Biomedical subjects

A Pakkanen

Publications and source records attributed to A Pakkanen.

22 records · Page 2Linked to original sources

PubMed1980

The use of labetalol as a moderate hypotensive agent in otological operations--plasma concentrations after intravenous administration.

The usefulness of labetalol, a combined alpha and beta adrenoceptor antagonist, as a moderate hypotensive agent during combination anaesthesia in otological operations was studied. These preliminary results show that an intravenous dose of 2.0 mg/kg of body weight of labetalol causes a moderate decrease in blood pressure without a concomitant increase in heart rate or excessive hypotension. The half-life of the elimination phase of labetalol in plasma varied between 3.9 and 6.3 hours. A direct relationship between the intravenous dose of the drug (0.5, 1.0 and 2.0 mg/kg i.v.) and the increase in the AUC value was observed. No correlation was found between the decrease in either the systolic or diastolic blood pressure and the plasma level of labetalol. This new type of antagonist may possess advantages over other current hypotensive drugs, i.e lack of tachycardia and excessive hypotension.

Adult↗

PubMed1979

Labetalol as a hypotensive agent in otological operations.

The usefulness of labetalol, a new combined alpha and beta adrenoceptor antagonist as a hypotensive agent in otological operations was studied in 18 otherwise healthy patients. After a single 1.0 mg/kg i.v. dose the maximum decrease in systolic (18%) and diastolic (8%) blood pressure occured between 5 to 15 minutes (mean 11 min), and the pretreatment blood pressure values were reached in 15 to 55 min (mean 26 min). Similarly, after a single 2.0 mg/kg i.v. dose the maximum blood pressure decrease (32%/20%) was observed in 5 to 40 minutes (mean 23.5 min) lasting 30 to 95 minutes (mean 60.1 min). Generally, a moderate decrease in blood pressure without a concomitant increase in heart rate or excessive hypotension was found.

Adrenergic alpha-Antagonists↗

PubMed1977

Burn injuries in Finland.

In the present investigation the burn injuries in Finland are estimated for a non-selected burns population. Annually 0.4% of the population seek medical care for burn injuries. The incidence of burns cases requiring hospital admission is 35/10(5) inhabitants/year. After initial treatment in the emergency ward, approximately 10% of burned adults and up to 25% of burned children are hospitalized. Of all burns cases requiring hospitalization, 55% are children under 15, 40% are adults of working age and only 5% are over 65 years of age. Men comprise two-thirds of the patients. The estimated bed capacity according to data collected is 20 per one million inhabitants (16 in the case of a continuous 100% load): 12 for adults and 8 for children. Of all the fatalities from burns, approximately 70% of deaths occur immediately from injury. The overall hospital mortality of burned adults is 5%, and 1% in children. The most typical burned child is a toddler with a burn covering less than 5% of the skin surface. The average burned adult in hospital is a man of 42 with 12% burn of total skin surface (3% of third degree) and who is discharged after 17 days of hospitalization.

Adolescent↗

PubMedDate not supplied

Individual alcohol reaction profiles.

The purpose of this study was to evaluate interindividual variation in acute reactions to ethanol. Six young, healthy female subjects participated in a double-blind experiment consisting of two identical alcohol sessions and one control session where glucose was infused instead of ethanol. Alcohol was infused in a standardized way to reach blood alcohol concentration of 1 mg/ml in 1 hr. During the 4 hr-sessions EEG-spectra, smooth pursuit eye movements, various mood variables, BAC and breath alcohol concentrations were studied repeatedly. The results showed that the subjects had a rather repeatable, individual reaction profile as expressed by changes in alpha mean frequency, theta band power, amount of corrective eye movements and subjective intoxication. The sensitivity of the subject to ethanol should thus be expressed as a reaction profile rather than as a change in a single variable.

Adult↗