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Biomedical subjects

A Passera

Publications and source records attributed to A Passera.

4 recordsLinked to original sources
PubMed1994

Ex vivo evaluation of pidotimod activity in patients with chronic obstructive pulmonary disease.

The aim of this study was to evaluate the activity of pidotimod ((R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxylic acid, PGT/1A, CAS 121808-62-6) on 52 patients affected with chronic obstructive pulmonary disease (COPD). The study was carried out in a randomized, parallel, double-blind trial, followed by incomplete blocks design. Pidotimod 800 mg was administered orally twice a day for 30 days. The follow-up period was 5 weeks. Our results show that in patients with COPD pidotimod potentiates T-cell activity. The effects on T-cells appear after 15 days of treatment and last for 5 weeks after the end of therapy. Since other studies demonstrated that pidotimod displays an immunopotentiating activity also on macrophages and granulocytes, the drug is useful to increase the immune defense during infections. The drug has a good compliance and is well tolerated also during long-term treatment.

Adjuvants, Immunologic↗
PubMed1985

[Chest pain].

After a thorough description of the physiological background, the problem of chest pain is examined with extensive documentation including pictures. It is suggested that meticulous clinical assessment is of even greater value than laboratory tests or instrumental explorations for the accurate diagnosis and appropriate treatment of the condition causing the pain. In other words laboratory and instrumental assessments should be based on and used to confirm an approximate diagnosis formed on clinical data.

Abdomen↗
PubMed1981

[A documented case of typical Hamman-Rich interstitial pulmonary fibrosis].

Following a brief mention of the classification of Hammer-Rich disease within idiopathic diffuse pulmonary fibrosis, the main clinical, radiological and laboratory features of these disease are outlined in brief. A personal case, subsequently controlled neroptically and histologically, is then described. From comparison between reported data and findings in the personal case, it is concluded that it was a typical, rare case (less than 150 others have so far been reported in all world literature) of Hamman-Rich disease. Other diagnostic hypotheses can be rejected because they are less correspondent to the typical picture and for various other considerations.

Cyanosis↗