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Biomedical subjects

A Papageorgiou

Publications and source records attributed to A Papageorgiou.

At least 91 records · Page 5Linked to original sources

[Satisfaction of couples towards birth when using a birthing room or the traditional delivery room.].

Following a random distribution, two groups of couples, users of the B.R. (birth room) and users of the T. R. (traditional room) were compared in terms of each partner's feeling of satisfaction in relation to the giving birth process. Statistical analysis of the means of the B.R. and T.R. fathers, of the B.R. and T.R. mothers, three days after delivery and three months later, yields the following results : following birth, both fathers and mothers of the B.R. group indicate a higher feeling of satisfaction than the T.R. mothers and fathers in relation to the environment. Mothers of the B.R. and T.R. are equally satisfied in relation to the amount of time spent with their infant, whereas fathers of the B. R. are more satisfied than their spouses and more satisfied than the T.R. fathers. Three months later, the only difference to these above-mentioned results, is the higher degree of satisfaction of B.R. mothers over T.R. mothers in relation to the length of contact with their infant right after birth.

English Abstract↗

Total-body protein turnover in human premature neonates: effects of birth weight, intra-uterine nutritional status and diet.

1. The effects of birth weight, intra-uterine nutritional status and protein and energy intake on whole-body protein turnover, and skeletal muscle protein breakdown were examined in 40 premature infants. 2. Total-body nitrogen flux was 26% higher in the small-for-gestational-age compared with appropriate-for-gestation-age infants; similarly, whole-body protein synthesis and breakdown were increased by 26 and 35% respectively (P less than 0.01). 3. The lower-birth-weight neonates (less than 1500 g) had higher rates of skeletal muscle protein breakdown; 1.23 +/- 1.12 g day-1 kg-1, as compared with 0.54 +/- 0.28 g for the high-birth-weight group (P less than 0.05). 4. Protein intake was inversely correlated with the fraction of nitrogen flux coming from endogenous protein breakdown (P less than 0.05) and with skeletal muscle protein breakdown (P less than 0.05). There were no significant relationships found between energy intake and the parameters of protein metabolism. 5. On the basis of the turnover data, evidence is presented that the protein requirements for milk-protein fed premature neonates is less than 4.3 g day-1 kg-1.

Birth Weight↗

New compounds: antitumor activity of 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate.

3beta-Hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p[bis(2chloroethyl)amino]phenyl]butyrate was prepared by reacting 4-[p-[bis(2-chloroethyl)amino]phenyl]butyryl chloride hydrochloride with 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam. They cytostatic action of the ester was investigated on two tumor systems (B16 melanoma on C57 b1 mice and T8-Guerin on rats).

Animals↗

A familial syndrome of cranial, facial, oral and limb anomalies.

A family is described in which two male infants have microcephaly, abnormal ears, anti-mongoloid slant, small mouth, cleft palate, flexed overlapping fingers with syndactyly of digits three and four, syndactyly of the second to the fifth toes, and normal karyotype. This seems to be a new syndrome.

Abnormalities, Multiple↗

Klebsiella pneumonia with pneumatocele formation in a newborn infant.

The case of a premature infant with bacteriologically proved klebsiella pneumonia in the first week of life is reported. The clinical course was complicated by the early formation of pneumatoceles and subsequent recurrent pneumothoraces. Treatment consisted of antibiotic therapy and chest tube drainage. Satisfactory clinical recovery, growth and psychomotor development were noted at 1 year of age, despite the persistence of a pneumatocele in the right lung.

Carbenicillin↗

Reye's syndrome in a newborn infant.

A case of Reye's syndrome in a newborn infant, believed to be the first recorded in the perinatal period, is reported. The clinical, biochemical and histological findings are those previously recognized in older infants. The intractable acidosis, hypoglycemia and extreme degree of lactic acidosis reflect an advanced degree of hepatic involvement, probably initiated in utero, with resultant impairment of glycogenolysis and intermediary metabolism.

Acidosis↗

Antineoplastic and cytogenetic effects of platinum(II) and palladium(II) complexes with pyridine-2-carboxyaldehyde-thiosemicarbazone.

The effect of six novel complexes of Pt(II) and Pd(II) with pyridine-2-carboxyaldehyde thiosemicarbazone (HPyTsc) on sister chromatid exchange rate and human lymphocyte proliferation kinetic was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing cytogenetic and antineoplastic effects are the complexes [Pd(PyTsc)2] and [Pt(PyTsc)2]. Next in order of magnitude in inducing antineoplastic and cytogenetic effects is the compound [Pt(HPyTsc)2]Cl2 while the rest, i.e. [Pd(PyTsc)Cl], HPyTsc, [Pd(HPyTsc)2]Cl2, and [Pt(PyTsc)Cl], show marginal cytogenetic and antineoplastic effects.

Animals↗

Enhanced cytogenetic and antineoplastic effects by the combined action of two esteric steroidal derivatives of nitrogen mustards.

The authors studied the effect of two modified steroids containing different proportions (%) of alkylating agents alone or in combination on sister chromatid exchange (SCE) rates and on human lymphocyte proliferation kinetics. The antitumor activity of these compounds was tested on leukemia P388- and leukemia L1210-bearing mice. The two chemicals in mixtures enhance SCE induction and antitumor activity in a synergistic manner. The homo-aza-steroidal ester of p-bis(2-chloroethyl)aminophenyl acetic acid was found to be more effective than the homo-aza-steroidal ester of o-bis(2-chloroethyl)aminobenzoic acid in causing cytogenetic damage and antineoplastic activity. A correlation was observed between the magnitude of the SCE response and the depression of the cell proliferation index. The order of the antitumor effectiveness of the five different treatments tested coincided with the order of the cytogenetic effects they induced.

Animals↗

Effect of navelbine on inhibition of tumor growth, cellular differentiation and estrogen receptor status on Lewis lung carcinoma.

We studied the antitumor activity of Navelbine (NVB) together with its ability to induce cellular differentiation and to influence estrogen receptor status of Lewis lung carcinoma (LLC). A total of 32 C(57)B1 mice divided into 5 groups were used for transplantation of LLC. Four groups of mice were treated with 5.0, 2.5 and 1.25 mg/kg/day from day 1 to 9 and 1.25 mg/kg on days 1, 7 and 13. Eight mice were controls. The dose of 1.25 mg/kg/day was the most effective and produced 72.7% inhibition of tumor growth. Ultrastructurally, on day 1 the cells showed poor differentiation. On day 14, in the case of 72.7% inhibition of tumor growth the study revealed a significant restoration of the morphology of the cells. Estrogen receptors gave a positive value in contrast to the initial measurement which was negative. The present study demonstrated good antitumor activity of NVB on LLC. NVB may also induce cellular differentiation and influence the estrogen receptor status.

Animals↗