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Biomedical subjects

A Ouchi

Publications and source records attributed to A Ouchi.

30 records · Page 2Linked to original sources
PubMed1988

Bone metabolism following gastric surgery: microdensitometry and single-photon absorptiometry.

The impairment of bone metabolism was investigated in patients who underwent gastrectomy or vagotomy with drainage two or more years ago. Serum biochemical analysis, microdensitometry of the 2nd metacarpal bone, and measurements of bone mineral content of the radius (measured 1/3 distally) using single-photon absorptiometry were performed at follow-up examination. Although serum levels of calcium, phosphorus and alkaline phosphatase were within normal range, alkaline phosphatase levels were slightly higher for the Billroth II group than for Billroth I. Twenty-eight of 50 gastrectomy cases (56%), and four of 10 vagotomy cases (40%) showed pathologically thin bone: microdensitometric (MD) scores were greater than 3. The Billroth II group showed a far higher frequency of greater MD scores than Billroth I. The MD scores showed significant positive relationship with the age at follow-up, but did not correlate well with the length of the postoperative period. Radial bone mineral content (BMC) was lower in patients with Billroth II anastomosis, or with total or proximal gastrectomy, than in those undergoing Billroth I. These results suggest that metabolic bone disorders following gastric surgery can be detected by MD score and BMC of appendicular bones. However, there was not sufficient resolution with these parameters to detect any bone changes in patients treated with active vitamin D3.

Adult↗
PubMed1986

[Clinicopathological study on minute- and small-gastric cancer--growing pattern in incipient phase of gastric cancer development and its clinical significance].

A clinicopathological study was performed on 13 cases of minute gastric cancer (14 lesions) with a diameter less than 5.0 mm and 33 cases of small gastric cancer (34 lesions) with a diameter between 5.1 mm and 10.0 mm. The incidence of flat lesions, multiple cancer and differentiated adenocarcinoma was more frequent in minute and small gastric cancer than in ordinary early gastric cancer with a diameter greater than 11 mm. The incidence of submucosal invasion in single cancer case (30.6%, 11/36) was significantly higher than that in multiple cancer case (8.3%, 1/12). The size of the smallest lesion invading the submucosal layer was 3.2 mm in diameter. Histological examination of the cancer lesions revealed that differentiated adenocarcinoma began to develop at the deeper mucosal layer, while undifferentiated adenocarcinoma did at the superficial mucosal layer. It was also demonstrated that the differentiated adenocarcinoma invaded the submucosal layer through the natural crevices of lamina muscularis mucosa. Pathological and mucohistochemical analysis of both the cancer cells and the surrounding mucosal tissue showed that intestinal metaplasia of the mucosa, especially mucohistochemically incomplete type metaplasia seemed to have close relation with the histogenesis of the differentiated adenocarcinoma.

Adenocarcinoma↗
PubMed1985

Histologic infiltrating pattern of gastric microcarcinoma by means of serial sections.

Two hundred eighty serial histologic sections, 5 micron thick, were made of a very small gastric carcinoma with submucosal invasion in order to assess the initial infiltrating pattern into the submucosa, as well as the growth therefrom. The small carcinoma infiltrated into the submucosa through four independent small channels, 0.02 to 0.05 mm2 in size, despite its small spread (3 mm in diameter) on the mucosal layer. Each small channel always was accompanied by the small blood vessels penetrating the lamina muscularis. The size of carcinoma in submucosa grew further to reach 3 to 10 times small infiltrating sites of lamina muscularis mucosa. The growth pattern of the carcinoma in the submucosa, therefore, seemed to be an "expanded balloon." Moreover, a small but distinct vascular invasion could be demonstrated within the balloon, suggesting a possible vascular metastasis.

Carcinoma↗
PubMed1985

[Clinicopathological study of a malignant lesion in the remnant stomach].

