Biomedical subjects
A P Cole
Publications and source records attributed to A P Cole.
Medical abortion.
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Altered grounds for abortion?
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Human embryo research.
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Transient thrombocytopenia in a child on sodium valproate.
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Abnormalities of immunglobulins in infants with congenital heart disease.
Twenty-eight infants had their serum immunoglobulins estimated (by radial immunodiffusion) in early infancy. The IgG level was abnormal in twelve infants. Elevated levels of IgA were found in ten and IgM in fourteen. These variations, mostly obvious in the first ten days of life, were detected in the absence of clinical or immunological evidence of congenital rubella infection.
The use of sodium valproate in a case of status epilepticus.
A child in status epilepticus, who did not respond to intravenous diazepam, was treated with sodium valproate by naso-gastric tube. Subsequent clinical and encephalographic improvement appeared to be related to the sodium valproate, and its value in cases of status epilepticus is discussed.
Idiopathic non-syphilitic paroxysmal cold haemoglobinuria in children.
Three examples of non-syphilitic paroxysmal cold haemoglobinuria (PCH) in children are described which occurred, within a period of 16 days, in association with a febrile illness. No definite viral aetiology or obvious epidemiological association could be established. A Donath-Landsteiner antibody of anti-P specificity was demonstrated in all three patients. The serological aspects of PCH are critically discussed.
Letter: Tests for immigrant doctors.
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Continuous pethidine/diazepam infunsion during labour and its effects on the newborn.
This paper presents a study comparing the effects on the mother and baby of a continuous intravenous infusion of pethidine and diazepam and of intramuscular pethidine and promazine. It is concluded that the administration of intravenous pethidine and diazepam is safe in labour provided that diazepam has not been given during the previous week.
Diazepam and active metabolite in breast milk and their transfer to the neonate.
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Surgical correction of aortic valve stenosis with persistent ductus arterious and servere pulmonary hypertension.
This is a report of a case in which the unusual association of severe aortic valve stenosis with persistent ductus arteriosus complicated by severe pulmonary hypertension, was diagnosed and correction of the anatomical lesions carried out in one stage. Re-investigation after one year showed that the duct was closed, the pulmonary artery pressure was lower than before the operation and the gradient across the aortic valve reduced. A modern approach to treatment based on full cardiac assessment is stressed. Problems arising during the operation are discussed.
Management of persistent vegetative state.
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