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Biomedical subjects

A Panasiuk

Publications and source records attributed to A Panasiuk.

At least 19 recordsLinked to original sources
PubMed1999

Efficacy of interferon therapy on patients with HCV infection in dependence from the time of treatment.

Among 45 patients with chronic hepatitis C the efficiency of interferon alpha 2b treatment was evaluated. The efficiency of interferon therapy was determined after 6 months of treatment in the group of 28 patients (group I) treated for 6 months and 17 patients (group II) treated for 12 months. The side effects were investigated with respect to such a factor as time of treatment. 11 (39%) patients from group I had eliminated HCV RNA and 14 (50%) patients had normalized AlAT levels in the serum. Five (29%) patients from group II eliminated HCV RNA and 8 (47%) patients had normalized AlAT levels in the serum. The flu-like syndrome, thrombocytopenia, vision disorder, depression and somnolence were most often the side effects observed in treated patients. Proportionally to time of treatment vision disorder, depression and somnolence increased.

Adult↗
PubMed1998

Estimation of platelet function state in the course of trichinella spiralis infection.

Platelets are part of body defence system, especially the antiparasite immunologic response. Platelets manifest their functions only after their activation. Thrombin activates platelets inducing change of their shape and causing secretion of certain substances. This study was designed to estimate blood platelets morphology as an indicator of their activation and effectiveness of antiparasite therapy. The study was conducted in group of 21 patients infected with T.spiralis before treatment (T1) and group of 19 patients after two weeks of treatment (T2). The diagnosis of trichinellosis was established on the bases of epidemiologic history, clinical picture and immunologic investigations. In the course of trichinellosis and after antiparasitic treatment increase of blood platelet count was observed. The decreased mean platelets volume observed in trichinellosis may be connected with their activation and releasing platelet factor 4 and beta-thromboglobulin. We suggest that T.spiralis activates platelets and the degree of their activation determines their morphologic parameters.

Adolescent↗
PubMed1997

[Snake bites].

Vipera berus is the only viper i.e. venomous (poisonous) snake that is found in Poland. Snakebites occur rarely und usually follow attempts of catching the viper or accidental treading on it. Appropriate treatment consists of administering specific antivenom serum (antivenin). Four cases of snakebites hospitalized in 1989-1995 in the Department of Infectious Diseases of the University Medical School in Białystok are reported.

Adult↗
PubMed1997

Does the concentration of alpha 1-proteinase inhibitor reflect the transformation of liver cirrhosis to liver carcinoma?

Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in HCC by 29%. The level of alpha1-PI higher than (220 mg%) may be indicative of the disease progression towards decompensated LC or HCC. In the conclusion, an increase in alpha1-PI concentration in patients with LC may be considered as an alarming factor, but is not sufficiently specific to become a diagnostic tool for the detection of HCC development.

Adult↗
PubMed1997

Alcohol dehydrogenase (ADH) activity in the sera of patients during the course of viral hepatitis.

Total alcohol dehydrogenase activity in the sera of 77 patients in the course of viral hepatitis was determined by means of photometric method based on p-nitrosodimethylaniline reduction. Blood samples were taken 5 times at intervals of 7 to 9 day. We found that serum total ADH activity was higher at the onset of disease than that of the control group. The highest increase of activity was observed in the first week of hospitalisation, and exceeded the mean control value about 7 times. After that, the activity of ADH gradually decreased, and reached the value of the control group in the last period of the study. During five weeks of the study the total activity of ADH showed a good linear correlation with alanine and aspartate aminotransferases. We concluded that total alcohol dehydrogenase activity measured by photometric method increase in the course of viral hepatitis and correlate with the progress and treatment of disease measured by commonly accepted enzymatic markers of liver cell damage.

Adolescent↗
PubMed1997

The bactericidal activity of blood platelets in patients infested with Entamoeba histolytica/Entamoeba dispar.

