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Biomedical subjects

A Piccaluga

Publications and source records attributed to A Piccaluga.

31 records · Page 2Linked to original sources
PubMedDate not supplied

Acute idiopathic interstitial giant cell myocarditis. A histological and immunohistological study of a case.

The Authors report on a case of acute idiopathic giant cell myocarditis, which occurred in a young man without previous history of immunodeficiency or tumours, and displayed a rapidly fatal clinical course. Autoptic examination showed diffuse damage to the myocardium, with myocytolysis, granuloma formation and abundant giant cell reaction. No significant changes were observed in the other organs and systems . Immunohistochemistry revealed that the giant cells strongly reacted with the antibody KP1--raised to the macrophage-associated antigen CD68--whereas they did not stain with the monoclonal against the muscle-specific marker desmin. In the light of their findings and previous reports in the literature, the Authors discuss the possible origin of giant cells, along with the pathogenesis of the condition.

Acute Disease↗
PubMedDate not supplied

Malignant sarcomatoid mesothelioma of the pleura: a histological and immunohistological study of a case.

The authors describe the case of a 70 year-old asymptomatic female, who showed nodular pleural growths at an occasional chest roentgenogram. Histological examinations and laboratory findings excluded the possibility of an inflammatory granulomatous process, but they did not allow differentiation between malignant sarcomatoid pleural mesothelioma and malignant fibrous histiocytoma. Only at immunohistochemistry was the differential diagnosis made. In fact, the co-expression of vimentin and cytokeratins by neoplastic cells, along with their negativity for macrophage markers strongly supported the hypothesis that the neoplastic growth originated from subpleural mesenchymal stem cells.

Aged↗
PubMedDate not supplied

[Prognostic anatomical features in the colon-rectum carcinoma (author's transl)].

We have reviewed 415 cases of colon-rectum carcinoma in order to establish the most important prognostic anatomical features. Furthermore, we have examined the associated adenomatous polyps, and the possible relationships between anatomical and histological aspects and Dukes stage of carcinoma. We have searched for some useful parameters to decide whether 5 centimeters between neoplasia and resection line is the correct surgical treatment.

Adenocarcinoma↗