Search PubMed⌕ Search

Biomedical subjects

A Pietraszek

Publications and source records attributed to A Pietraszek.

At least 19 recordsLinked to original sources
PubMed2006

Preliminary results of mitomycin C local application as post-treatment prevention of vaginal radiation-induced morbidity in women with cervical cancer.

PURPOSE: To determine the usefulness of local mitomycin C application in the prophylaxis of vaginal narrowing after irradiation. MATERIAL AND METHODS: 31 patients with advanced cervical cancer qualified for the study. They underwent brachytherapy with iridium-192 isotope and external beam therapy with linear accelerators. In a blind probe method 16 patients were chosen to have an aqueous solution of mitomycin C applied to the vagina. RESULTS: Radiotherapy caused a shortening of vaginal length in both groups (study and control). In the "mitomycin C group" complete vaginal occlusion was visibly less frequent as were solid fibrotic vault changes. CONCLUSIONS: This mode of morbidity prevention can potentially diminish the occurrence of local vaginal fibrosis and thus may improve patients' quality of life. Further investigations are needed to confirm these results.

Antibiotics, Antineoplastic↗
PubMed2004

Preoperative brachytherapy in endometrial cancer--proposal of a new clinical protocol.

High-dose rate brachytherapy preoperative treatment has been described. The proposal of a protocol contains an outline of patient qualifications for this kind of treatment, as well as necessary laboratory and diagnostic imaging examinations. Methods of brachytherapy (low-dose rate and high-dose rate), methods of surgery and postoperative management of patients with endometrial cancer are discussed.

Brachytherapy↗
PubMed2001

Small cell lung cancer I--III A: cytoreductive chemotherapy followed by resection with continuation of chemotherapy.

OBJECTIVES: To define the place for surgery in combined modality treatment of small cell lung cancer patients. The endpoint was: does complete resection reduce the risk of local failure? METHODS: Between November 1981 and June 1996, 75 patients in stage I--III A, many of them with a bulky cN2 tumor at presentation, were exposed to VP-16 based cytoreductive chemotherapy. After three courses of induction treatment, 46 patients underwent thoracotomy and 35 of them had resection. RESULTS: There were two sudden deaths (pulmonary embolism). No other complications were observed. In six cases (6/35 = 16%), no residual tumor was found in the resected specimen. Four weeks after surgery, chemotherapy was resumed. Three patients experienced local relapse (3/33), among them, the single patient with incomplete resection, and two other patients developed local and distant failure (2/33). Thus, the local relapse rate was 15% (5/33). Eight patients, mainly with chemotherapy induced surgicopathological complete remission (pCR) and with lymph nodes free of tumor in surgical specimens (pN0), are alive, tumor-free, at a median of 136 + months. Two patients died tumor-free at 65 and 147 months. One patient died of unrelated causes at 21 months with no evidence of disease at autopsy. The median survival in the cN0 + N1 subsets was 25.09 months, whereas in cN2 disease, this was 13.75 months. There were no long-term survivors among the patients with persistent N2 disease. The median survival in all 35 patients using the Kaplan--Meier method was 18 months; the 5-year tumor-free survival rate was 29% and the 10-year tumor-free survival rate was 23%. CONCLUSIONS: Satisfactory local tumor control confirmed the assumption of the study. No residual tumor in the resected specimen (pCR) is the most favorable prognostic factor and determinant of long-term survival. Surgery should not be performed in the patients with persistent N2 disease.

Adult↗
PubMed1999

[The role of preoperative brachytherapy in the treatment of early invasive cervical cancer].

The role of preoperative brachytherapy in the treatment of cervical cancer are discussed. Authors described a group of 45 patients with preliminary diagnosis of Io and IIo A sec FIGO tumour. Qualification system to combined treatment and diagnostic procedure are described. Authors discussed methods of LDR therapy. Tubes of 226Ra in Paris technique and afterloading 137Cs Selectron LDR/MDR (of Nucletron BV) were used. Postoperative histopathologic results are compared to preoperative diagnoses established on the basis of clinical examination, US and MRI. Preliminary assessment of tolerance and efficacy of these methods of treatment is made.

Adult↗
PubMed1984

Morphology and function of liver after intravenous and intraportal injections of the immunomodulating agent Propionibacterium granulosum.

An immunomodulator, cell walls from Propionibacterium granulosum strain KP-45 (PG), has been applied in rabbits to test its influence on morphology and function of liver cells. For investigation of distribution in internal organs, the PG preparation was 51Cr-labelled and injected i.v. into mice. Functional liver tests were performed in rabbits injected intravenously or intraportally with PG. Morphologic studies (light and electron microscopy) of liver sections were performed in mice and rats injected intravenously with PG, 1-60 d prior to liver examination. Intravenous or intraportal application of PG did not cause detectable clinical symptoms during the whole observation period (1-60 d). During the first 3-7 d, elevation of serum globulins and transaminases (SGOT, SGPT) were noted with reappearance of normal values after 14-20 d. 131I-labelled Bengal Rose injected into PG-treated rabbits was trapped mostly in the spleen, and to a smaller extent in liver, where radioactivity was significantly lower than in saline-injected control animals. 51Cr-labelled PG injected i.v. into mice were after 60-90 min localized preferentially in lungs and liver, where the radioactivity was much higher than in the spleen. Morphological studies revealed that 6 h following i.v. injection of PG, there appeared partial clearing of the hepatocyte cytoplasm and lowering of their basophilic content with enhancement of pinocytic activity of the hepatocytes. This was accompanied by enlargement of RES cells in liver with enhanced intracellular digestion, higher number of lysosomes and appearance of phagocytic vacuoles.(ABSTRACT TRUNCATED AT 250 WORDS)

Alanine Transaminase↗
PubMed1982

Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation.

Development and growth of skin cancer may be affected by various physical and chemical factors present in human environment. Of these factors electromagnetic radiation of radio- and microwave spectra are among the most common. In the present study Balb/c mice were exposed to chemical carcinogen, 3,4-benzopyrene, painted on the skin every 2nd day for a total of 6 months, and simultaneously irradiated with athermal (5 mW/cm2) or subthermal (15 mW/cm2) doses of 2,450 MHz microwaves. The other group of animals was preirradiated with microwaves at 10 mW/cm2 power level for 1, 2, or 3 months and then treated with benzopyrene, as above. Control mice were exposed for 6 months to benzopyrene, resulting in the development of baso- or spinocellular skin carcinoma within approximately 9 months, and sham-irradiated with microwaves. The growth of the tumour was assessed according to a self-designed 7-range macroscopic scale, supported by microscopical examinations of skin sections. All protocols of microwave irradiations resulted in a significant acceleration of the development of benzopyrene-induced skin cancer and in shortening of life span of the tumour-bearing hosts. This effect seemed to be dose-dependent since subthermal doses (15 mV/cm2) and longer (3 months) expositions to microwaves were more efficient as compared to athermal doses (5 mW/cm2) and shorter preirradiations. In addition, low-level, long-lasting exposure to microwaves led to a marked suppression of delayed hypersensitivity of mice treated with benzopyrene, as assessed by their reactivity to dinitrofluorbenzene (DNFB). It is suggested that the observed co-carcinogenic effect of microwave radiation may, at least in part, result from the inhibitory action of microwaves on cellular immune reactions of exposed animals.

Animals↗