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Biomedical subjects

A Prost

Publications and source records attributed to A Prost.

At least 145 records · Page 8Linked to original sources
PubMed1969

Diarrhoea associated with medullary carcinoma of the thyroid.

Diarrhoea, which is present in roughly one third of cases of medullary carcinoma of the thyroid, was investigated in five cases. Excessive loss of water and electrolytes in the stools was the major factor. Steatorrhoea was mild or absent, and intestinal absorption of glucose and vitamin B(12) was normal; the histological appearance of the small intestinal mucosa was normal or subnormal. Water and sodium diarrhoea seems to be linked to a sometimes considerable increase in the rate of transit through the small intestine and colon, and may be relieved by codeine or codethyline. The frequent increase in the maximum blood sugar level during an oral tolerance test should not be interpreted as evidence of a paradiabetic condition. In fact, the intravenous glucose tolerance test is usually normal and the excessive rise in blood sugar after oral administration seems to be the consequence of the increased rate of transit through the small intestine. The link between the tumour and the disordered motility seems definite in view of certain cases in which removal of the tumour caused the diarrhoea to disappear immediately. Production by the tumour of serotonin or other derivatives of tryptophan or of kallikrein, which activates bradykinin, is rare. With regard to prostaglandins, high concentrations have been observed in the tumours and in the venous blood draining the tumours, but their presence in systemic blood is inconstant. The only hormonal substance, concentration of which seems to be definitely increased in the systemic blood of patients with a medullary carcinoma of the thyroid, is thyrocalcitonin but this hormone does not seem to have any effect on the motor activity of the digestive tract.

Adolescent↗
PubMedDate not supplied

[Awareness of 125 patients of the rules for using their non-steroidal anti-inflammatory agent].

A total of 125 inpatients from a rheumatology unit were interviewed to assess their awareness of the rules for using a prescribed NSAID. Two per cent were unaware that they were receiving an NSAID, and 13 per cent and 71 per cent respectively did not know the name or the dosage. Twenty-two per cent admitted excessive intake, and 2 per cent simultaneous intake of two NSAIDs. Some declared that in the absence of adequate improvement they would take another NSAID (17 per cent) or aspirin (26 per cent) simultaneously. Fifty-nine per cent were unaware that aspirin is an anti-inflammatory drug, 3 per cent thought that taking a double dosage on alternate days was safe, and 46 per cent that taking a stronger dose at the beginning of treatment was an efficient and safe procedure. The replies of patients who had read the directions for use (69 per cent) did not differ from those of patients who had not (31 per cent). Fourteen per cent of patients declared that they would not advise their physicians after buying NSAIDs over the counter.

Adult↗
PubMedDate not supplied

[The first case of distomatosis in Upper Volta].

Distomatosis was not reported in Upper-Volta before this first case described in Bobo-Dioulasso. However this disease becomes more frequent in West Africa. Exact parasitologic diagnosis was impossible between Paragonimus and Poïchilorchis congolensis with the clinical, anatomical data of this first observation.

Adolescent↗
PubMedDate not supplied

[Paget's disease and metastatic epithelioma on the same bone. 11 new cases and review of the literature].

The authors collected observations concerning 11 newly histologically proved cases of a combination of Paget's disease and carcinoma metastatic to bone on the same bone from members of the French Rheumatology Society. The most frequent locations can be specified from their analysis and an analysis of 26 detailed cases from the literature, i.e. pelvis, femur, rachis, tibia, humerus, and the cancers most frequently involved--prostate, bronchi, kidney, breast and intestine. The most usual histological appearance is osteolytic, except in the case of prostatic carcinoma. The metastasis reveals the presence of cancer in 2 cases out of 3, whereas Paget's disease is most often already diagnosed. A histological examination is necessary because of the risk of non recognition of such metastases or of confusion with sarcomatous degeneration. It does not appear to be exceptional to find Paget's disease in combination with a metastasis on the same bone. Although six of the cases concern metastases only located at sites of Paget's disease, an analysis of all the cases does not seem to indicate that Paget bone is more exposed to metastases than normal bone, since both diseases in fact locate preferentially at the same sites on the skeleton.

Aged↗