Search PubMed⌕ Search

Biomedical subjects

A Prost

Publications and source records attributed to A Prost.

At least 55 records · Page 3Linked to original sources
PubMed1994

[Intestinal parasitic diseases and environment in Sahelo-Sudanese towns: the case of Pikine (Senegal)].

A survey carried out in Pikine (Senegal) on a sample of 5 groups of children drawn from ecologically representative sections of the town confirms the high prevalence in urban areas of Africa of intestinal infection, especially A. lumbricoides (35.6%), T. trichiura (35.4%), and Giardia (43.7%). The prevalence of A. lumbricoides (35.6%), T. trichiura (35.4%), and Giardia (43.7%). The prevalence of A. lumbricoides and T. trichiura are appreciably higher in the oldest sectors of the town or in those with a better sanitary standard: up to 47.7% for Ascaris and 46% for Trichuris. The use of X2 tests and log-linear analysis demonstrates a significant association between Ascaris and Trichuris. The highest prevalence for Giardia (56.8%) were to be found on the outskirts of the town, where the lowest prevalence of Ascaris (21.7%) and Trichuris (22.9%) were noted; moreover, age-based prevalence for the three parasites vary from one ecological area to another. The relationship between the urbanization process, the variation in environmental factors and intestinal parasitic infection, and the operational implications arising from this geographically-based approach are discussed.

Animals↗
PubMed1993

[Major hypercalcemia disclosing sarcoidosis].

Sarcoidosis is exceptionally revealed by major isolated hypercalcemia. To the 4 cases already published, we are adding this one. A review of the literature is presented, focussed on the frequency and characteristic features of the hypercalcemia associated with sarcoidosis, as well as its physiopathology: an overproduction by granulomatous cells of 1-25 dihydroxyvitamin D3 evading the usual regulatory mechanisms. Treatment rests on corticosteroid therapy and sometimes hydroxychloroquine.

Calcitriol↗
PubMed1993

["Medicolegal" bone fluorosis. Apropos of 2 cases of possible criminal poisoning].

We report two cases of skeletal fluorosis in two men, 55 and 69 year-old. The physical findings and the roentgenograms were typical and chemical analysis confirmed the diagnosis. Surprisingly, fluoride concentrations in blood and urine were increased at the beginning of the hospitalizations and lower during the hospitalizations. The origin of fluor intake remained unknown, leading to consider a possible criminal poisoning. Then, we discuss the attitude of physician in a case a possible criminal poisoning: denunce the crime to the police or not, as regards french law.

Acute Disease↗
PubMed1993

[Extramedullary hematopoiesis. An unusual cause of Pagetic spinal cord compression].

An original case is reported: spinal cord compression due to extramedullary hematopoiesis of the epidural space, related to Paget's disease of bone, successfully treated by surgery. Extramedullary hematopoiesis, usually occurring in cases of hematological disease, can also complicate Paget's disease, probably by bone effraction mechanism. A review of literature has found 5 other cases of extramedullary hematopoiesis occurring in Paget's disease, without hematological disease. Medullar scintigraphy (Indium111, Technetium99 Sulfur colloid) can confirm the diagnosis after X-ray findings, without the need for biopsy. Awareness knowledge of this complication can sometimes avoid invasive investigation. Low dose radiotherapy is useful in the case of hematological disorders. In Paget's disease, there is a risk of sarcomatous degeneration. In our patient, surgery cured cord compression, but it relapsed because of extensive fibrosis, in complicating surgical hemorrhage.

Aged↗
PubMed1992

Corticosteroid injection of the sacroiliac joint in patients with seronegative spondylarthropathy.

OBJECTIVE: We report our experience with the use of corticosteroid injections into the sacroiliac joint in the treatment of patients with seronegative spondylarthropathy. METHODS: We performed 42 injections, constituting 24 procedures in 22 patients (2 patients had the procedure performed twice). RESULTS: The response was considered very good or good in 19 of 24 procedures (79.2%) and 34 of 42 joints (81%). Improvement persisted in 14 patients after a mean +/- SD followup time of 9.6 +/- 4.2 months. CONCLUSION: This technique appears to be safe, easy to apply into ambulatory patients, and quite effective.

Adolescent↗
PubMed1991

[Parosteal sarcoma of the radius in the course of etretinate therapy].

