Biomedical subjects
Publications and source records attributed to A P Romodanov.
In the late period even following mild closed brain injury, diseases of the viscera and the body's systems develop as a result of diffuse lesions in the brain regions. Experimental studies have shown that this is associated with impaired self-regulatory mechanisms responsible for energy metabolic processes in the brain.
Antitumour activity of cerebral cells at different stages of ontogenesis (embryonic, new-born, adult) has been studied. Researches have been carried out at killer-activity patterns in vitro with target-cells and tumour transplantation under mice kidney's capsule in vivo. It has been established that mice cerebral cells' suspension can decrease the tumour transplants' growth under kidney's capsule. Antiproliferative activity of embryonic and new-born mice cerebral cells was much higher than adult one. The kidney and liver new-born mice cells had no antiproliferative activity at all.
The study was made of correlations arising between psychopathological symptoms (PPS) observed in organic brain lesions in acute posttraumatic, postoperative and posthemorrhagic periods in 111 patients with objective data on cerebral circulation and cerebrovascular reactivity (CVR). PPS included mental conditions of delirium type: of classical form (106 cases), of atypical forms (5 cases). In PPS there appeared a tendency to an increase in the values of cerebral circulation and CVR. PPS patterns and regions of elevated CVR were found related. Long-term persistence of PPS in the acute disease eventuated into a reduction of psychic functions and total and regional hemodynamics. In atypical delirium against preexisting encephalopathy the trend to hyperreactivity of the brain vessels disappeared during a short period.
It is indicated that all subjects who had acute grade I radiation sickness of the Chernobyl accident showed disorders of the brain functions 5-6 years later. They evidence involvement of all brain structures but especially the subcortical brainstem portions. Marked memory reduction was also noted. The neurological deficit was not pronounced but the patients developed a syndrome of significant disadaptation, which had a progressive character. The authors propose to term these changes as postradiation encephalopathy of primary-radiation and intoxication genesis.
The paper concerns the results of 30 years of investigations of the Kiev Research Institute of Neurosurgery into correlations between syndromes of mental activity reduction (coma, stupor, global and lacunar dementias, Alzheimer-like and Pick-like syndromes, personality changes by the frontal type, stable neurosis-like conditions, Korsakov's syndrome, disturbed consciousness by the amentive type) in patients with organic brain lesions and objectively recordable changes in cerebral hemodynamics. It has been established that the pathological mechanisms of formation of different syndromes of mental activity reduction are naturally related to deceleration of the general and regional volumetric cerebral blood flow (RVCBF) and a decrease of the general and regional reaction of cerebral vessels (RCV). In this respect, the character of the psychopathological syndrome is specified by localization (lobar and interhemispheric) of the primary deceleration of the RVCBF and RCV decrease; by the rate of augmentation of those changes, their intensity and duration, constancy or periodicity; background against which there develops the hypoxic process; as well as by the development of the underlying disease.
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The article presents some data concerning influence of humoral factor received from blood serum of injured animals on humoral and cell immune response of animals. The results show that administration of humoral factor prevents stress-induced devastation of thymus, improves humoral immune response to antigen test (sheep erythrocytes) and restores hypersensitivity of decelerated type (HDT) reactions. Immune stimulating effects are observed both right after cranial trauma and some time later -- 5-7 days after the injury.
Subdural hematomas were evacuated in 41 newborns during the first 4 days after birth. Subdural hematomas due to birth trauma may be subdivided into supratentorial, subtentorial, and suprasubtentorial. The location was frequently bilateral. The clinical course and diagnosis are described. Evacuation of the subdural hematoma was performed by subdural taps, linear craniotomies through the coronal and lambdoid sutures, and, in some cases, by combined approaches. The results were favorable in 68.3% of cases.
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