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Biomedical subjects

A Pirrelli

Publications and source records attributed to A Pirrelli.

At least 73 records · Page 4Linked to original sources
PubMed1987

Antihypertensive efficacy and tolerability of captopril in the elderly: comparison with hydrochlorothiazide and placebo in a multicentre, double-blind study.

In this study we compared the antihypertensive efficacy and tolerability of captopril at 25 mg twice daily, hydrochlorothiazide (HCTZ), 12.5 mg twice daily and placebo in a multicentre, double-blind, randomized study that included 152 essential hypertensive patients (77 males, 75 females, 87 WHO stage I, 65 WHO stage II, aged 69 +/- 4 years, mean +/- s.d.). Supine and standing blood pressure were similarly reduced by captopril and HCTZ (P less than 0.01 for both compared with placebo). The heart rate did not change. Captopril (25-30 mg twice daily) and HCTZ (12.5 mg twice daily), alone or in combination, maintained their antihypertensive effect during a 24-week single-blind follow-up study. During the follow-up, diastolic blood pressure remained less than 100 mmHg in seven essential hypertensives on placebo, in 45 on captopril and in 25 on HCTZ. Side effects were observed in seven essential hypertensives during placebo (treatment withdrawn in two), in eight during HCTZ and in three during captopril. Serum potassium was reduced (P less than 0.05) and uric acid was increased (P less than 0.01) only during HCTZ. We conclude that captopril and HCTZ have similar antihypertensive efficacy in the elderly; however, captopril appears to be better tolerated.

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PubMed1986

Borderline hypertension: a psychophysiologic approach.

Stress is a condition capable of causing complex psychobehavioral and psychobiological responses, during which blood pressure can reach pathological values. The study reported here investigated the correlation among physiological responses to stress, psychobehavioral assessments, and borderline hypertension. We developed a psychobehavioral questionnaire and submitted patients to a battery of four stressors (mental arithmetic, Sacks's test, white noise, and electric stimulus). We measured levels of muscular contractions, skin conductance, digital temperature, heart rate, and systolic, mean, and diastolic blood pressures. Abnormal psychobehavioral traits and abnormal profiles of physiological responses are more common among borderline hypertensive patients and among patients with a family history of hypertension. The data obtained seem to suggest an interaction of the central nervous system, psyche, and the autonomic nervous system in the origin of hypertension.

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