Blood platelets participate actively in organism defensive reactions and particularity in antiparasitic immunity. Platelets stimulation can be the result of contact with a parasite, the presence of immunoglobulins, complement and lymphokines. The aim of the study was to evaluate the blood platelets bactericidal activity in the course of amoebiasis. The examination was carried out in the group of 22 patients with E. histolytica/E. dispar, diagnosed on the basis of cyst forms presence in faeces. The results show that blood platelets bactericidal activity is significantly impaired in the course of amoebiasis.

Adolescent↗
PubMed1996

Does anti-parasitic treatment normalize platelets morphology in patients infested with Entamoeba histolytica?

Platelets are part of body defence system, especially the anti-parasite immunologic response. Platelets manifest their functions only after their activation. Thrombine activates platelets inducing change of their shape and causing secretion of certain substances. This study was designed to estimate platelet morphology as an indicator of their activation and effectiveness of anti-parasite therapy. The study was conducted in group of 30 patients infested with E. histolytica before treatment (A) and group of 23 patients after 2-week treatment course (B). The diagnosis of amoebiasis was based on detection of cyst forms in faeces. During the course of amoebiasis increase of platelets count and platelet crit (PCT) was observed. Mean platelet volume (MPV) in both groups (A and B) was decreased as compared with control group. We suggest that E. histolytica activates platelets, and the degree of their activation determines their morphologic parameters, and these changes come back to normal values during anti-parasite treatment.

Adult↗
PubMed1996

Human serum alcohol dehydrogenase isoenzymes as a markers of liver injury during viral hepatitis.

We examined the activity of class I and II of alcohol dehydrogenase isoenzymes in the sera of patients with viral hepatitis using fluorogenic substrates, 4-methoxy-1-naphthaldehyde for class I and 6-methoxy-2-naphthaldehyde for class II. It was found that serum activities of class I and II of alcohol dehydrogenase isoenzymes during five weeks of hospitalisation were higher than that of control. The greatest increase in activities was found at the onset of disease, and exceeded the mean control value about 30 times for class I and 4 times for class II. These were lower than the aminotransferase activities but higher than the activity of lactate dehydrogenase, alkaline phosphatase and gamma-glutamyltransferase. In the following periods of investigation the activity of alcohol dehydrogenase isoenzymes gradually decreased, but did not reach the values of the control groups in the last period of the study. Activity of class I and II of alcohol dehydrogenase isoenzymes showed a good correlation with alanine and aspartate aminotransferase and lactate dehydrogenase in the first weeks of the illness. These results clearly demonstrate that particularly the activity of class I of alcohol dehydrogenase isoenzymes measured by a fluorimetric method can be a useful marker of liver cell damage in the course of viral hepatitis.

Adolescent↗
PubMed1996

[Phagocytic activity of blood platelets in patients infected with Giardia intestinalis].

Blood platelets take part in immune reactions of the organism, especially in anti-parasitic immunity. We conducted this study measuring the phagocytic activity of blood platelets. The experiments were done on 35 patients infected G. intestinalis. Diagnosis was supported on finding trophozoits in bile cysts and GSA-65 protein in feces. We have found some decrease of blood platelets count and the increase the percentage of phagocytic platelets. Our general conclusion is, the parasite is able to stimulate the phagocytic activity of blood platelets.

Adult↗
PubMed1996

[Multiorgan changes in AIDS in a reported case].

The clinical course of HIV infection and results of autopsy examination in 49 years old patient was shown. The attention was paid to difficulties of diagnosis of opportunistic infections in a patients with advanced HIV disease. Variety of infectious factors, that could affect a patient with significant immunodeficiency was outlined.

AIDS-Related Opportunistic Infections↗
PubMed1995

The assessment of functional status of blood platelets in patients infected with Giardia intestinalis after anti-parasitic treatment.

Platelets are involved in anti-parasitic mechanisms. This question is poorly recognized. Platelets may exhibit this function only after activation. Therefore we conducted this study measuring some morphological parameters of these cells which reflect activation of platelets. The experiments were done on 30 patients infected with Giardia intestinalis. Diagnosis was supported on finding trophozoits in bile, cysts and GSA 65-protein in feces. We have found some decrease of blood platelets count and normalization after anti-parasitic treatment. In the line with this observation is platelet crit. A slight change was noted in mean platelet volume before and after treatment if we compare to controls. The same observation concern platelet anisocytosis index. Nearly two-fold decrease in the count of large platelets was observed before and after treatment 3.77% and 2.07%. Our general conclusion is, the parasite is able to activate the platelets and anti-parasitic treatment normalize these changes.

