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Biomedical subjects

A Poli

Publications and source records attributed to A Poli.

211 records · Page 12Linked to original sources
PubMedDate not supplied

Analysis of renal immune-deposits in canine leishmaniasis. Preliminary results.

Previous studies carried out on 34 dogs spontaneously infected by Leishmania infantum showed the presence of kidney lesions characterized by immunologically mediated glomerular and tubular damage. Glomerular immune-deposits were studied in 13 of these dogs. Immunoglobulins were isolated from kidney tissues by acid elution; IgG fractions from eluates, obtained by ammonium sulfate precipitation, were subjected to clonotypic analysis by autoradiography after isoelectrofocusing (IEF) using 125I radiolabelled goat IgG fraction-anti Fab2 of dog IgG. Idiotypic characterization of IgG eluted from kidney tissues was performed by IEF and autoradiography using both 125I radiolabelled membrane antigens of L. infantum extracted by Triton x 100 and 125I radiolabelled dog IgG for rheumatoid or anti-idiotypic activity. The IgG deposited in the kidney tissues of examined dogs were polyclonal and a specific activity against Leishmania membrane antigens was revealed. Meanwhile an anti-IgG activity of deposited immunoglobulins was not observed.

Animals↗
PubMedDate not supplied

[The pharmacologic action of extracts of Polygonum punctatum Elliot (= P. acre HBK)].

In vivo pharmacological studies were carried out with the aqueous and hydroalcoholic extracts of P. punctatum Elliot. Previously we have made a phytochemical screening and a essay of acute toxicity. The extracts exhibited an inhibition of the carrageenan-induced rat paw oedema, at doses of 300 and 600 mg.kg-1 p.o. and the hydroalcoholic extract at a dose range of 100-600 mg.kg-1 p.o. reduced significantly the increase of the vascular permeability induced by histamine. The extracts showed antipyretic activity only by i.p. administration. The gastrointestinal propulsion of a charcoal suspension was affected by both extracts, but significantly only by the aqueous extract. They elicited bradycardia and lowered the arterial blood pressure, but they do not demonstrate analgesic and diuretic activities. The pharmacological effects assayed are discussed in relation to the chemical composition of this plant and also to its popular use.

Animals↗
PubMedDate not supplied

Regression of the atherosclerotic lesion in man: the impact of noninvasive techniques.

Experimental studies demonstrate that atherosclerotic plaques induced in animals can regress following appropriate treatment, but evidence in favour of the regression of atherosclerotic lesions in man is still scanty. New imaging techniques, such as high resolution B-mode echotomography, allow the visualization and measurement of anatomical parameters of the arterial wall in sample arteries of human patients "in vivo", introducing the possibility of a much more precise monitoring of early atherosclerotic lesions. New information on the natural history of atherosclerotic disease in man, including the possibility of differentiating between lesions of different clinical significance, can be expected from the wide application of these techniques to atherosclerosis research. A more precise testing of diets, drugs and physical procedures intended to obtain the regression of atherosclerosis in human beings will also be possible.

Animals↗
PubMedDate not supplied

[Leiomyosarcoma of the inferior vena cava: description of a new case and review of the literature].

A case of primary leiomyosarcoma of the inter-renal vena cava is reported. This tumor is rare and up to date no more than 100 cases have been reported. Surgical treatment consisted in the removal of vena cava from the iliac veins to the suprahepatic veins with right nephrectomy. Restoration of vena cava and left renal vein continuity was not necessary because of the presence of collateral venous circulation at the time of operation. Venous ligation was haemodynamically well tolerated and the patient is disease-free at one year from operation. However, despite surgical radicality, prognosis remains poor given the frequency of metastases reported in more than 35% of cases.

Female↗
PubMedDate not supplied

[Effects of seat belt legislation on injuries of traffic accidents].

This paper reports a comparison of road injuries and fatalities in the twelve months before and after the mandatory enforcement of seat belt buckling (Law no. 143/89) in to area of Verona. In the post-legem period among hospital admitted subjects a significant reduction of injured/accidents ratio was recorded (reduction of 5.3 percent points C.I. 95%: 3.09-7.5 corresponding to a decrease of 29%: p < 0.001) in the same period the number of decreased was lower 12 vs. 19) but the deceased/accidents and the deceased injured ratios were not significantly different. The comparison of distribution of lesions into different body areas showed a sharp decrease of common head trauma (reduction of 14.7 percent point, C.I. 95% 8.20-21.22 corresponding to a decrease of 50.3%: p < 0.001) with a parallel but not significant reduction of subjects with short hospitalization (< or = 3 days. No differences were found for severe trauma frequencies and for overall hospitalization length.

Accidents, Traffic↗