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Biomedical subjects

A P Petrov

Publications and source records attributed to A P Petrov.

At least 19 recordsLinked to original sources
PubMed1991

[Cavinton in the prevention of the convulsive syndrome in children after birth injury].

The authors studied the efficacy of cavinton as an agent helpful in preventing neurologic disorders in the newborn with hypoxic ischemic encephalopathy due to intracranial birth trauma. The short-term results of the treatment were elucidated in 61 children. In group I including 20 persons given conventional therapy, the disappearance of seizures was recorded in 6 patients; out of 41 children (group II) given additionally cavinton, in 27. Twenty-nine children were followed up for a year. In group I, convulsive paroxysms recurred in 4 patients, whereas in the group II children, no convulsive syndrome was recorded on the follow-up. The group II children also showed a decrease of the phenomena of intracranial hypertension and normalization of the psychomotor development. The preventive effect of cavinton seen in children with a history of birth trauma may be accounted for by its capacity of normalizing cerebrovascular disorders and by its own anticonvulsive properties.

Anticonvulsants↗
PubMed1986

[Use of cavinton in epilepsy].

The authors studied the effect of cavinton (15-45 mg/day) and its combinations with different anticonvulsants on the time-course of different forms of epilepsy. In 20 of the 31 patients studied treatment with cavinton either significantly decreased the frequency of attacks or led to their complete disappearance; in 7 patients the improvement was insignificant and in 4 the condition deteriorated. The greatest effect of cavinton was observed in generalized tonic-clonic convulsions and when they were combined with absences. Clinical improvement not always correlated with EEG normalization. A suggestion is made that the mechanism of the anticonvulsive action of cavinton may be explained both by the normalization of the cerebral blood flow and elimination of hypoxia and by the fact that the drug may possess anticonvulsive properties unrelated to the normalization of the cerebral hemodynamics.

Adolescent↗
PubMed1976

[Torsional movements of the human eye. II. Slow phase of torsion].

At different experimental conditions quantitative characteristics of the slow phase of the torsional eye movements were investigated. We found the torsional drift to increase when the head tilted faster and its velocity was bigger in the dark than in the light. Asymmetry of the drift velocity was found on moving the head to and backward. It was shown that the sign of the asymmetry did not depend on rotatory movements of the cup (the suction device for eye movement registration). At the same time electric stimulation of the labyrinth changed the sign of asymmetry and without head tilting led to the torsional eye movements (nistagmus). Some subjects were able to decline the number of the torsional saccades at will, and as a result the eye made a drift up to tens of degrees long. Possible causes of imperfect vestibular and optokinetic compensation in the eye trosion were discussed.

Ear, Inner↗
PubMed1976

[Change in aldosterone secretion by the adrenals and in its urinary excretion in rats under the action of acid polysaccharides].

Repeated administration of chondroitin sulfate to rats in doses of 20 and 120 mg/kg/24 hours led to reduction in the level of urinary aldosterone excretion in rats. Carboxymethylcellulose and alginic acid displayed no inhibitory effect. Urinary aldosterone excretion decreased in rats 24 hours after a single administration of chondroitin sulfate; this effect persisted for the following 3-4 days. The maximal reduction of aldosterone excretion (by 50%) occurred on the 3rd and the 4th day after administration of the preparation. Intraperitoneal injection of chondroitin sulfate to rats diminished the rate of aldosterone secretion by the adrenal glands; as to corticosterone secretion--it remained unchanged.

Adrenal Glands↗
PubMedDate not supplied

[Meiosis in Pleurotus florida Fovose].

It is stated that the meiosis of Pleurotus florida differs from the classical one. The condensation chromosomes conjugate in metaphase I.

Chromosomes, Fungal↗
PubMedDate not supplied

[Experimental verification of several assumptions and methods of statistical genetics. II].

The applicability of A. S. Serebrovsky's formulas and N. A. Sobolev's methods was investigated for a dihybrid cross. It was shown that Serebrovsky's formulas do not always lead to a correct estimation of the minimal number of genes by which the parents are distinguished. In the case of gene interaction this estimation sometimes proved to be exaggerated 2-4 times. A test of Sobolev's method demonstrated that this method cannot be considered as reliable for work. Most of his estimations are not correct. Various estimations of the same phenomenon are often contradictory.

Alleles↗
PubMedDate not supplied

[Effect of Cavinton on convulsions caused by chemical substances].

Cavinton was shown to protect mice against convulsions induced by corazol, strychnine and thiosemicarbazide. In addition, cavinton exhibited a definite antagonism to convulsive reactions produced by systemic administration of penicillin to cats and a combined administration of penicillin (intramuscularly) with tryptophan metabolite, quinolinic acid (intracerebroventricularly). The anticonvulsant action of cavinton is suggested to be due to the involvement of the brain GABA- and serotonergic mechanisms. It is reasonable to test cavinton as a drug for treating some forms of epilepsy.

Animals↗