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Biomedical subjects

A Postma

Publications and source records attributed to A Postma.

At least 19 recordsLinked to original sources

Spatial and temporal characteristics of visual motion perception involving V5 visual cortex.

The anatomical substrates of the perception of motion have not yet been established in a detailed way on an individual level. The aim of this study was to develop a systematic procedure for mapping the visual cortex using Transcranial Magnetic Stimulation (TMS). The results showed that such an individual and detailed map of the spatial and temporal characteristics of motion perception can be constructed using TMS.

Adult↗

Effects of slow rTMS at the right dorsolateral prefrontal cortex on EEG asymmetry and mood.

In a sham-controlled design (n = 12), slow repetitive transcranial magnetic stimulation (rTMS) was applied to the right dorsolateral prefrontal cortex for 20 min, and the subsequent effects on mood and the EEG spectrum were investigated, Analysis revealed a significant left hemisphere increase in EEG theta activity at 25-35 and 55-65 min after stimulation. In addition, participants reported significant decrease in anxiety immediately after stimulation, as well as 35 and 65 min after rTMS. These findings indicate that reductions in anxiety after slow rTMS at the right dorsolateral prefrontal cortex are associated with a contralateral increase in theta activity.

Adult↗

Prearticulatory and postarticulatory self-monitoring in Broca's aphasia.

The present study examined to what extent patients with Broca's aphasia and healthy controls rely upon prearticulatory and postarticulatory monitoring processes for detecting and repairing errors in speech production. Monitoring skills were investigated in a speaking situation with normal auditory feedback, a speaking situation with white noise, and a situation in which errors had to be detected in other-produced speech. The results demonstrated that the Broca's aphasics repaired a lower percentage of errors than the controls in the situation with normal auditory feedback, whereas their performance in the noise-masked condition was comparable. In contrast to the controls, the aphasics did not suffer from the presence of white noise. In addition, the proportion of covert repairs was higher for the Broca's aphasics than for the healthy controls. These findings indicate that Broca's aphasics concentrate primarily on prearticulatory monitoring. Possible explanations for this strong reliance on prearticulatory monitoring processes are discussed.

Adult↗

Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesions.

The current meta-analysis included 27 studies on spatial-memory dysfunction in patients with hippocampal damage. Each study was classified on the basis of the task that was used, i.e., maze learning, working memory, object-location memory, or positional memory. The overall results demonstrated impairments on all spatial-memory tasks. Clear differences in effect size were found between positional memory on the one hand and maze learning, object-location memory, and working memory on the other hand. Lateralization was found only on maze learning and object-location memory. These findings clearly indicate that specific aspects of spatial memory can be affected in various degrees in patients with hippocampal lesions. Moreover, these results strongly support the notion that the hippocampus is important in the processing of metric positional information, probably in the form of an allocentric cognitive map.

Animals↗

Effects of time pressure on mechanisms of speech production and self-monitoring.

The purpose of the present study was to examine effects of time pressure on mechanisms of speech production and self-monitoring. The most widely accepted monitoring theory (Levelt, 1989) suggests that monitoring proceeds through language perception, that is, speech error detection is primarily based on the parsing of one's own inner and overt speech. Twenty-four subjects described visual networks at two different rates (normal and fast). The time pressure manipulation affected a number of temporal characteristics: the error to cutoff and cutoff to repair times were shorter in the fast than in the normal condition. The results indicate that the monitor adjusts its speed of error detection and repair planning to the faster speech output rate. The time pressure manipulation did not affect the accuracy of error detection. The implications for the perception theory of monitoring are discussed.

Adolescent↗

Effects of divided attention on the production of filled pauses and repetitions.

The purpose of the present study was to examine effects of divided attention on the production of filled pauses and repetitions. Attention was divided by means of a dual-task paradigm. Eighteen nonstuttering adult subjects performed a picture story-telling task, with and without simultaneously performing a tactile-form recognition task. Results indicate that the number of filled pauses and repetitions increased in a situation of divided attention. This suggests that the production of filled pauses and repetitions, which are considered to be reactions to problems in speech planning, is governed by processes that operate relatively independently of the available attentional resources. It was speculated that these disfluencies could be automatic reactions to the increased planning difficulties induced by the concurrent task.

Adult↗

Detection of errors during speech production: a review of speech monitoring models.

In this paper three theories of speech monitoring are evaluated. The perception-based approach proposes that the same mechanism employed in understanding other-produced language, the speech comprehension system, is also used to monitor one's own speech production. A conceptual, an inner, and an auditory loop convey information to a central, conscious monitor which scrutinizes the adequacy of the ongoing speech flow. In this model, only the end-products in the speech production sequences, the preverbal (propositional) message, the phonetic plan, and the auditory results, are verified. The production-based account assumes multiple local, autonomous monitoring devices, which can look inside formulation components. Moreover, these devices might be tuned to various signals from the actual speech motor execution, e.g. efferent, tactile, and proprioceptive feedback. Finally, node structure theory views error detection as a natural outflow of the activation patterns in the node system for speech production. Errors result in prolonged activation of uncommitted nodes, which in turn may incite error awareness. The approaches differ on the points of consciousness, volition and control, the number of monitoring channels, and their speed, flexibility, and capacity, and whether they can account for concurrent language comprehension disorders. From the empirical evidence presently available, it is argued for a central perception-based monitor, potentially augmented with a few automatic, production-based error detection devices.

