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Biomedical subjects

A Patterson

Publications and source records attributed to A Patterson.

85 records · Page 5Linked to original sources
PubMedDate not supplied

Chemistry of cement burns: pathogenesis and treatment.

Two brief cases are presented describing burns resulting from exposure to cement and its components. Of particular interest is the etiology of such burns. Do they result from a high pH solution in contact with the skin under abrasive conditions for an undetermined period of time, or are they a consequence of possible allergic reactions to chromium or chromates? Another possible factor that has been largely unexplored is the role of the calcium ion--the other principal ionic species with which the skin is in contact. Much has been written about its role in membrane transport and other physiologic processes.

Adult↗
PubMedDate not supplied

Effects of low level dosing of iron on the haematology and growth rate of piglets.

Of 472 piglets (56 litters), half reeived 200 mg and half received 100 mg of iron as iron dextran administered intramuscularly as a single dose into the ham muscles between the first and fourth day after birth. The piglets were weaned at about three weeks of age, at which time those given 200 mg of iron had higher values of all haematological components. However, there was no significant difference between the mean daily live-weight gains of the two groups, and 100 mg iron maintained haematological components above levels associated with anaemia. It is suggested that 100 mg iron as iron dextran is adequate for piglets weaned at three weeks of age.

Animals↗
PubMedDate not supplied

Intermediate filament expression of ductal carcinoma cells in fine needle aspirates of the breast.

OBJECTIVE: To assess the frequency of occurrence of vimentin expression in fine needle aspirates of ductal carcinoma of the breast and the association of vimentin expression with established prognostic indicators. STUDY DESIGN: Cytocentrifuge preparations made from fine needle aspirates of 51 cases of ductal carcinoma were studied. RESULTS: Vimentin expression, detected in 61% of cases, was positively associated with tumor size, lymph node status, tumor grade, growth fraction and negative estrogen receptor status, but only in the case of lymph node status did the association reach the level of statistical significance. CONCLUSION: Vimentin expression can be detected in breast cancer using fine needle aspiration. Further study is necessary to determine whether it provides independent prognostic information.

Biopsy, Needle↗
PubMedDate not supplied

A comparative study--manual versus computerized automated drug delivery systems.

In this study, single-channel manual pumps were compared with multiple-channel computerized pumps with respect to specific nursing and pharmacy procedures. The nursing procedures include all the steps involved in taking care of a central line catheter, from verifying physician's orders, performing line changes, administering intermittent medications, and documenting fluids and medication infusions. The pharmacy procedures included assembling and priming the infusion sets. Nurses and pharmacy technicians were observed performing these functions, and a total of 358 timed observations were obtained. The data revealed a greater time savings with the computerized multiple-channel system when complex intravenous therapy is necessary.

Child↗
PubMedDate not supplied

Expression of intercellular and vascular cell adhesion molecules and class II major histocompatibility antigens in human lungs: lack of influence by conditions of organ preservation.

BACKGROUND: The expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and class II major histocompatibility complex antigens was studied in control lung tissue and preserved human donor lungs. The three controls were represented by wedge biopsy specimens taken from non-neoplastic lung surrounding bronchogenic carcinomas. METHODS: Nine lungs were harvested from six brain-dead donors, flushed with Euro-Collins solution or low potassium-dextran-glucose solution, and stored at 1 degree C or 10 degrees C. Samples of the latter organs were taken at the time of surgical harvest (baseline) and after 2, 12, 24, and 48 hours of preservation time. Immunostains with monoclonal antibodies against intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and class II major histocompatibility complex molecules were performed on all samples, and the relative presence of these determinants was evaluated. RESULTS: In both the controls and preserved lungs, intercellular adhesion molecule-1 expression was intense in the septal capillary endothelium and alveolar pneumocytes, but essentially absent in bronchial epithelium. Vascular cell adhesion molecule-1 was moderately to strongly labeled in the endothelia of large and small blood vessels of all types, and it was not seen in other cell types. Class II major histocompatibility complex antigens were variably observed in pulmonary epithelial cells, but they were not expressed by endothelia. There appeared to be no significant difference in the immunohistologic density of intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 immunostaining in allografts at the specified time points of preservation; this conclusion was confirmed by Western blot analysis. Similar findings pertained to staining results for human leukocyte DR antigens. There was likewise no significant difference in the expression of the three analytes when donor lungs perfused with Euro-Collins solution versus low potassium-dextran-glucose solution were compared; this was also true of organs preserved at 1 degree C versus 10 degrees C. CONCLUSIONS: These results suggest that, in the immediate post-harvest period, modulations in the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, or class II major histocompatibility complex antigens in pulmonary allografts are not attributable to the influences of preservation conditions.

Adolescent↗