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A Orsini

Publications and source records attributed to A Orsini.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Genetic approach to the study of heterogeneity of affective disorders.

In the present paper we compared the results of the application of segregation analysis, under two different single major locus (SML) transmission hypotheses, a dominant one with sex effect and a recessive one, to the families of 202 probands with major depression, recurrent and bipolar disorder. In the first analysis we considered only secondary cases with major affective disorders (bipolar disorders and major depression, recurrent), in the second one we included as affected phenotypes also relatives with atypical depression, dysthymic and cyclothymic disorders. Results indicated that considering spectrum disorders greatly modified familial segregation patterns.

Bipolar Disorder↗
PubMedDate not supplied

The value and present indications of staging laparotomy in Hodgkin's disease.

From December 1971 to December 1976 224 patients with Hodgkin's disease underwent diagnostic laparotomy and splenectomy under a multidisciplinary protocol of treatment. In 149/224 (66.5%) the clinical stage of the disease was confirmed, whereas in 75/224 (33.5%) it was modified after surgery. In 7.6% of the patients (17/224) there were postoperative complications. One patient died of myocardial infarction. The rate of complications in the last 100 cases was 5%. Preoperative patient selection, excluding those definitely in stage IV, is of relevance, and it can be done by iliac crest biopsy and laparoscopy. Although a better exploitation of some diagnostic procedures (lymphangiography, laparoscopy) and the expanding use of chemotherapy may reduce in the future the need for staging laparotomy and splenectomy, diagnostic laparotomy is still indicated for the selection and preparation of patients for radiation therapy in stages I, II and III.

Adolescent↗