Thirty-six cases of malignant lesion in the remnant stomach were studied clinicopathologically. Ten had been surgically managed as benign lesions and eight were suspected of being metachronous multiple gastric cancer. The pathological characteristics of the malignant lesions and the operation interval (mostly more than 10 years) were similar in these two groups. Although malignant lesion in the remnant stomach is difficult to differentiate clearly when there is no sufficient histological evidence, the operation interval of more than 10 years can be one of the criteria for differential diagnosis.

Adult↗
PubMed1984

[Studies on the results of operations for carcinoma of the sigmoid colon].

Of 734 patients with colorectal cancer operated on during the past 21 years, 142 had carcinoma of the sigmoid colon. Curative resections were performed in 103 patients and non-curative resections in 22, the resection rate being 88.0%. Among 103 patients with curative resection, resection of the sigmoid colon was performed in 79, and their 5-year survival rate was 84.6%. Eight patients died within 5 years due to recurrence. Many of them had the constricting type macroscopically and Dukes C with positive lymph node metastasis. Therefore, in such cases, resection of the sigmoid colon with extended lymph node dissection or left hemicolectomy should be performed.

Adenocarcinoma↗
PubMed1983

[Early stomach cancer derived from heterotopic glands--a case report].

A 69-year-old man with early gastric cancer derived from heterotopic glands in the submucosal layer is reported. Macroscopically, two flat elevated lesions were found on the anterior and posterior walls of the stomach; histologic examination revealed submucosal cystic glands in each lesion. Carcinoma was proved only in the deeper part of the submucosal glands on the anterior wall; no obvious cancerous change was confirmed in the overlying mucosa and heterotopic glands in the posterior wall.

Aged↗
PubMed1983

[Clinico-pathological studies on multiple colorectal cancer].

Of 743 patients with colorectal cancer operated during the past 21 years, 52 with double cancer, excepting patients in whom the disease was associated with familial polyposis, were examined. A higher association of adenomas was noted in multiple carcinomas of the large intestine than in a single carcinoma. As most of the multiple carcinomas were located close to each portion, it is possible to resect the multiple tumors concomitantly during a single operative procedure. No recurrence or mortality was seen in patients with synchronous multiple carcinomas that coexisted with advanced and early cancers. However, all patients with two or more advanced cancers died a short time after the operation. In 66.7% of the cases the other organ involved in the double cancer was the stomach. When the cancers were in the early stage, long-term survival could be achieved even in the presence of synchronous double cancers. Despite the early detection of the primary cancer in metachronous double cancer, patients whose second cancer was in the advanced stage died shortly after the second operation.

Adult↗
PubMed1983

[Clinicopathological evaluation of patients surviving stomach cancer for 10 years following gastrectomy].

The clinicopathological findings on 232 patients with advanced gastric cancer who survived longer than 10 years after curative surgery were reviews and compared with those on 287 patients who died within 5 years of their operation. There were significantly more 10-year survivors in the group whose tumor size was less than 5 cm, where the center was not located in the cardia, in patients without lymph node involvement, less vessel invasion and higher lymphocyte infiltration around the stroma of the cancerous nests. No statistical differences were observed with regard to patient age, sex, Borrmann classification, histological types and invasive patterns between 10-year survivors and patients who died less than 50 years postoperatively.

Female↗
PubMed1976

Polyps and diverticulosis of large bowel in autopsy population of Akita prefecture, compared with Miyagi. High risk for colorectal cancer in Japan.

A necropsy study of polypoid lesions and diverticula of the large bowel in the Japanese prefectures of Akita and Miyagi indicated that adenomatous polyps were more numerous in Akita (30%) than Miyagi (18.3%). They also were larger and showed more severe atypia in Akita. The sigmoid colon and rectum showed the most severe atypia in both prefectures. Hyperplastic polyps and diverticula were very uncommon in both prefectures. These results are discussed in relation to the different levels of risk to colorectal carcinoma in these prefectures and in Japanese migrants to Hawaii.

Adolescent↗