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Biomedical subjects

A Perry

Publications and source records attributed to A Perry.

178 records · Page 10Linked to original sources
PubMedDate not supplied

Deletion of the NF2 region in both meningioma and juxtaposed meningioangiomatosis: case report supporting a neoplastic relationship.

We report a case of juxtaposed atypical meningioma and meningioangiomatosis (MA) in an 8-year-old boy with no clinical stigmata or family history of neurofibromatosis. We studied the proliferative activity and genetic changes in the two lesions in an attempt to define their biologic and pathogenetic relationships. The MIB-1 index was 11% in the meningioma and <1% in the MA, indicating increased proliferative activity in the meningioma. Fluorescence in situ hybridization was done for two chromosomal regions commonly deleted in meningiomas. There was loss of the neurofibromatosis 2 locus (22q12) in both the meningioma and MA. Conversely, the region of 1p32 was not deleted. Our results indicate that both the meningioma and MA arose from the same clonal process, with the meningioma probably undergoing additional, but undefined, genetic alterations that confer upon it a more proliferative potential. This loss of 22q12 in the MA raises doubt about the presumed hamartomatous nature of MA.

Antigens, Nuclear↗
PubMedDate not supplied

Question of 'patients' versus 'clients'.

Our study showed that of the 300 consecutive people interviewed at the General Hospital at Port-of-Spain, Trinidad, most persons (80%) preferred to be called 'patients' as opposed to 7% choosing the term 'client' and 6% opting for the term 'customer'. This proves our hypothesis that in the developing world people prefer to maintain the doctor-patient relationship and leave the word 'client' and 'customer' for the businessman.

Adolescent↗
PubMedDate not supplied

Fibrous meningioma with tyrosine-rich crystals.

A 58-year-old African-American woman presented with a 6-month history of headaches. A magnetic resonance imaging scan of the head revealed a 5-cm, enhancing dura-based mass in the left parietal region. The variably cellular tumor was composed of uniform spindle cells associated with intercellular collagen and numerous radially arranged "petal-shaped" clusters of eosinophilic crystals. The tumor was diagnosed by light microscopy as a fibrous meningioma. Ultrastructural examination disclosed cells with complex interdigitating processes connected by desmosome-like cell junctions, abundant intercellular collagen fibers, and prominent, densely osmiophilic crystals featuring radiating teardrop shaped petals emanating from a central core. A positive Millon reaction showed these crystals to consist at least in part of tyrosine. By morphology, histochemistry, and ultrastructure, the crystals resembled tyrosine-rich crystals occurring in salivary gland tumors. This is the first report of a fibrous meningioma containing tyrosine-rich crystals.

Crystallization↗
PubMedDate not supplied

Pitch change in male-to-female transsexuals: has phonosurgery a role to play?

Male-to-female transsexuals, who have undergone gender reassignment surgery, may continue to have low pitched voices. Voice therapy may assist them to use their voice in a manner more likely to be perceived as female but, if this approach is unsuccessful, a laryngeal framework operation may be necessary to raise vocal pitch. This study assessed the effects of crico-thyroid approximation surgery in 14 transsexuals. Modal pitch was significantly increased by surgery but with substantial variation across speakers. Modal pitch was significantly correlated with judgements of gender by speech and language therapists who listened to tapes of the subjects. The results suggest that crico-thyroid approximation may be used to raise the pitch of voices of male-to-female transsexuals. Further research is needed to clarify the reasons for the variability in outcome, to monitor the longer-term changes in voice and the impact for clients of their modified voice in real life situations.

Adult↗
PubMedDate not supplied

Evaluation of speech in people with head and neck cancer: a pilot study.

BACKGROUND: A paucity of information exists on the effects of cancer on speech, with what little literature exists focussing on the effects of treatment. Baseline assessment of speech in head and neck cancer patients before treatment is important to distinguish accurately the effects of treatment from the effects of the cancer itself. AIMS: This prospective study had four major foci: (1) to determine if speech intelligibility and motor speech functions of patients with head and neck cancer before treatment differed from the normal population; (2) to determine if impairments in speech intelligibility and motor speech functions were specific to the original site of cancer; (3) to determine which motor speech functions were most related to overall speech intelligibility; and (4) to determine whether there was a relationship between self-report of speech intelligibility, motor speech functions and the clinical assessment thereof. This study aimed incidentally to determine whether the Frenchay Dysarthria Assessment is a practicable, valid and reliable tool for assessing speech functions in the head and neck cancer population. METHODS & PROCEDURES: Twenty participants, between 47 and 76 years of age and all newly diagnosed with a cancer of the head and neck, participated in the pilot study. In examining speech, participants completed a self-report questionnaire pertaining to speech intelligibility and motor speech functions and were then assessed clinically using subscales of the Frenchay Dysarthria Assessment before the start of cancer treatment. The motor speech functions examined included: respiratory ability and functions of the lip, soft palate, larynx and tongue. OUTCOMES & RESULTS: Results indicated that participants with head and neck cancer had a greater reduction in both speech intelligibility and in almost all aspects of speech when compared with the normal population. Results further demonstrated that the site of the cancer dictated the type of impairment experienced with respect to speech function. Not all motor speech characteristics correlated with overall speech intelligibility and, lastly, self-report and clinical assessment were significantly correlated with respect to motor speech characteristics, but they differed slightly in the assessment of speech intelligibility. CONCLUSIONS: This pilot study has highlighted the critical importance of collecting baseline measures and reporting functional results according to the cancer site in future research. It has also shown the usefulness of the Frenchay Dysarthria Assessment as a practicable, valid and reliable protocol of motor speech assessment for the head and neck cancer population.

Aged↗
PubMedDate not supplied

A reassessment of spinal stabilization in severe cerebral palsy.

A homogenous population of 37 institutionalized patients with scoliosis and severe cerebral palsy was evaluated to assess the impact of spinal stabilization on comfort, function, health, and ease of nursing care. Through a prospective care-burden study, a 34-month retrospective analysis, and a healthcare worker questionnaire, 17 fused patients with a mean current scoliosis of 35 degrees were compared with 20 nonfused patients with a mean scoliosis of 76 degrees. No clinically significant differences were noted in pain or pulmonary medication utilization or therapy, decubiti, function, or time for daily care. Nevertheless, the majority of healthcare workers believed that the fused patients were more comfortable.

Activities of Daily Living↗
PubMedDate not supplied

Educational issues in teaching dysphagia to speech pathologists.

This paper examines current practices in teaching speech pathology students dysphagia theory and practice in Australia, with comment and contrast from speech pathology courses in the UK. There is wide diversity in terms of the time allocated to this subject on undergraduate courses, in ways of teaching and achieving clinical practicum in these areas and in evaluating the learning outcomes and competence of students. Against the background of changing work experience in the health sector, where dysphagia increasingly forms a significant proportion of a speech pathologist's caseload, the challenge for educators is to provide a dynamic, integrated, modern curriculum where dysphagia forms a significant component of the course. This paper examines some of the current educational issues and discusses teaching and learning paradigms in this area.

Australia↗
PubMedDate not supplied

Patients' perceptions of uncertainty and stress during weaning from mechanical ventilation.

Weaning from mechanical ventilation is physiologically and psychologically stressful for patients. The critical care nurse is in an optimal position to reduce patients' stress during this process. The findings of this exploratory study suggest practice changes--based on patients' perspectives--that help reduce patients' feelings of uncertainty and stress as they are weaned from mechanical ventilation.

Adaptation, Psychological↗