A parosteal osteosarcoma of the right radius has developed in a patient treated for a long time by etretinate (total dose: 73 g). If brachial ossifications have been reported to etretinate in 2 cases, they were benign tumours; so coincidence is possible in our case. Nevertheless, a relation between the tumour and the treatment cannot be excluded and justify the report of this observation.

Bone Neoplasms↗
PubMed1990

Beta-adrenoceptor blockade potentiates exercise-induced release of atrial natriuretic peptide.

The effect of a non selective and a cardio-selective beta-blocker on basal and exercise-stimulated plasma atrial natriuretic peptide concentrations in healthy volunteers has been studied. Nine healthy volunteers received single oral doses of 5 mg tertatolol, 100 mg atenolol or placebo, at one week intervals, in a double blind cross over trial. At rest plasma atrial natriuretic peptide, aldosterone, antidiuretic hormone and cyclic GMP concentrations and plasma renin activity were not modified by the treatments. During exercise plasma atrial natriuretic peptide concentrations were significantly increased by each treatment, the increment being significantly greater on beta-blockers than on placebo. The rise in atrial natriuretic peptide was 72% after placebo (from 24 to 42 pg/ml), 184% after atenolol (from 30 to 86 pg/ml), and 183% after tertatolol (from 34 to 95 pg/ml), respectively. Thus, the study has shown that in healthy subjects the plasma natriuretic peptide concentration is increased by exercise and that the increase is considerably and equally potentiated by selective and non selective beta-adrenoceptor blockade. The effect may be mainly due to a reduction in ventricular contractility with an increase in atrial pressure. The beta-blockers did not influence the resting plasma atrial natriuretic peptide levels, which suggests that in healthy subjects basal atrial natriuretic peptide secretion is not controlled via beta-receptors.

Adrenergic beta-Antagonists↗
PubMed1989

Water, trachoma and conjunctivitis.

The incidence of eye infections in a community is generally accepted as an indicator of the adequacy of water supply for their needs. However, discrepancies in the published results from various studies seem to challenge this view. We have reanalysed the published data on trachoma in relation to the most relevant indicators of water accessibility, using prevalence ratios as the single parameter for risk assessment. A definite trend emerges from this review: the incidence of infectious conjunctivitis is not sensitive to differences in water accessibility; on the other hand, a reduction in the risk of trachoma is consistently associated with better access to water. This conclusion may support the efforts of WHO and other multilateral and bilateral agencies to sustain the commitment towards the water supply sector beyond the International Drinking Water Supply and Sanitation Decade.

Climate↗
PubMed1988

Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis.

The risk-benefit ratio of combined fluoride-calcium therapy in primary vertebral osteoporosis was examined prospectively in patients with at least one vertebral fracture. 257 patients were randomised to receive sodium fluoride 25 mg twice daily plus elemental calcium 1 g daily and a vitamin D2 supplement, and 209 received one of the alternative therapies usually prescribed in France. After a follow-up of 24 months the fluoride-calcium group showed a significantly lower rate of new vertebral fractures, the main adverse effect of the regimen being a higher incidence of osteoarticular pains in the ankle and foot; the risk of non-vertebral fractures was not increased, and digestive disorders arose with equal frequency in the two groups. Sodium fluoride 50 mg daily seems to represent a reasonable compromise in terms of anti-fracture effectiveness and side-effects.

Administration, Oral↗
PubMed1988

[Tiopronin in 69 cases of rheumatoid polyarthritis treated earlier with D-penicillamine].

This study concerns 69 patients with rheumatoid arthritis (RA) and having received successively D-penicillamine (DP) then, after a mean period of 2 years, tiopronin (TP) at a daily dose of 1,500 mg. TP demonstrated an as frequent, as marked, and as prolonged effectiveness as that of DP. 28 patients are still under TP treatment, with a mean length of treatment of 43.7 months. The rate of effectiveness of TP was similar, whether or not the response to DP was favorable: 64.1 and 64.3 p. cent respectively; 72.4 p. cent of the 29 cases which did not respond to DP, responded favorably to TP. The manifestations of intolerance to TP were similar in nature (including the first reported case of obstructive bronchiolitis) and frequency to those observed with DP. There were only a few manifestations of crossed intolerance: the rate of TP discontinuation because of intolerance was the same, whether the DP was well tolerated (29.6%) or discontinued because of poor tolerance (30%). The same undesirable effect was only observed in 4 cases: one case of pemphigus, another case of toxic dermatitis, 2 proteinurias. This study confirms that TP represents a new, major long-term treatment of RA and demonstrates that this very product is an excellent take over medication.

Adult↗