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Biomedical subjects

A Osman

Publications and source records attributed to A Osman.

At least 109 records · Page 6Linked to original sources
PubMed1983

Mutagenic activity of heated potato/oil systems.

Mutagens detected with Salmonella typhimurium strain TA 98 in the presence of liver S9 mix were extracted from potato slices, but not pure potato starch, after frying in oil. No mutagenic activity was detected using strain TA 100, in the presence or absence of S9 mix with either fried potato slices or potato starch. Mutagenic activity was detected at frying temperatures of 140 degrees C and above. The mutagenic activity was limited to the outer portion of the fried potato slices and increased with frying time and temperature. Mutagenic activity ratios for extraction with both (NH4)2SO4/NH4OH and Na2SO4/NaOH were similar.

Food Contamination↗
PubMed1982

Lesion-produced telencephalic catecholamine imbalances and altered operant pecking rates in pigeons.

Pigeons with bilateral neurotoxic or electrolytic lesions within ventral mesencephalon, in nucleus tegmenti pedunculo pontinus (TP) (equivalent to substantia nigra) or area ventralis of Tsai (AVT), were found to have catecholamine (CA) depletion in the telencephalon, including the paleostriatum augmentatum (PA) and lobus parolfactorius (LPO), avian basal ganglia rich in CA. Joint telencephalic concentrations of dopamine (DA) and norepinephrine (NE) within individuals were found to vary with sustained fixed interval (FI) pecking rate increases or decreases following surgery. Low (below 75% of controls) DA/normal NE concentrations were found in individuals showing a marked reduction in their key pecking rates; low DA/low NE concentrations were found in individuals showing a marked increase in their pecking rates. The fit of these data with the NE-DA interaction hypothesis of Antelman and Caggiula [2] was acknowledged but the nature of that interaction remains to be clarified.

Animals↗
PubMed1980

Complex formation between copper(II) and thiobarbiturates.

Complex formation between copper(II) and selected thiobarbiturates was investigated via spectrophotometric procedures with absolute methanol as the solvent. The composition of the complexes proved to be 1:2 metal-ligand. The formation constants were computed using different procedures, and the results were reproducible. The electronic absorption spectra of the selected thiobarbiturates were studied. Spectrophotometric determination of the drugs was investigated.

Chemical Phenomena↗
PubMed1978

[Parameters of the cellular cyle during odontogenesis in mice].

Autoradiographic methods were used to analyze cell kinetics of mouse tooth germs during days 11, 14 and 16 of gestation. Cell cycle determination estimated from the labeled metaphases curves showed a lengthening of the cell cycle time during development, resulting from lengthening of G1 and S phases. These changes were also function of the histological localization of the analyzed cells.

Animals↗
PubMed1976

[Topographic distribution of mitosis in the lower incisor and 1st molar in the mouse embryo].

The analysis of serial frontal sections of lower mandibular arches of 14 to 18 days old mice embryos allowed the study of the pattern of mitosis in the incisor and the first molar. A very clear dissociation between the values of the mitotic index of the internal and external dental epithelia was observed. The high mitotic activity of the inner dental epithelium was considered as playing a very important role during the growth of these teeth.

Animals↗
PubMedDate not supplied

Post kala-azar ocular leishmaniasis.

The clinical features, diagnosis and treatment of 6 patients with post kala-azar ocular leishmaniasis are described. The eye lesions were associated with past or concomitant post kala-azar dermal leishmaniasis (PKDL). Four patients had post kala-azar leishmanial conjunctivitis and blepharitis. Using the polymerase chain reaction, the causative parasite was characterized as Leishmania donovani in 2 of these 4 patients. Two patients had post kala-azar anterior uveitis. The diagnosis of uveitis was based on the clinical manifestations, temporal relation to treated visceral leishmaniasis, the association with PKDL and positive anti-Leishmania serology. All patients were treated with systemic sodium stibogluconate. Patients with anterior uveitis were also treated with steroid and atropine eyedrops. The response to treatment was good. The importance of early diagnosis and treatment of ocular leishmaniasis is stressed.

Adolescent↗
PubMedDate not supplied

Heparin-bonded circuits improve clinical outcomes in emergency coronary artery bypass grafting.

Compared to patients undergoing elective or urgent coronary artery bypass grafting (CABG), those undergoing emergency CABG (EM-CABG) have a higher morbidity and mortality. The use of heparin-bonded circuits (HBC) has been shown to improve clinical outcomes in nonemergent CABG patients. It is not known, however, whether the improved hemostasis and attenuation of the inflammatory response to cardiopulmonary bypass, conferred by HBC, can overcome the high incidence of comorbid risk factors in (EM-CABG) patients and improve their outcomes. A retrospective analysis of 206 consecutive patients undergoing EM-CABG over 4 years (1993-1997) at one institution was performed. Eighty-one patients were treated with conventional non-heparin-bonded circuits (NHBC) with full anticoagulation protocol (FAP, activated clotting time [ACT] > 480 sec); 125 patients were treated with HBC and a lower anticoagulation protocol (LAP, ACT > 280 seconds). Outcomes and results were collected prospectively and are presented as mean +/- SD. Preoperative risk profiles were similar in both treatment groups. Postoperatively, compared with the NHBC group, patients treated with HBC/LAP required fewer homologous donor units (4.1 +/- 10.7 vs 8.2 +/- 13.6 units, p = 0.005), were less likely to require inotropic support (18.6% vs 38.3%, p = 0.005), and had a lower incidence of perioperative myocardial infarction (MI, 3.2% vs 12.3%, p = 0.04) and pulmonary complications (4.0% vs 12.3%, p = 0.04). The use of HBC/LAP resulted in a decreased incidence of postoperative complications (12.8% vs 28.4%, p = 0.01, odds ratio 0.37 with 95% confidence interval [CI] 0.18-0.76). This resulted in a shorter duration of ventilatory support (30.5 +/- 54.0 vs 72.8 +/- 16.7 hours, p = 0.009), ICU stay (38.2 +/- 36.5 vs 91.5 +/- 68.7 hours, p = 0.009), hospital stay (8.0 +/- 7.1 vs 11.0 +/- 8.9 days, p = 0.008), and therefore cost. In conclusion, the use of HBC/LAP in EM-CABG resulted in a reduction of homologous transfusion and postoperative complications associated with decreased hospital stays and cost.

Aged↗
PubMedDate not supplied

Risk factors for eye complications in patients with diabetes mellitus: development and progression.

A multicentre case-control study was conducted to identify and quantify risk factors that may influence the development and progression of diabetic retinopathy. A total of 200 diabetic patients with nonproliferative retinopathy were compared with 400 diabetic patients without any eye complications with regard to the development of diabetic retinopathy. They were also compared with 200 diabetic patients with major eye complications to study the progression of diabetic eye complications. Results showed that the progression of diabetic eye complications was preventable since all the variables significantly affecting the process of progression, except type of diabetes, were avoidable.

Analysis of Variance↗