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Biomedical subjects

A Pecile

Publications and source records attributed to A Pecile.

At least 73 records · Page 4Linked to original sources
PubMed1977

Effect of halopredone acetate on rat liver tryptophan oxygenase and tyrosine aminotransferase activities.

The possible inductive effect of a new local antiinflammatory steroid, 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), on the rat liver enzymes tryptophan oxygenase and tyrosine aminotransferase was evaluated. The new steroid, when present in the implanted cotton-pellets or when s.c. injected, unlike the reference compound, fluocinolone acetonide, which induced a large increase in both enzymes, did not modify either tryptophan oxygenase or tyrosine aminotransferase. The results confirm that halopredone acetate elicits potent local antiinflammatory activity in the absence of systemic effects.

Administration, Topical↗
PubMed1977

Hypersensititivity of rats to anorectic agents after lesions in the ventromedial hypothalamus.

Anorectic agents such as d-amphetamine and fenfluramine showed a remarkably higher effect in rats with hyperphagia after lesioning the ventromedial hypothalamus. A persistence and even a further increase of the hypersensitivity to anorectics was observed in animals which, eight months after ventromedial hypothalamus-lesioning, resumed almost normal eating patterns. The appearance of the hypersensitivity to anorectic agents after lesioning and its persistence or enhancement in long-term operated animals are interpreted in terms of the mechanisms contributing to the neural reorganization of the control of the feeding center after suppression of ventromedial inhibitory influences.

Animals↗