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Biomedical subjects

A Pezzoli

Publications and source records attributed to A Pezzoli.

At least 55 records · Page 3Linked to original sources
PubMed1981

'Bis'-fibrinogenaemia.

During routine investigation of plasma proteins by agarose gel electrophoresis, a double fibrinogen band was found in a 79-year-old woman without previous history or clinical symptoms of bleeding tendency. The finding was not associated with prolonged thrombin clotting time, and other routine coagulation tests gave normal results. The plasma fibrinogen concentration was normal when assayed as thrombin clottable protein and by immunological methods. The fibrinogen abnormality was not drug-induced and was apparently unrelated to liver disease. Family studies failed to confirm or exclude its genetic origin.

Aged↗
PubMed1980

Amyloid casts within renal tubules: a singular finding in myelomatosis.

This study was carried out in order to investigate a possible relationship between multiple myeloma and the occurrence of material exhibiting the properties of amyloid within renal tubules. Two groups of autopsied patients, with myelomatosis and benign monoclonal gammopathy were examined for the presence of amyloid deposits in renal and extra-renal sites. Urines were analysed for the presence and amount of Bence Jones protein and the pattern of the associated proteinuria was characterized. Renal tubular casts exhibiting the histochemical characteristics of immuno-amyloid were found exclusively in myeloma patients with Bence Jones proteinuria but without the renal lesions classically described as "myeloma kidney". This finding was independent of the occurrence of immuno-amyloid deposits in other renal and extra-renal sites, suggesting involvement of local factors in the pathogenesis of amyloid formation and deposition within renal tubular lumina. The results of present study suggest the conclusion that the presence of amyloid intratubular casts is to be regarded as a peculiar finding in myelomatosis.

Aged↗
PubMed1980

Pseudotumoral (para-articular) amyloidosis in non-myelomatous monoclonal gammopathy.

A case of non-myelomatous monoclonal gammopathy, with the unusual presenting features of recurrent "pseudotumoral" localized amyloid deposits in intimate relation with the shoulder joints, is described. The peculiar anatomo-clinical features, which make this case quite different from the most reported ones of amyloid arthropathy and of localized amyloidosis, are discussed. The pathogenetic implications are analyzed with special reference to the various known mechanisms, none of which seems to provide a completely satisfactory explanation of the genesis of this form.

Aged↗
PubMed1980

Incidence of paraproteinaemia in blood donors.

Paraproteinemia was detected by agarose gel electrophoresis in 13 out of 3,800 apparently healthy blood donors of an Italian district. None of the subjects with a serum M component developed overt B cell malignancy over a prolonged period of observation. The incidence of paraproteinaemia was higher than that reported from previous surveys of similar populations of blood donors in other European countries, possibly due to the sensitivity of the technique adopted for the screening investigation. The main implications of the detection of monoclonal immunoglobulin abnormalities are briefly discussed with particular reference to the possible indications for routine screening of blood donors for the presence of paraproteins.

Adolescent↗
PubMed1980

Nodular lymphoma eventuating into lymphoplasmocytic lymphoma with monoclonal IgM/lambda cold agglutinin and Bence-Jones proteinuria.

A case of nodular lymphocytic (centroblastic/centrocytic) lymphoma that developed within 5 months after the initial diagnosis of lymphoplasmocytic lymphoma is described. The change in the histopathological picture, consisting of the development of a functionally more differentiated B cell neoplasm, occurred in the abdominal lymph nodes while the original pattern persisted in the bone marrow, liver and spleen. The patient was also found to have a serum IgM/lambda monoclonal immunoglobulin exhibiting cold agglutinin activity with specificity for the 'non-I' erythrocyte antigens.

Agglutinins↗
PubMed1979

[Detection of paraproteinemia in blood donors. Results of systematic analysis of 3800 donors in Trieste].

A systematic analysis of plasma protein pattern performed by agarose gel electrophoresis has detected paraproteinemia in 13 out of 3800 blood donors in the district of Trieste. The variations in the incidence of monoclonal gammopathies in surveys of blood donors could be related not only with geographical origin and the age and sex distribution of the population studied but also with the sensitivity of the screening technique employed. The physiopathological and clinical implications of the detection of paraproteins favour the inclusion of the screening plasma electrophoretic analysis among the laboratory investigations for blood donors.

Adolescent↗
PubMed1976

[Considerations about the physiopathological and clinical significance of the oligclonal serum pattern (author's transl)].

The fortuitous report of the change of serum electrophoretic pattern from the oligoclonal to the monoclonal type in a patient with Hodgkin's disease has been the starting point for some considerations about the physiopathological and clinical significance of the oligoclonal serum pattern. The AA. carry out a critical review of the ordinary electrophoretic methods, underlining some problems related to a good visualization of the oligoclonal serum pattern.

Adult↗