SC-002 is a novel oral cephalosporin possessing a unique thiadiazolylethenyl moiety at the 3 position. In the present study, it was the most active against gram-positive bacteria among oral cephalosporins such as cefdinir (CFDN), cefpodoxime, cefditoren and cefaclor (CCL). It was equal to or 16 times more active than CFDN against standard and clinical strains. In particular, against clinical isolates of Morganella morganii and Haemophilus influenzae, SC-002 was 8-64 times more active than CFDN. The antibacterial activity of SC-002 against some beta-lactam-resistant strains was superior to that of CFDN. The in vivo antibacterial activity of SC-004, a pivaloyloxymethyl ester of SC-002, was 1.2-8 times more protective against systemic infections due to Streptococcus pneumoniae, Escherichia coli and Klebsiella pneumoniae than that of CFDN. The therapeutic effects of SC-004 on experimental respiratory tract infections caused by S. pneumoniae or H. influenzae were superior to those of CFDN and CCL. SC-004 showed higher and longer-lasting blood levels and higher urinary excretion in pharmacokinetics in mice.

Administration, Oral↗

PubMedDate not supplied

Atypical cilia of the human nasal mucosa.

Typical and atypical ultrastructural features of the cilia in the human nasal mucosa are reported in this paper. The specimens were taken from patients with the diagnosis of allergic rhinitis or chronic sinusitis. Most of the cilia showed a typical 9 + 2 arrangement of the axial filament complexes, but atypical axonemes such as 9 + 4, 8 + 2 and 10 + 2 patterns were found in six cilia of three patients. The supernumerary central fibrils were observed in one cilium only, whereas atypical patterns of the peripheral fibrils were found in five cilia. Cilia which contained a multiple axial filament complex, so-called compound clia, were also found in the mucosa of the chronic sinusitis cases. On the basis of their ultrastructural appearance, we classified these cilia into two groups, an "adhesive type" and a "bulging type." The former had a columnar shape of variable diameter, whereas the latter had a balloon-like form. The former contained closely packed multiple axial filament complexes whereas the latter possessed only sparse and irregularly oriented complexes. Electron-lucent lumina which were formed by the remnants of the ciliary membrane were frequently found in the former's transitional portion, but never in the latter.

Chronic Disease↗