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Biomedical subjects

A Prinz

Publications and source records attributed to A Prinz.

20 records · Page 2Linked to original sources

[Parasitological results of a medico-anthropological research-work at the Azande in northeast-Zaire (author's transl)].

Among 165 examined Azande 118 (71.5%) were found with intestinal helminthic infections: Hookworm (69.1%), Schistosoma mansoni (13.9%), Trichuris trichiura (4.2%), Ascaris lumbricoides (1.2%), Strongyloides stercoralis (0.6%). The intradermal Schistosoma test with a commercial antigen preparation was positive in 63.3% of 147 examinees. Protozoa-excretions were found in 62.2% of 151 examines: E. histolytica (27.2%), E. hartmanni (13.2%), E. coli (24.5%), Jodamoeba buetschlii (7.3%), Endolimax nana (1.3%), Lamblia intestinalis (17.2%). Microfilariae were found in 87 of 165 blood-smears (52.7%). The positive diagnoses increased with the age of the examinees. 73.8% of 141 examinees showed an increase of eosinophilic granulozytes up to 11-29%, and 7.8% up to more than 30%. The reliability of the methods used to conserve the test material under extreme conditions as well as the connection between ethnographical situations and the detected parasites are discussed.

Adolescent↗

Sec61p is the main ribosome receptor in the endoplasmic reticulum of Saccharomyces cerevisiae.

A characteristic feature of the co-translational protein translocation into the endoplasmic reticulum (ER) is the tight association of the translating ribosomes with the translocation sites in the membrane. Biochemical analyses identified the Sec61 complex as the main ribosome receptor in the ER of mammalian cells. Similar experiments using purified homologues from the yeast Saccharomyces cerevisiae, the Sec61p complex and the Ssh1p complex, respectively, demonstrated that they bind ribosomes with an affinity similar to that of the mammalian Sec61 complex. However, these studies did not exclude the presence of other proteins that may form abundant ribosome binding sites in the yeast ER. We now show here that similar to the situation found in mammals in the yeast Saccharomyces cerevisiae the two Sec61-homologues Sec61p and Ssh1p are essential for the formation of high-affinity ribosome binding sites in the ER membrane. The number of binding sites formed by Ssh1p under standard growth conditions is at least 4 times less than those formed by Sec61p.

Endoplasmic Reticulum↗