Humans↗

Spatial working memory performance after high-frequency repetitive transcranial magnetic stimulation of the left and right posterior parietal cortex in humans.

The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) at the left or right posterior parietal cortex were studied using a spatial working memory task. Eight subjects were stimulated over the P3 and P4 electrode site at 115% of the motor threshold (frequency 25 Hz, trains of 200 ms) during the 1000-ms delay of the spatial working memory task, or received sham stimulation. It was found that the reaction times were slower during right-parietal rTMS than during left-parietal rTMS. No differences were found between the percentages correct responses. These results are in line with recent neuroimaging findings and data from patients with cerebral lesions, suggesting that the posterior parietal cortex is especially involved in spatial processing, and provide converging evidence for recent theories on hemispheric specialization.

Adult↗

Laterality effects in selective attention to threat after repetitive transcranial magnetic stimulation at the prefrontal cortex in female subjects.

Recently, several experiments have indicated that the left and right prefrontal cortex (PFC) are differently involved in emotional processing. The aim of this study was to investigate the role of the left and right PFC in selective attention to angry faces by using a pictorial emotional Stroop task. Slow repetitive transcranial magnetic stimulation (rTMS) was applied to the left and right PFC of 10 female subjects for 15 min on separate days. Results showed a significant effect of stimulation position: right PFC rTMS resulted in selective attention towards angry faces, whereas left PFC rTMS resulted in selective attention away from angry faces. This finding is in accordance with theoretical accounts of the neural implementation of approach and withdrawal systems.

Adult↗

Low-dose daunorubicin in induction treatment of childhood acute lymphoblastic leukemia: no long-term cardiac damage in a randomized study of the Dutch Childhood Leukemia Study Group.

BACKGROUND: To investigate late cardiotoxicity in childhood acute lymphoblastic leukemia (ALL) survivors after induction treatment with or without daunorubicin (DNR; 25 mg/m(2), i.v., weekly, x4, cumulative dose 100 mg/m(2)). PROCEDURE: Cardiac function was assessed in 90 event-free survivors of childhood ALL, 11.4-17.8 years (median 14.8 years) after treatment according to the DCLSG protocol ALL V. In this protocol patients were randomized to receive (group B) or not to receive (group A) DNR 25 mg/m(2)/week i.v. during the first 4 weeks of induction treatment. Age at diagnosis was 1.2-14.9 years (median 4.5 years). The cardiac evaluation consisted of a history, physical examination, electrocardiogram (ECG), 24 hr ambulatory ECG, and echocardiography. RESULTS: Electrocardiographic data, arrhythmias, left ventricular dimensions, left ventricular contractility, wall stress, and diastolic function were within normal limits in both groups. No difference could be shown between data from group A (n = 40) and group B (n = 50). CONCLUSIONS: No late cardiac damage was demonstrated in childhood ALL survivors after induction treatment including a cumulative dose of 100 mg/m(2) DNR, compared to survivors who received the same treatment but without DNR. DNR 100 mg/m(2) given in 4 doses of 25 mg/m(2)/week appears to be a safe dose in induction treatment of ALL.

Adolescent↗

Spatial localization in patients with unilateral posterior left or right hemisphere lesions.

In this study, perceptual and visuomotor spatial localization were examined in patients with unilateral right (RH) or left (LH) hemisphere lesions and in a group of control subjects. Perceptual localization was measured with a position-discrimination task; in the visuomotor localization task, subjects had to point to a visual target. Both tasks were investigated in conditions with or without background visibility and with central and peripheral targets. In the visuomotor task, hand visibility was also manipulated. In both tasks, targets were presented in the left and right visual hemifield. The perceptual task revealed impairments for both LH and RH patients in the contra-lateral visual hemifield. RH patients also revealed slightly larger impairments in conditions without a visual background. In the visuomotor task, the LH patients were not impaired, whereas the RH patients were impaired in conditions without hand visibility and/or background visibility. Hence, our data strengthen the idea that spatial localization is not a unitary function and that perceptual and visuomotor localization can be selectively impaired. We suggest that one of the important factors distinguishing between localization impairments in RH and LH patients might be absolute versus relative localization.

Adult↗

Memory for object locations in Korsakoff's amnesia.

Deficits in spatial context memory are an important characteristic of Korsakoff's amnesia. In memory for spatial context information, there is evidence for a functional dissociation of three separate processes: (1) binding of object information to locations (i.e. binding complex memories), (2) exact, metric processing of Euclidean co-ordinates, and (3) an integration mechanism. In the present study, these sub-mechanisms were assessed experimentally in a group of Korsakoff patients (N = 20) and compared to healthy controls (N = 20) to see whether selective deficits can be demonstrated. It was found that Korsakoff patients display deficits on all three spatial-memory conditions, which are not the primary result of deficits in visuo-spatial construction and memory for object identity. No evidence for selective impairments could be observed. These impairments can be linked to damage of diencephalic regions and perhaps the parietal cortex.

