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Biomedical subjects

A Poggi

Publications and source records attributed to A Poggi.

At least 145 records · Page 8Linked to original sources
PubMed1981

Bone changes in end-stage oxalosis.

Primary hyperoxaluria is a rare metabolic disease characterized by exaggerated production of oxalic acid. Clinically the disease is characterized by recurrent calcium nephrolithiasis, progressive renal failure, and early death in uremia. As the regular dialysis treatment may prolong survival, a new syndrome may develop. This is due to intense and continuous deposition of calcium oxalate crystals in soft and bone tissues. The radiologic aspects of oxalate deposition in four adult patients on chronic renal dialysis with histologic and clinical evidence of massive bone oxalosis are reported.

Adolescent↗
PubMed1981

Interaction between heparin and adriamycin in mice bearing the Lewis lung carcinoma.

The investigation was prompted by the observation that adriamycin can interact with heparin in vitro and reduces its anticoagulant activity in ex vivo tests in humans. The possible interactions between these two drugs were studied in C57Bl/6J mice bearing the Lewis Lung Carcinoma (3LL). The anticoagulant activity of heparin was temporarily reduced by concomitant treatment with adriamycin, as indicated by both activated partial thromboplastin times and blood recalcification times. In contrast, no changes were found in the kinetics of adriamycin disappearance from blood and accumulation in tissues if mice had been pretreated with heparin. Moreover, the effect of adriamycin on tumour and metastasis growth was unchanged by the association with the anticoagulant. These data indicate that the short-lived interaction between adriamycin and heparin, which can be documented by coagulation tests, does not necessarily involve a modification in the anticancer activity of the anthracycline.

Animals↗
PubMed1980

Cardiothoracic ratio as a guide to ultrafiltration therapy in dialyzed patients.

This study evaluated the cardiothoracic ratio (CTR) and the roentgenologic heart volume (RHV) as indexes of body fluid retention in 37 uremics on maintenance dialysis therapy. Both indexes related to a highly significant degree with the variations of body fluids balance assessed by the changes in body weights. Cardiomegaly (CTR greater than .500) subsided with adequate ultrafiltration therapy in most patients including those having blood pressure values within the normal range. It is concluded that the measurements of CTR provides an useful guide to ultrafiltration therapy especially in those patients whose blood pressure fails to sense the body fluid retention.

Adult↗
PubMed1980

Bone oxalosis and renal osteodystrophy.

Bone biopsy specimens from four patients with hyperoxaluria who underwent hemodialysis were studied. Calcium oxalate crystals are laid down in marrow spaces and sometimes inside the bone matrix and uncalcified osteoid tissue. They are clearly visible by polarizing microscope and are stained grayish-brown by Pizzolato's method. Most are surrounded by basophilic, amorphous material. By electron microscope they appear as elongated, empty spaces and after hydrogen peroxide treatment appear as fragmented, slightly electron-dense, needle-like structures. In marrow spaces, oxalate crystals aggregate in round clusters surrounded by a granulomatous reaction. This, however, cannot remove the oxalate crystals. Bone histology shows advanced renal osteodystrophy, ie, severe osteomalacia and hyperparathyroidism. The granulomatous reaction induced by the oxalate crystals probably contributes to and worsens the changes from hyperparathyroidism.

Adolescent↗
PubMed1979

Evidence that cells from experimental tumours can activate coagulation factor X.

The procoagulant activity of cells from some experimental tumours isolated in culture or in single-cell suspensions from ascitic fluid was investigated. Cells from Lewis lung carcinoma (primary and metastasis), Ehrlich carcinoma ascites and JW sarcoma ascites were able to shorten markedly the recalcification time of normal, Factor VIII- and Factor VII-deficient but not of Factor X-deficient human plasma. The same cells generated thrombin when mixed with a source of prothrombin and Factor X, absorbed bovine serum (as a source of Factor V), phospholipid and calcium chloride. Thrombin formation was not influenced by the presence of Factor VII. Cells from Sarcoma 180 ascites were completely inactive in both test systems. It is concluded that cells from some experimental tumours have the capacity to activate Coagulation Factor X directly. These findings suggest the existence of an alternative "cellular" pathway in the initiation of blood clotting distinct from both the intrinsic and extrinsic mechanisms.

Animals↗
PubMed1977

Ditazole and platelets III. Effect of ditazole on tumor-cell induced thrombocytopenia and on bleeding time in mice.

Ditazole (4,5-diphenyl-2-bis-(2-hydroxyethyl)-aminoxazol) inhibits in vivo platelet aggregation induced in mice by intravenous injection of cells derived from an experimental tumor, the Lewis lung carcinoma. Such a protective effect of ditazole could not be observed when the number of circulating platelets dropped slowly following intramuscular implantation and spontaneous dissemination of the same cancer cells. These results support previous observations suggesting a different mechanism for the thrombocytopenia observed after intravenous and intramuscular injection of cancer cells. Tail transection bleeding time of normal mice is significantly prolonged by ditazole, a finding at variance with that reported in rats.

Animals↗