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Biomedical subjects

A Perera

Publications and source records attributed to A Perera.

47 records · Page 3Linked to original sources
PubMed1987

Factors influencing the sensitivity of two human bladder carcinoma cell lines to cis-diamminedichloroplatinum(II).

A two-fold difference in sensitivity to cis-diamminedichloroplatinum(II) (cisplatin), as judged by colony forming assays, has been demonstrated in two human bladder carcinoma continuous cell lines. Approximately twice as many DNA-DNA interstrand cross-links (ISL) and a 2-fold greater inhibition of DNA synthesis occurred in the more sensitive T24 cell line than in the RT112 cell line after exposure to the same concentrations of cisplatin. Equitoxic concentrations of cisplatin resulted in similar extents of ISL and inhibition of DNA synthesis in both cell lines. Although drug uptake was identical, twice as much cisplatin was bound to the DNA of T24 cells than RT112 cells. However after equitoxic concentrations of cisplatin the DNA from both cell lines was platinated to a similar extent. In addition, levels of glutathione (GSH), glutathione reductase (GR) and total glutathione-S-transferases (GST) were higher in the less sensitive RT112 cell line.

Biological Transport↗
PubMed1982

Surgery for morbid obesity in a provincial centre.

Forty-eight patients underwent surgery for morbid obesity, 20 had gastric bypass and 28 had gastric partitioning or stapling. Gastric bypass was effective in producing satisfactory weight loss. There were few long term sequelae. However, it was complex and difficult technically, with a substantial mortality--three deaths. Gastric partitioning was simpler and safer, no mortality or serious complications but it was less reliable in producing satisfactory weight loss. Eleven patients showing no sign of getting within 20 percent of their ideal weight; this includes four with staple disruption. A small stomach syndrome is produced with transient qualitative limitation of overeating. A degree of motivation and dietary reform is necessary to produce the qualitative changes that the dumping symptoms, associated with gastric bypass, compel. Important features of management are careful selection and counselling pre operatively and regular follow up by both surgeon and dietitian.

Adult↗
PubMed1982

[Dysplasia epiphysialis hemimelica (author's transl)].

The first report of dysplasia epiphysialis hemimelica in the spanish literature is presented. The case has peculiar clinical features as the early presentation (two months) and to involve lower and upper extremities. On X-ray examination exostosis and calcium deposits were shown on the most affected epiphysis. Microscopically an osteochondroma, anomalous vascular channels, non hitherto described, were detected, as well as multivacuolated cells into them although ultrastructural and histochemical studies were carried on the precise nature of these cells could not be established. The possible pathogenetic significance of these findings is discussed.

Bone Diseases, Developmental↗
PubMed1982

[Mucoepidermoid tumour in an eight-year-old boy (author's transl)].

Report of a bronchial mucoepidermoid tumour, in a eight years old boy. This is the first report of this kind of tumour in the pediatric age in the Spanish literature. The clinical and radiological features are considered as well as the usefulness of endoscopy in the diagnosis of bronchial tumours in children. The pathologic findings, differential diagnosis and the surgical treatment performed are discussed. These tumours are of low grade malignancy with an excellent prognosis as is confirmed by the follow-up of the present case without recurrences or metastasis after nine years.

Adenoma↗
PubMed1982

[Seckel's syndrome: a form of chondrodysplasia? (author's transl)].

The true entity of Seckel's (bird headed dwarfism) has been hardly questioned due to the variety of malformations reported in these patients. However all cases reported have in common: dwarfism, bird head, microcephaly, mental retardation and malformations of different kinds. All these features must be present for the correct diagnosis. In two cases of Seckel's syndrome, full diagnostic features and post-mortem findings are reported. Special emphasis is made on the neuropathologic lesions. For the first time in the literature, changes in the epiphyseal tibial cartilage (with histochemical and EM studies) are described and correlated to dwarfism. Based on morphological data the authors propose Seckel syndrome as a condrodysplasia.

Abnormalities, Multiple↗
PubMed1982

[Lethal osteogenesis imperfecta. Anatomopathologic (optical and structural) study of 8 autopsy cases].

A pathologic review of lethal osteogenesis imperfecta was performed based in nine cases and mainly concerning eight cases with total postmortem study. One of the cases was classified as type III while all other were of type II. Emphasis is made on the high rate of prematurity, small for date and podalic presentation at birth. In those six cases of lower age lung hypoplasia was present. Well known findings in membranous or enchondral bones were confirmed in this series. Long bones showed characteristic bowings related to the nutrient artery point of entry. Among bone collagen fibres some of them were anomalous in shape or thickness but with normal striation. The only anomaly detected at the cartilaginous epiphysis was the increased wideness of the vascular channels because the existence of loose connective tissue and multivacuolated cells of unknown significance. At the growth plates the vascular channels were too much widened and of abnormal distribution. The proliferative and columnar zones showed poor cellular population and some condrocytes were abnormally vacuolated. The perichondrial ossification groove of Ranvier was absent or underdeveloped in all bones studied coexisting with epiphyseal-metaphyseal deformities. In our present cases, ocular, dental, dermal, cardiac valves and hepatic alterations have been detected. The weight increase and haematopoiesis of the liver was correlated to the hyperplasia and fibrosis of the bone marrow.

Bone and Bones↗
PubMed1974

[Not Available].

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History, Ancient↗
PubMedDate not supplied

[Late hereditary degenerative sensorineural hearing loss associated with IgA mesangial glomerulonephritis of probable autosomal dominant heredity].

We studied four generations of a Canary Islands family presenting a tardive heredodegenerative hearing loss, associated with IgA mesangial glomerulonephritis, of probable autosomal dominant heredity. With respect to the family, we revised Alport's syndrome, for possible transmission associated with X chromosome, as well as heredodegenerative hearing loss associated with renal pathology of autosomic transmission currently described; we differentiate these hearing losses from our case study, and we discuss the pathogeny of the auditive affection in the said hereditary syndromes. Lastly, we stress the autoimmune hypothesis because of the IgA nephropathy association in the family case, and we list the characteristics of the syndrome described.

Adolescent↗
PubMedDate not supplied

[Clinical characteristics and epidemiologic study of a listeriosis outbreak in Grand Canary].

BACKGROUND AND METHODS: Human infections caused by Listeria monocytogenes often present as sporadic cases without any epidemiological relationship among them; however they also appear as outbreaks that are usually detected by an increase in the number of cases diagnosed by hospitals of the geographic area. Between December 1991 and May 1993, twenty four cases of listeriosis were detected in three hospitals of Las Palmas de Gran Canaria; and they were classified as an outbreak. Our report describes its clinical, epidemiological and microbiological aspects. RESULTS AND CONCLUSIONS: Twenty four cases of listeriosis were diagnosed, 12 occurred in pregnant women or neonates (5 and 7 respectively) and 12 in non pregnant adults. All adult infections were community-acquired. The incidence rate was, for the epidemic area, 76.3 cases per million population during the period considered (18 months). Among non pregnant adults, 9/12 patients had some underlying disease and 9/12 presented CNS affection (meningitis and/or cerebritis). In the group of pregnant women, 4 cases occurred in the second trimester and fetal loss was caused; one case was detected in the third trimester and four weeks later the patient delivered an unaffected infant. All cases of neonatal listeriosis presented as early-onset sepsis. Of the 24 strains of L. monocytogenes, 21 were serotype 4, two were serotype 1 and one was not typeable. Strains from 12 patients were available for epidemiological analysis, seven of which corresponded to the same pattern and there were three more different patterns.

Abortion, Spontaneous↗