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Biomedical subjects

A Pouplard

Publications and source records attributed to A Pouplard.

33 records · Page 2Linked to original sources
PubMed1980

[Pituitary insufficiency and auto-immunity (author's transl)].

An indirect immunofluorescence study of the serum of 37 patients with anterior pituitary disease suggested that in a number of them an auto-immune process intervened in the pathogenesis of the condition. Seven sera reacted positively to human pituitary gland and 15 to rat pituitary gland. Auto-antibodies directed specifically against one or several types of pituitary cells seem to be more frequent in pituitary insufficiencies involving one or two hormones. These are more readily detectable when rat pituitary glands are used, and only by this technique can auto-antibodies directed against ACTH-secreting cells be detected.

Animals↗
PubMed1980

Bone tissue in Paget's disease of bone. Ultrastructure and Immunocytology.

Ultrastructural observation in Paget's disease of bone clarify aspects of bone cells in bone tissue and demonstrate the presence of specific intranuclear inclusions composed of microcylinders in the osteoclasts. The morphologic analysis of these structures suggests an analogy with virus material of the measles group. Results obtained using indirect immunofluorescence and immunoperoxidase techniques lend further support to the hypothesis of a viral etiology in Paget's disease of bone.

Animals↗
PubMed1980

[Parkinson's disease, dysautonomy, and auto-antibodies directed against sympathetic neurones (author's transl)].

A study was conducted to evaluate possible correlations between auto-antibodies directed against sympathetic structures (Ab. S), in Parkinson's disease and the dysautonomy that may be associated with it, in 85 Parkinsonian patients and 85 controls. In all the patients with Parkinson's disease, the immunological study was coupled with an evaluation of functional signs of anomalies of neurovegetative function, and tests for postural hypotension. The results confirm the remarkable frequency of these auto-antibodies in patients with Parkinson's disease (66%), whereas they were present in only 20% of control subjects. Positive results were more frequent in early onset, long-standing cases. The presence of Ab. S in 85% of the pateints in whom the disease had started before 50 years of age could mean that these antibodies might constitute a marker for Parkinson's disease among other parkinsonian conditions. No correlation between Ab. S and the existence of a dysautonomy was found, but their frequency is slightly higher in patients with Parkinson's disease and postural hypotension (75%). This finding, together with the frequency and plurality of the mechanism of postural hypotension in elderly subjects, suggests a correlation with some types of postural hypotension.

Aged↗
PubMed1979

[Demonstration by immunofluorescence and immunoperoxidase of an antigen of the measles type in the osteoclasts of Paget's disease of bone].

The intra nuclear and intra cytoplasmic inclusions described in osteoclasts in PAGET's bone disease are morphologically similar to those observed in subacute sclerosing panencephalitis. Immunological techniques using different specific immune sera demonstrate the presence of an antigenic structure of viral origin in osteoclasts in PAGET's bone disease. A measles or a measles like virus is most likely to be involved and may play a role in the etiology of the disease.

Antigens, Viral↗
PubMed1975

Autoantibodies to prolactin-secreting cells of human pituitary.

A new autoantibody which reacted with anterior-pituitary tissue was deteected by immunofluorescent staining. Of 287 patients having one or more autoimmune endocrine diseases, sera from 19 reacted with pituitary glands obtained at hypophysectomy for breast cancer. Using specific rabbit antibodies to each of the six pituitary hormones and rhodamine-labelled goat-anti-rabbit-immunoglobulin (Ig) followed on the same unfixed cryostat section by a patients's serum counterstained with fluorescein-conjugated sheep-anti-human-Ig, it was posssible to show that the autoantibodies reacted specifically with the hypertrophied prolactin cells in these glands. The antibodies, belonging to the 3 main Ig classes, were complement fixing, with titres varying from 1 to 80. Double staining of prolactin cells and analogy with other autoimmune systems suggested that the antigen is in cytoplasmic organelles involved in the synthesis or delivery of the hormone. No pituitary antibodies were found in panhypopituitary cases, but there are indications that antibodies to other pituitary cells exist in some sera and that an autoimmune process may account for some cases of isolated pituitary hormone defects occurring in adult life.

Adolescent↗