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Biomedical subjects

A P Avtsyn

Publications and source records attributed to A P Avtsyn.

15 recordsLinked to original sources
PubMed1979

[NAG infection in Rana temporaria with suppressed normal intestinal microflora].

Frogs of the Rana temporaria species with disturbed biocenosis induced by combined effects of hypothermia (+4 degrees C) and tetracycline were used as an experimental model. The animals were inoculated orally with cultured NAD-vibrios and subjected to clinical, bacteriological, immunomorphological and electron microscopical examinations. The lymph-blood system was shown to be a possible pathway for generalization of the infection. Several causes of long-term persistence of the vibrios in Rana temporaria are discussed.

Animals↗
PubMed1976

[NAG infection of grass frog (Rana temporaria) tadpoles].

Rana temporaria tadpoles (2250) were contaminated with three types of NAG vibrio cultures. Clinical, bacteriological and morphological examinations showed the larvae to be suffering from an acute infection during the first 2 days after the contamination. Then the vibrios persisted in the tadpole organism for a long time and were excreted in the feces.

Animals↗
PubMed1976

[NAG-infection in grass frogs (Rana temporaria) subjected to hypothermia].

Rana temporaria kept under hypothermic conditions approaching anabiosis were inoculated with NAG-vibrios and examined clinically, bacteriologically, histologically, and electron microscopically. Oral inoculation of hypothermic frogs with NAG-vibrios resulted in 18 to 24 hours in the development of acute NAG-infection resembling the cholera-like syndrome, and characterized by general intoxication and local enteropathogenic effects. NAG-vibrios persisted in the frog gastrointestinal tract for a long time after the cessation of the acute period of the disease.

Acute Disease↗
PubMed1975

[Determination of choleragen activity in tadpoles].

A method of titration of the V. cholerae toxin obtained from the broth culture filtrates is presented. In difference from the earlier methods, the larvae of Rana temporaria were used as a test object. The tadpoles were placed in the vessels with water containing graded concentrations of the toxin. The titer of the toxin activity was evaluated by the percentage of dead tadpoles. The concentration causing the death of 50 per cent of the tadpoles in the course of the 24 hours was taken as a unit of toxin activity. The method is simple, easily reproducible and economical.

Animals↗
PubMed1975

[Choleragenic intoxication in hydrobionts].

Experiments were conducted on Rana temporaria in which cholerigenic intoxication was induced. Administration of high doses of choleragen caused in the epithelial cells of the small intestine of frogs structural-functional changes analogous to those observed in suckling rabbits used as a classic model for studying the mechanisms of cholerigenic intoxication.

Animals↗