[A story about the King of Denmark's horse, a mechanical ventilator and a righteous man of nations].
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Biomedical subjects
Publications and source records attributed to A Ohry.
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We present a patient with gradual development of camptocormia, three years before a non-Hodgkin's lymphoma was diagnosed. Lymphomas are known to produce neuromuscular symptoms through several indirect mechanisms. Recent studies regard camptocormia as a primary disease of the paravertebral muscles. To our knowledge this is the first report associating camptocormia with malignancy. The possibility of a paraneoplastic syndrome is discussed.
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Many studies have tried to explain why professionals experience difficulty when dealing with, and in treating efficiently situations connected with death. We studied levels of personal fear among physicians in general hospitals and addressed 2 questions: Does exposure to death on professional and personal levels, affect the level of the fear of personal death which physicians experience? Is there a relationship between personality variables, represented by the repression-sensitization dimension, and level of fear of personal death? A sample of 233 physicians from 22 general hospitals who specialized in oncology, internal medicine, surgery, psychiatry or pediatrics was studied. Each answered 4 questionnaires with regard to demographic information, fear of personal death, level of repression-sensitization and exposure to the death of relatives and significant others. There were no differences in level of fear of personal death of physicians according to specialization, but those who had been exposed to death on the personal level, feared less their own death. With respect to the personality variable, tendency to sensitization, it was found that those who were sensitized exhibited a higher level of the fear of their own death compared to those who were repressive. Of the various demographic variables examined (sex, level of religious observance, age, number of children, health, professional experience) it was found that those: with many years of professional experience, who were relatively older, who were nonobservant religiously and who were in good health, had lower levels of personal fear of death; gender was not a factor.
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Gynecomastia, an excessive development of the mammary glands in men, is a known phenomenon among patients with spinal cord disorder, yet in the last 50 years it has not been fully described in relation to spinal cord disorder. Over a period of 2 years, six patients with spinal cord disorder (4 secondary to a traumatic injury, 1 to decompression sickness, and 1 to transverse myelitis) manifested gynecomastia. The onset of gynecomastia occurred between 1 to 6 months after injury. These patients are presented along with a review of the possible causes for gynecomastia and a suggested workup routine. A clinical examination for the presence of gynecomastia should be performed for every patient with spinal cord disorder and a thorough endocrinological workup should follow to rule out malignancy and reassure the anxious patient undergoing a disruption of his body image.
Acetyl cholinesterase (AChE) antibodies were shown to be associated with myasthenia-like neuromuscular disease. However, it is not clear whether they cause the disease, or their presence is secondary to the disease or an unrelated epiphenomenon. Therefore, AChE antibodies were studied in the sera of 135 patients with neurologic, muscular and autoimmune diseases, using enzyme linked immunosorbent assay (ELISA), immunoblotting and enzyme inhibition assay. In 12 sera the AChE binding by ELISA was greater than 2 standard deviations (SDs) above the mean value of the 20 healthy controls. However, this increased binding was not disease-specific, had no clinical correlates and could not be demonstrated using Western blotting and AChE enzyme inhibition assay, suggesting that these antibodies are naturally occurring, pathogenically unimportant autoantibodies. The finding also supports a possible pathogenic role for the previously reported, high titer, high affinity, inhibitory AChE antibodies in the neuromuscular disease.
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Insulin action was assessed in spinal cord injured (SCI) male individuals (n = 5) and compared to controls (C) (n = 5). Mean (+/-SD) age and body weight were 27.0 +/- 5.1 and 24.5 +/- 1.6 years and 68.6 +/- 3.2 and 76.6 +/- 5.0 kg for SCI and C group, respectively. Subjects performed physical activities 2-3 times/week on a non-competitive basis. Using the euglycemic clamp, metabolic clearance rate of glucose (g-MCR) was measured twice, one week apart; at a basal state and then 1 h after aerobic exercise. Exercise consisted of 60 min arm-crank at 20-25 watt and 60 rpm. During the hyperinsulinemic clamp, insulin concentration was 76 +/- 14 and 67 +/- 9 microU.ml-1, in SCI and in controls, respectively. At baseline, g-MCR was comparable in SCI and C individuals (8.1 +/- 2.4 and 8.0 +/- 2.1 ml.kg-1.min-1, respectively). After exercise, g-MCR remained at 7.9 +/- 2.0 and 8.5 +/- 2.6 ml.kg-1.min-1 in SCI and C, respectively. In spite of muscle atrophy, peripheral sensitivity to insulin was not impaired in paraplegics. No increase in insulin response to the exercise stimulus was seen in any of the groups. It may thus be suggested that the daily level of activity and the physical training performed by paraplegics, are sufficient to eliminate a state of insulin resistance, which often develops in extremely sedentary populations.
In the absence of the recognition of the emotional sequelae following traumatic brain injury (TBI), many patients are deprived of adequate treatment. The purpose of the current study is to evaluate the prevalence of post-traumatic stress disorder (PTSD) and explore the clinical picture among TBI patients. Twenty four outpatients with diagnosed head injuries following various traumas filled out standardized questionnaires, assessing post-traumatic residuals. Thirty-three per cent of these patients met criteria for PTSD diagnosis. The clinical picture of PTSD following TBI is somewhat distinguished from those following other traumatic events. Issues concerning the specific nature of the syndrome following TBI, and the difficulties in differentiating between PTSD and postconcussive syndrome, are discussed.