Female↗

Effects of testosterone administration on selective aspects of object-location memory in healthy young women.

Previous work has indicated that object-location memory is sensitive to sex differences as well as variations in the menstrual cycle. The goal of the present study was to further examine the hormonal basis of human spatial memory by assessing the effects of a single dose of exogenous testosterone in healthy young women on three recall conditions: positional reconstruction; object-to-position-assignment; and the combined condition in which subjects both have to reconstruct the precise locations and to link the different objects to the correct places. In the latter condition, delayed recall (3 min delay) improved with testosterone. Although the effects were only small and need further substantiation, they support the idea that testosterone may have an activational effect on selective aspects of cognitive functioning.

Adolescent↗

Frontal-lobe involvement in spatial memory: evidence from PET, fMRI, and lesion studies.

Many studies have identified the prefrontal cortex as the brain area that is critical for spatial memory, both in humans and in other primates. Other studies, however, have failed to establish this relation. Therefore, the aim of this paper was to review the literature regarding the role of the human prefrontal lobe in spatial memory. This was done by examining the evidence obtained from neuropsychological patients and from studies using brain-imaging techniques (PET and fMRI). Evidence supporting the notion that the prefrontal cortex is extensively involved in spatial working memory was found. The majority of these studies, however, suggests that frontal-lobe involvement is not related to the type of material that is being processed (e.g., spatial vs. nonspatial), but to process-specific functions, such as encoding and retrieval. Theoretically, these functions could be linked to the central executive within Baddeley's working-memory model, or to recent theories that emphasize the various processes that play a role in working memory. Also, methodological issues were discussed. Further research is needed to enhance our understanding of the precise interaction of domain-specific and general processes.

Cerebrovascular Circulation↗

Interactions between exogenous auditory and visual spatial attention.

Six experiments were carried out to investigate the issue of cross-modality between exogenous auditory and visual spatial attention employing Posner's cueing paradigm in detection, localization, and discrimination tasks. Results indicated cueing in detection tasks with visual or auditory cues and visual targets but not with auditory targets (Experiment 1). In the localization tasks, cueing was found with both visual and auditory targets. Inhibition of return was apparent only in the within-modality conditions (Experiment 2). This suggests that it is important whether the attention system is activated directly (within a modality) or indirectly (between modalities). Increasing the cue validity from 50% to 80% influenced performance only in the localization task (Experiment 4). These findings are interpreted as being indicative for modality-specific but interacting attention mechanisms. The results of Experiments 5 and 6 (up/down discrimination tasks) also show cross-modal cueing but not with visual cues and auditory targets. Furthermore, there was no inhibition of return in any condition. This suggests that some cueing effects might be task dependent.

Adult↗

Academic career after treatment for acute lymphoblastic leukaemia.

AIM: To evaluate academic career in long term survivors of childhood acute lymphoblastic leukaemia (ALL), in comparison to their healthy siblings. PATIENTS: Ninety four children treated for ALL with cranial irradiation 18 or 25 Gy and intrathecal methotrexate as CNS prophylaxis. Median age at evaluation was 20 years; median follow up since diagnosis was 15 years at the time of the study. METHODS: Patients and their 134 siblings completed a questionnaire on school career. The percentage of referrals to special primary schools for learning disabled, and the final level of secondary education in patients and siblings were compared, using a six point classification. Within the patient group, the effect of possible risk factors (age at diagnosis, irradiation dose, and gender) was investigated. RESULTS: Significantly more patients than siblings were placed in special educational programmes. A significant difference was found for level of secondary education. No effect of gender or irradiation dose was found, but younger age at diagnosis was significantly related to both referrals and school levels. CONCLUSION: Treatment for childhood ALL with cranial irradiation and chemotherapy at a young age is clearly associated with poorer academic career.

Adolescent↗

Spatial memory impairment in patients after tumour resection: evidence for a double dissociation.

Human spatial memory can be divided into multiple, partly separate cognitive processes. In this study, object location memory was studied using a set of tasks that assessed three different spatial memory aspects: positional memory, object location binding, and a combined process. Also, maze learning and spatial span memory were measured. Ten patients who had undergone intracranial tumour resection participated, and their individual results were compared with control data from 24 healthy subjects. Four patients showed selective spatial memory impairments; two patients were impaired at positional memory, and two other patients were impaired on object location binding and the combined process. This double dissociation provides further evidence for the notion that object location memory is not a unitary system, but consists of at least two separate mechanisms. In addition, spatial memory problems were predominantly present in the patients with lesions in either the right hemisphere or in the parietal lobe. These results are in agreement with previous findings on the involvement of the right hemisphere and the posterior parietal cortices in spatial processing.

Adult↗