations were measured before and during induction. PGFM levels rose in all women in whom induction was successful, whereas they stayed unchanged in those women in whom induction failed. These results support the hypothesis that oxytocin leads to an increase in prostaglandin production through specific receptors in decidua.
Amnion↗