Search PubMed⌕ Search

Biomedical subjects

A Polak

Publications and source records attributed to A Polak.

134 records · Page 8Linked to original sources
PubMedDate not supplied

Combination of amorolfine with various antifungal drugs in dermatophytosis.

The fungistatic activity of ketoconazole, griseofulvin and terbinafine alone and in combination with amorolfine was tested in casitone agar. The fungistatic activity of all three against Trichophyton mentagrophytes is slightly increased by the addition of amorolfine. In yeasts the results are not so clear. The combinations of amorolfine with griseofulvin, terbinafine, itraconazole and fluconazole were always more efficient in a murine model of dermatophytosis than the monotherapy, thus a clear synergism between amorolfine and other antifungals was seen.

Animals↗
PubMedDate not supplied

Kinetics of amorolfine in human nails.

Amorolfine penetrates rapidly into the nail after topical application. The kinetics of penetration follow an exponential law as expected, and the level of amorolfine measured in the nail (at least in the upper levels) already exceeds the MIC of most fungi causing onychomycosis after only 24 h of contact. After topical application amorolfine is detectable in the nail earlier and in higher concentrations than terbinafine and itraconazole after oral application.

Administration, Topical↗
PubMedDate not supplied

Antifungal combination therapy in localized candidosis.

A mouse model of localized candidosis in air-filled subcutaneous cysts imitating thrush has been developed. We have now tested various antifungal combinations in this animal model. Flucytosine (5-FC) + amphotericin B (Amph B) showed the highest efficacy, a clear additive or even synergistic effect was seen. The combination of 5-FC + imidazole or triazole derivative was less efficacious, an additive effect was rare. The combination of 5-FC + Amph B was also tested against Candida albicans strains showing various degrees of 5-FC-resistance. A significant reduction in 5-FC-resistant mutants was seen after the treatment with the combination.

Amphotericin B↗
PubMedDate not supplied

The effects of amorolfine and oxiconazole on the ultrastructure of Trichophyton mentagrophytes. A comparison.

Amorolfin applied in concentrations of 0.1-100 micrograms ml-1 caused considerable damages to the ultrastructure of Trichophyton mentagrophytes: Electron-transparent areas appear in the cytoplasma. The cell wall increases in thickness. Extracytoplasmic membrane vesicles are formed and deposited in the cell wall. Starved fungal cells, with normal ultrastructure, can be found. Lysed, dead cells demonstrate the process of final, vigorous ultrastructural damage. The feature of the damage caused by amorolfin is comparable to that effected by azole antifungals. The characteristics of the ultrastructural changes are similar to those due to amorolfin in the yeast species Candida albicans.

Antifungal Agents↗
PubMedDate not supplied

Methylprednisolone pulses and urine electrolyte excretion.

The mineralocorticoid activity of methylprednisolone pulses was assessed by measurement of urine electrolyte excretion prior to and during alternate day pulsing in patients with skin or joint disease. Two groups were studied: the first receiving pulses, but no other steroid; the second having taken oral prednisolone prior to and during pulsing. Urine sodium excretion in 24 hr urine specimens from both groups was suppressed, with no rebound between pulses, but a gradual "escape" occurred from the effects of continued pulsing. Four hour urine collections demonstrated suppression of urinary sodium excretion for up to 32 hr after pulsing with gradual recovery. The peak recovery in sodium excretion coincided with the subsequent pulse and was insufficient to compensate for the preceding sodium retention. Alternate day pulsing does not, therefore, reduce the risk of sodium retention from large doses of methylprednisolone.

Electrolytes↗