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Biomedical subjects

A P Surguchev

Publications and source records attributed to A P Surguchev.

At least 19 recordsLinked to original sources
PubMed1990

[Restriction polymorphism in patients with lipid metabolism disorders and ischemic heart disease].

Using the RELP analysis we studied the frequency of X2 allele of apoB gene in three groups of patients: 1) men at the age of 20-59 with lipid metabolism disorders revealed in population inspection of Oktyabrsky district in Moscow; 2) men with ischaemic heart disease and 3) healthy men. It was established that in individuals suffering from type IIa hyperlipidemia the frequency of X2 allele was significantly higher than in healthy donors from Moscow population. Homozygotes for X2 allele of XbaI RELP had 7-9% higher serum cholesterol levels, than homozygotes for X1 allele. The study suggests the X2 allele of the apoB gene to be associated with the development of high plasma cholesterol level. No significant difference in X2 allele frequencies was found between patients with ischaemic heart disease and healthy donors. There was also no association found between cholesterol and triglyceride levels and the presence of X2 allele in this group of patients.

Adult↗
PubMed1988

[Nuclear and mitochondrial genes in the biogenesis of Saccharomyces cerevisiae mitochondria].

The mechanisms of interaction of nuclear and mitochondrial genes in biogenesis of mitochondria are discussed in this review. Brief characterization of yeast mitochondrial genes and their products is presented. The mechanism of nuclear and mitochondrial control of expression of the mosaic genes in mitochondria is described. The data on the processing of imported mitochondrial proteins synthesized on cytoplasmic ribosomes are presented. The possibility of existence of common proteins encoded for by common genes and possessing similar functions in the cytoplasm and mitochondria is discussed. A hypothesis is put forward considering the role of common proteins in coordination of nuclear and mitochondrial genes' expression in biogenesis of mitochondria.

DNA, Fungal↗
PubMedDate not supplied

[Polymorphism of human genes, methods of its detection and relation with cardiovascular diseases (review of the literature)].

The data on human gene polymorphism in connection to cardiovascular diseases are reviewed. Special attention is paid to the genes encoding apolipoproteins, the components of lipoprotein particles that play an important role in lipid transport and metabolism. Besides, the data on polymorphic forms of genes, encoding LDL-receptor, enzymes, participating in lipid metabolism and other genes relevant to the development of certain pathologies of cardiovascular system are presented. Possibilities of use of the information on the gene polymorphism for diagnostic purposes and for understanding the molecular mechanisms of the disease are discussed.

Cardiovascular Diseases↗
PubMedDate not supplied

[Nucleotide sequence of a mutant allele and wild type allele SUP1 and comparison of transcripts of SUP1 and SUP2 genes].

Nucleotide sequences of the yeast recessive suppressor gene SUP1 and one of its mutant alleles (supl-ts36) are compared. One open reading frame is found in the gene able to code 438 amino acid residues. The reading frame is not interrupted by introns. Mutant allele supl-ts36 contains one nucleotide change at position + 101 (T----C) inducing the exchange of leucine on serine in N-terminal part of the polypeptide product. The homology between the structure of SUP1 gene and two groups of proteins is found (1.tRNA-binding or nucleotide-binding proteins; 2. mitochondrial proteins coded by mitochondrial genome). The size of transcript for SUP1 gene is 1600 nucleotides corresponding to the coding region of the gene. For SUP2 gene two stable transcripts are found corresponding to approximately 2500 and approximately 1400 nucleotides. The homology between SUP1 and SUP2 genes is not found. The absence of splicing for both SUP1 and SUP2 genes transcripts is demonstrated in the experiments with RNA2 conditional mutants with impaired splicing.

Alleles↗