Search PubMed⌕ Search

Biomedical subjects

A Pagani

Publications and source records attributed to A Pagani.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Preprandial and postprandial variations of insulin sensitivity in different times of the day assessed by the artificial pancreas in type I diabetics.

The aim of this study is to see whether changes in insulin need and in sensitivity to exogenous insulin occur in insulin-dependent diabetics receiving 3 daily non-isocaloric meals (at 0630, 1200 and 1730). In 9 type I diabetics submitted to the artificial pancreas control the insulin administered/dietary carbohydrates index (I/C) after breakfast (2.4 +/- 0.5) was significantly higher than after lunch (0.8 +/- 0.1) and after supper (0.84 +/- 0.1) (p less than 0.01). A trend to the reduced insulin sensitivity in the morning was also observed in fasting periods, when it was calculated as the ratio between blood glucose and insulin administered (BG/I): differences of BG/I however were not significant. It was concluded that diurnal variations of insulin sensitivity do occur in type I diabetic subjects, with an increment of insulin requirement in the morning.

Blood Glucose↗
PubMedDate not supplied

Refractory thrombotic thrombocytopenic purpura: successful treatment by plasmapheresis with plasma cryosupernatant.

BACKGROUND: Plasma exchange (PE) with reinfusion of fresh frozen plasma (FFP) is the therapy of choice for thrombotic thrombocytopenic purpura (TTP) in the acute phase. About 20% of patients do not respond fully to this treatment and can suffer relapse. The plasma cryosupernatant (PCS) fraction depleted of the largest von Willebrand factor (vWF) multimers, considered to be among the possible causes of relapse, has recently been suggested as an alternative to FFP. METHODS: We submitted three patients in TTP relapse to plasma exchange with reinfusion of PCS. This treatment was associated with anti-platelet agents in two of the patients. RESULTS: Infusion of PCS led to a rapid improvement of the clinical picture in all three patients, with a return to normal of the reference parameters (platelet count' serum LDH). A few days after suspending PE, the patient not receiving anti-platelet treatment suffered another relapse which was definitively resolved with resumption of PE and administration of anti-platelet agents. CONCLUSIONS: We consider PCS to be a valid alternative treatment for TTP relapses, and we have found that the best results are obtained when it is associated with anti-platelet agents.

Adult↗