Adolescent↗
PubMed1993

[Pulmonary thromboembolism--random analysis of autopsy material].

In the study an analysis of 13216 autopsy materials was performed to evaluate a frequency of pulmonary thromboembolism incidence including localisation of detected changes. Pulmonary thromboembolism was determined in 5.5% autopsies, with evident increase in older subjects (up to 31.3% in 70-79 years old group). The most frequently (67.8%) pulmonary thromboembolism was observed in lobar and segmental arteries in a course of atherosclerosis (28.6%), neoplasmas (20.8%) and septic diseases (15.5%). In 25% cases of pulmonary thromboembolism has been diagnosed during clinical observations and has been confirmed by autopsy procedure.

Adolescent↗
PubMed1992

[Appendicitis and its atypical causes].

The authors analysed 2849 patients who were admitted to the Department of General Surgery, Regional Hospital in Pisz in the years 1980-1989 with symptoms suggestive of appendicitis. In 983 cases surgical intervention was abandoned, because the symptoms regressed spontaneously or were caused by diseases of other organs. The pathological conditions associated with appendicitis are analysed in 1866 surgically treated patients. Cases of appendicitis caused by Oxyuris vermicularis, Salmonella-enteritidis and actinomycosis (one case each) and appendicular carcinoma (2 cases) are described in more detail. Attention is called to the aetiology, pathogenesis and treatment of these rare causes of appendicitis.

Actinomycosis↗
PubMed1991

[Morphological changes of bone marrow in patients with bronchial and gastrointestinal carcinoma and hematological abnormalities in peripheral blood].

The authors carried out the morphological and clinical analysis of 200 cases patients suffering from carcinoma but not treated (104 cases of carcinoma of the bronchus, 30 cases of the stomach, 26 cases of the pancreas, 24 cases of the liver and gallbladder and 16 cases of the large intestine) and have estimated the hematological and bone marrow abnormalities. Most frequently occurring hematological changes in this group were: anaemia (28.5%), thrombocytopenia (22.4%), clinical symptoms of thrombosis (22.0%) and changes of bone marrow: sclerosis (42.5%), neoplastic metastases (30.0%), and atrophy (27.5%). In the examined cases the authors have not found any particular connection between the kind of hematological abnormalities and the kind of morphological changes of the bone marrow. The most common changes in the bone marrow which accompanied hematological abnormalities were neoplastic metastases and atrophy of the marrow especially in cases with anaemia and thrombocytopenia.

Adult↗
PubMed1991

[Epidemiology of intra-marital infections with hepatitis B virus (HBV) among the patients hospitalized in the infectious disease clinics in the Białystok region 1988-1990].

Viral hepatitis B infection is worldwide epidemiological and clinical problem with same prophylactic difficulties concerned first of all married patients. The infection routes could be parenteral or homo/heterosexual contact. During 1988-1990 from hospitalized viral hepatitis B all patients (394), married patients was found 9% (34) persons with epidemiological documented viral hepatitis B infection, from his/her sexual married partner.

Adult↗
PubMed1989

[The NBT test in bacterial infections complicating prednisone-treated nephrotic syndrome].

The spontaneous nitroblue tetrazolium reduction test was done in children with nephrotic syndrome treated with prednisone and with secondary bacterial infections and in children with urinary tract infections not treated with prednisone. In healthy children 9.0 +/- 1.3% of polymorphonuclear leucocytes in peripheral blood showed presence of deposits in the NBT test. In children not treated with prednisone the number of NBT (+) leucocytes was increased over fourfold. The value of the NBT test was highest at the beginning of the disease. In children treated with prednisone the value of the NBT test increased slowly. The highest results were obtained in the second week of infection treatment. In relation to controls the proportion of NBT (+) test in peripheral blood was increased threefold.

Bacterial Infections↗
PubMed1980

[L. A. Tarasevich].

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History, 19th Century↗