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Biomedical subjects

A P Cole

Publications and source records attributed to A P Cole.

At least 19 recordsLinked to original sources
PubMed1996

A trinuclear intermediate in the copper-mediated reduction of O2: four electrons from three coppers.

The reaction of metal complexes with dioxygen (O2) generally proceeds in 1:1, 21, or 41 (metal:O2) stoichiometry. A discrete, structurally characterized 31 product is presented. This mixed-valence trinuclear copper cluster, which contains copper in the highly oxidized trivalent oxidation state, exhibits O2 bond scission and intriguing structural, spectroscopic, and redox properties. The relevance of this synthetic complex to the reduction of O2 at the trinuclear active sites of multicopper oxidases is discussed.

Copper↗
PubMed1992

Euthanasia.

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Advance Directives↗
PubMed1992

Medical abortion.

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Abnormalities, Drug-Induced↗
PubMed1981

Human and animal togavirus antibodies in congenitally deformed infants.

The cord bloods of 30 congenitally malformed infants, born consecutively at the Worcester Royal Infirmary, were screened for serological evidence of infection with Border disease and bovine virus diarrhoea viruses as well as for the presence of rubella-, cytomegalovirus-, and measles-specific IgM. Despite Border disease and bovine virus diarrhoea being endemic among sheep and cattle in counties bordering Wales, none of the cord blood samples contained antibodies to Border disease or bovine virus diarrhoea viruses. No rubella-, measles-, or cytomegalovirus-specific IgM was detected. When the total immunoglobulins were estimated, 15 of the malformed infants and elevated levels, but in a control group of 35 infants born in the same unit, none showed significantly elevated immunoglobulin levels.

Antibodies, Viral↗
PubMed1977

Abnormalities of immunglobulins in infants with congenital heart disease.

Twenty-eight infants had their serum immunoglobulins estimated (by radial immunodiffusion) in early infancy. The IgG level was abnormal in twelve infants. Elevated levels of IgA were found in ten and IgM in fourteen. These variations, mostly obvious in the first ten days of life, were detected in the absence of clinical or immunological evidence of congenital rubella infection.

Heart Defects, Congenital↗
PubMed1976

The use of sodium valproate in a case of status epilepticus.

A child in status epilepticus, who did not respond to intravenous diazepam, was treated with sodium valproate by naso-gastric tube. Subsequent clinical and encephalographic improvement appeared to be related to the sodium valproate, and its value in cases of status epilepticus is discussed.

Child↗
PubMed1976

Idiopathic non-syphilitic paroxysmal cold haemoglobinuria in children.

Three examples of non-syphilitic paroxysmal cold haemoglobinuria (PCH) in children are described which occurred, within a period of 16 days, in association with a febrile illness. No definite viral aetiology or obvious epidemiological association could be established. A Donath-Landsteiner antibody of anti-P specificity was demonstrated in all three patients. The serological aspects of PCH are critically discussed.

Antibodies, Viral↗
PubMed1975

Continuous pethidine/diazepam infunsion during labour and its effects on the newborn.

This paper presents a study comparing the effects on the mother and baby of a continuous intravenous infusion of pethidine and diazepam and of intramuscular pethidine and promazine. It is concluded that the administration of intravenous pethidine and diazepam is safe in labour provided that diazepam has not been given during the previous week.

Anesthesia, Obstetrical↗