Search PubMed⌕ Search

Biomedical subjects

A P Kulaichev

Publications and source records attributed to A P Kulaichev.

10 recordsLinked to original sources
PubMed1989

[Automation of research on memory using computers].

The article discusses the direction of integrated automation in memory investigations on the basis of hardware-software conveyor consisting of three interacting polyfunctional systems. All the systems are characterized by flexibility, accessibility and efficiency for memory investigations on the behavioral, macro- and microphysiological levels.

Animals↗
PubMed1987

[A multifunctional system for automating physiological experiments].

The methodical problems of automatization of physiological investigations on the basis of modern computer complexes "micro-CAMAC-lab" are discussed. The considered conceptions are illustrated by example of CAMEX-program-system ensuring the measurement, storing, visual control, editing and analysis of physiological experimental data.

Animals↗
PubMedDate not supplied

Functional characteristics of the mature and developing brain following neuroimmunization: analysis of short-term plasticity in the rat hippocampus.

The influence of neuroimmunization by the total antigens of the cytosol fraction of hippocampal tissue or neocortical tissue on the indices of short-term plasticity in adult and developing (3 to 4 week old) Wistar rats has been investigated. Short-term plasticity was evaluated on the basis of changes in the slow-wave component of the focal potentials (FP) of the CA3 field of the hippocampus upon stimulation of the region of the dentate gyrus. The FP were recorded under nembutal anesthesia. In the groups of the hippocampus of adult and developing immunized rats, the greatest changes in short-term plasticity in the form of extreme intensification of the expressivity of the properties of paired facilitation and frequency potentiation were confined to the pyramidal layer. In the neocortex groups, the changes, as a rule, were less marked, and had the opposite sign; the main differences were found in the recording of the FP in the zone of the apical dendrites of the pyramidal neurons. It was noted that the focal activity of the young immunized animals is characterized by greater maturity as compared with the age norm. A conclusion is drawn regarding the different primary localization of the targets of the neuroimmune effect when antigens of different brain structures are used, namely hippocampus versus neocortex, and regarding the dependence of the physiological effect of neuroimmunization on the degree of maturity of the target structure.

Aging↗
PubMedDate not supplied

[Functional characteristics of the mature and developing brain following neuroimmunization: an analysis of the short-term plasticity of the rat hypothalamus].

In experiments on mature and developing (3-4 weeks old) rats the influence was shown of neuroimmunization with summate antigens of hippocampal or neocortical tissue cytosolic fraction on short-term plasticity of hippocampal CA3 field potentials under dentate gyrus zone stimulation. An increase of paired facilitation and frequency potentiation was revealed in pyramidal layer responses of hippocampal tissue immunized animals. In case of immunization with neocortical antigens the changes were less expressed, had mainly the opposite direction and took place in the apical dendrites zone. In young animals besides antigen spectrum depending effects of neuroimmunization an earlier manifestation (in comparison with age norm) of some focal activity definitive properties was described. The suggestions are made about different localization of hippocampal or neocortical tissue immunization "targets" with possible preferential damage of intrahippocampal systems when using this structure antigens, and also about dependence of physiological consequences on the extent of target structure ontogenetic maturity.

Animals↗