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Biomedical subjects

A Pradalier

Publications and source records attributed to A Pradalier.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

[Endocrine polyadenomatosis with carcinoid tumor].

The authors review 26 cases of multiple endocrine tumours with presence of a carcinoid tumour. In 44% the carcinoid was localised to the bronchus, in 20% of cases to the small intestine or duodenum. In 76% of cases during multiple endocrine tumours, the carcinoid appeared in embryological derivatives of the anterior part of the intestine. No carcinoid syndrome was reported. The difficulty of histological distinction has led to the description of carcinoid islet cell tumours. These facts fit in with the APUD concept.

Adenoma, Islet Cell↗
PubMedDate not supplied

[Changes in Achilles tendon reflex under influence of non endocrine factors].

Numerous physiopathological processes such as diurnal variations sex, age, pregnancy, muscular effort, diseases and drugs modify the Achilles reflexogram. Their multiplicity explains the difficulty of general interpretation of changes in the reflexogram which bring into play the energy reserves of the muscle cell and its potassium content.

Achilles Tendon↗
PubMedDate not supplied

[Beta-blockers and migraine. Efficacy of time-release propranolol versus placebo].

The efficacy and safety of long-acting propranolol (LA.P) 160 mg once-daily in the prophylactic treatment of migraine were tested against placebo in a multicentric, double-blind, randomized study comparing the two groups in a parallel manner over a treatment period of 12 weeks, and following a 4 week-placebo run-in period. Fifty-five out of the 74 patients who entered the trial included at the end of the run-in period. Forty-one patients completed the study. Out of the 14 patients who withdrew from the study, none discontinued because of side-effects. The statistical analysis was done according to the "intention to treat" principle. LA.P was significantly more efficient than placebo in reducing the frequency of migraine attacks (p = 0.01 by variance analysis). LA.P reduced the average number of monthly crises by 48% on day 84. There was a slight but significant reduction of the systolic blood pressure and heart rate in the erect position. There was no significant difference between LA.P and placebo regarding either the number of complaints or the number of side-effects elicited out of an 17 item questionnaire. None of the observed side effects led to a withdrawal of treatment.

Adult↗
PubMedDate not supplied

[Platelet release of dopamine in the common migraine attack].

Several arguments suggest that dopamine (DA) plays a role in the physiopathology of migraine. Conjugated and unconjugated plasma and platelet DA, as well as platelet phenolsulfotransferase M activity (responsible for DA sulfatation) were measured in 30 control subjects, 27 common migraine patients between attacks and 9 migraineurs during an attack. No modification of any of the parameters tested was detected in attack-free periods. During the attack no change of conjugated DA was observed; in contrast, a significant decrease of unconjugated platelet DA and a significant and correlated increase of plasma unconjugated DA were demonstrated. This corresponds to a release of unconjugated DA by the very dense bodies in platelets of migraine patients during the attack.

Adolescent↗