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Biomedical subjects

A Persson

Publications and source records attributed to A Persson.

At least 163 records · Page 9Linked to original sources
PubMed1982

Branched-chain amino acids in the treatment of chronic hepatic encephalopathy.

The therapeutic efficacy of orally administered branched-chain amino acids in patients with liver cirrhosis and chronic encephalopathy was examined in a double blind, randomised crossover study. Seven patients with manifest hepatic cirrhosis and encephalopathy of six months' duration or longer ingested 30 g branched-chain amino acids or placebo during two 14-day periods. Psychometric tests and electroencephalograms were used to evaluate cerebral function. Neither clinical observations nor psychometric testing or electroencephalogram indicated a significant difference in the patients' response to branched-chain amino acids as compared with placebo. In four patients given branched-chain amino acids for longer periods (five to 22 weeks), psychometric tests also remained unchanged. The plasma concentrations of these acids after oral intake increased significantly, demonstrating adequate absorption. Basal plasma amino acid concentrations were unchanged, however, after branched-chain amino acid therapy. No side-effects were seen, which indicates that these amino acids are well tolerated as an extra protein supply in patients with chronic hepatic encephalopathy. As compared with placebo, however, no effect of branched-chain amino acids on the encephalopathy could be detected.

Adult↗
PubMed1980

Fetal EEG during vacuum extraction delivery with a special plastic ventouse.

A vacuum extractor cup made of plastic with built-in percutaneous silver electrodes for fetal EEG and ECG registration is described. In an experimental set up the mechanical properties of the cup were tested. The cup electrodes were tested on a 1-month-old infant and a satisfactory recording was obtained. During delivery a technically acceptable fetal EEG was recorded between but not during tractions. Comparison of the EEG before and after two pulls showed a generalized reduction of amplitude and a decrease of rhythmic slow wave activity. The results indicate that a plastic cup with EEG electrodes might be a useful tool in studying fetal cerebral functions during delivery by vacuum extraction.

Electroencephalography↗
PubMed1979

Isoelectric points of spinach thylakoid membrane surfaces as determined by cross partition.

The isoelectric points of unbroken chloroplast lamellae and various subchloroplast fractions, including a preparation of inside-out thylakoids, have been determined using aqueous two-phase systems containing dextran and charged polyethylene glycol. When the amounts of material in the top phase in a phase system with the positively charged trimethylamino polyethylene glycol are plotted against pH the curve intersects the corresponding curve obtained from phase systems with the negatively charged polyethylene glycol sulfonate. This cross-point can be correlated with the isoelectric point of the material. The cross-point for unbroken chloroplast lamellae was found to be around pH 4.7. Mechanical disintegration lowered the cross-point to around pH 4.4, probably because of exposure of new membrane surfaces. The disintegrated chloroplasts were fractionated by differential centrifugation to separate the grana and stroma lamellae. The stroma lamellae vesicles showed the same isoelectric point as the unbroken lamellae, while a cross-point at pH 4.3 was obtained for the grana-enriched fraction. For thylakoid membranes destacked under low salt conditions the cross-point was 0.3 pH unit lower than for membranes originating exclusively from the stroma lamellae. The most acidic crosspoint (pH 4.1) was observed for the fraction enriched in inside-out granathylakoids. It is suggested that the differences in isoelectric point between various subchloroplast fractions reflect a heterogeneous arrangement of surface charge along and across the thylakoid membrane.

Cell Fractionation↗
PubMed1979

The treatment of total ruptures of the Achilles tendon by plaster immobilisation.

Twenty patients with total rupture of the achilles tendon were treated by immobilisation in plaster in the gravitation-equinus position for eight weeks. All were healthy persons with a mean age of forty-three years. After removal of the plaster, seven patients had a re-rupture, four of whom were treated by operation, whilst two others sustained a deep vein thrombosis with an associated pulmonary embolus in one case. At follow-up, between 6 and 29 months after the rupture, 16 patients had no complaints and the remaining four had only minor problems. The range of motion in the ankle joint was normal in all patients and the strength in the affected calf was restored to normal in the majority. However, the strength recovered less in those patients with re-rupture who were treated conservatively for the second time. Because of the high complication rate we consider plaster treatment inferior to surgical treatment of Achilles tendon rupture.

Achilles Tendon↗
PubMed1978

EEG studies on patients with chronic obsessive-compulsive neurosis before and after psychosurgery (stereotaxic bilateral anterior capsulotomy).

In 35 patients with chronic severe obsessive-compulsive neurosis the EEG was studied before, shortly after (10 days) and 1--2 years after a psychosurgical intervention (stereotaxic bilateral anterior capsulotomy). The preoperative EEG was completely normal or borderline in most of the patients (94%). After surgery EEG changes appeared in 90% of the patients. In most of them (75%) these consisted in bilaterally synchronous bursts of rhythmic slow waves with a maximum in the frontal regions. No consistent change of the alpha activity could be found. At the follow-up examinations most of the EEGs (79%) showed the same pattern as at the preoperative control. No focal or epileptiform abnormalities were observed, either at the immediate postoperative or at the follow-up examination.

Adult↗
PubMed1978

Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.

Thirty established cell lines from solid human tumors were typed by the mixed hemadsorption technique with respect to the HLA-A and HLA-B and partly also the HLA-C series. All cultures exhibited unique antigenic patterns. The discriminatory potential was further increased very much taking into consideration one as yet undefined antigen series tentatively named Ek-1 to Ek-11. Sixteen cell lines not designated as HeLa cells but on various non-immunological indications suspected to be HeLa cell contaminants, all gave, with our present test, the same antigenic composition as HeLa cells or clones thereof. The mixed hemadsorption reaction is a highly sensitive and convenient method for immunological typing of cells in monolayer cultures. Some important implications of this are discussed.

Antigens, Neoplasm↗
PubMed1978

EEG-changes during general anaesthesia with enflurane (Efrane) in comparison with ether.

The effects of enflurane (efrane) and ether on the cerebral functions were studied by EEG on two similar groups of adult patients. For basic comparison a depth of anaesthesia was chosen which permitted abdominal surgery without the need to administer muscular relaxants. At this level of anaesthesia the typical EEG-changes of paroxysmal type which have been described with enflurane were seen only occasionally. If, however, the depth of anaesthesia was further increased, such EEG-changes indicating increased cerebral excitability were seen more often under enflurane and also appeared under ether anaesthesia. No seizure activity was recorded.

Adult↗
PubMed1975

Drainage of thoracic duct lymph in twelve patients with myasthenia gravis.

The effect of thoracic duct lymph drainage (5-34 days) in 12 patients with myasthenia gravis on muscular function has been followed for 5-43 months. Among the results obtained were: (1) During the drainage the myasthenic symptoms decreased markedly after 1-4 days and remained so during the drainage. (2) The doses of cholinesterase inhibitors had to be markedly reduced during the lymph drainage in eight patients. (3) Discontinuation of the lymph drainage increased the myasthenic symptoms within a few days. However, after a median observation time of 14 months with conventional treatment all but one of the patients had improved. (4) Retransfusion of the patients own cell-free lymph caused a worsening of the myasthenic symptoms. This effect could also be obtained following infusion of IgG preparations from the patients lymph. Three retransfusions of cell suspensions obtained from the thoracic duct lymph from two patients had no effects on their myasthenic symptoms. (5) It is suggested that thoracic duct lymph drainage can be combined with other forms of treatment in severe cases of myasthenia gravis.

Adrenocorticotropic Hormone↗