Biomedical subjects

A Prados

Publications and source records attributed to A Prados.

15 recordsLinked to original sources

PubMed2005

Angiogenic capacity of human omental stem cells.

OBJECTIVES: The goals of the present study are to obtain, expand and characterize a stem cell population from human omentum and to evaluate its in vivo angiogenic capacities. METHODS: Human omental CD34+ cells were obtained from samples of human omentum by density gradient centrifugation in Ficoll. Proliferative pattern, marker expression (by flow cytometry) and angiogenic growth factor synthesis by omental cell cultures were determined. In vivo angiogenic capacity of the cells was evaluated in rats. RESULTS: Omental stem cells showed a high rate of proliferation (Ki67 staining), expressed CD34 marker and synthesized bFGF and VEGF. When implanted in rats, omental cells promoted neovascularization. Human omental cells were localized in rat tissue, mainly forming the endothelium of neo-vessels. Implantation of omental cells also facilitated angiogenesis of rat origin. CONCLUSION: CD34+ cell population of human omentum could be responsible for the clinical benefit of omental transplantation by promoting angiogenesis and synthesizing angiogenic growth factors to facilitate revascularization of injured tissue.

Animals↗

PubMed2003

Closed model for granular compaction under weak tapping.

A one-dimensional lattice model is formulated to study tapping dynamics and the long time steady distribution in granular media. The dynamics conserves the number of particles in the system, and density changes are associated with the creation and destruction of empty sites. The model is shown to be consistent with Edwards' thermodynamics theory of powders. The relationship with lattice models in which the number of particles is not conserved is discussed.

Journal Article↗

PubMed2002

Effective dynamics and steady state of an Ising model submitted to tapping processes.

A one-dimensional Ising model with nearest neighbor interactions is applied to study compaction processes in granular media. An equivalent particle-hole picture is introduced, with the holes being associated to the domain walls of the Ising model. Trying to mimic the experiments, a series of taps separated by large enough waiting times, for which the system freely relaxes, is considered. The free relaxation of the system corresponds to a T=0 dynamics which can be analytically solved. There is an extensive number of metastable states, characterized by all the holes being isolated. In the limit of weak tapping, an effective dynamics connecting the metastable states is obtained. The steady state of this dynamics is analyzed, and the probability distribution function is shown to have the canonical form. Then, the stationary state is described by Edwards thermodynamic granular theory. Spatial correlation functions in the steady state are also studied.

Journal Article↗

PubMed2001

Glasslike dynamical behavior in hierarchical models submitted to continuous cooling and heating processes.

The dynamical behavior of a kind of models with hierarchically constrained dynamics is investigated. The models exhibit many properties resembling real structural glasses. In particular, we focus on the study of time-dependent temperature processes. In cooling processes, a phenomenon analogous to the laboratory glass transition appears. The residual properties are analytically evaluated, and the concept of fictive temperature is discussed on a physical basis. The evolution of the system in heating processes is governed by the existence of a normal solution of the evolution equations, which is approached by all the other solutions. This trend of the system is directly related to the glassy hysteresis effects shown by these systems. The existence of the normal solution is not restricted to the linear regime around equilibrium, but it is defined for any arbitrary, far-from-equilibrium, situation.

Journal Article↗

PubMed2001

Linear response of vibrated granular systems to sudden changes in the vibration intensity.

The short-term memory effects recently observed in vibration-induced compaction of granular materials are studied. It is shown that they can be explained by means of quite plausible hypothesis about the mesoscopic description of the evolution of the system. The existence of a critical time separating regimes of "anomalous" and "normal" responses is predicted. A simple model fitting into the general framework is analyzed in the detail. The relationship between this paper and previous studies is discussed.

Journal Article↗

PubMed2001

Slow logarithmic relaxation in models with hierarchically constrained dynamics.

A general kind of model with hierarchically constrained dynamics is shown to exhibit logarithmic anomalous relaxation similar to a variety of complex strongly interacting materials. The logarithmic behavior describes most of the decay of the response function.

Journal Article↗

PubMed1999

Simple model with facilitated dynamics for granular compaction.

A simple lattice model is used to study compaction in granular media. As in real experiments, we consider a series of taps separated by large enough waiting times. The relaxation of the density exhibits the characteristic inverse logarithmic law. Moreover, we have been able to identify analytically the relevant time scale, leading to a relaxation law independent of the specific values of the parameters. Also, an expression for the asymptotic density reached in the compaction process has been derived. The theoretical predictions agree fairly well with the results from the Monte Carlo simulation.

Journal Article↗

PubMed1996